There seems to be an emerging consensus among many philosophers of science that non-epistemic values ought to play a role in the process of scientific reasoning itself. Recently, a number of philosophers have focused on the role of values in scientific classification or taxonomy. Their claim is that a choice of ontology or taxonomic scheme can only be made, or should only be made, by appealing to non-epistemic or social values. In this paper, I take on this “argument from ontological (...) choice,” claiming that it equivocates on the notion of choice. An ontological choice can be understood either in terms of determining which taxonomic scheme is valid, or in terms of deciding which taxonomic scheme to deploy in a given context. I try to show that while the latter can be determined in part by social values, the former ought not to be so determined. (shrink)

In a recent article, David Ludwig proposed to reorient the debate on natural kinds away from inquiring into the naturalness of kinds and toward elucidating the materiality of kinds. This article responds to Ludwig’s critique of a recently proposed account of kinds and classification, the Grounded Functionality Account, against which Ludwig offsets his own account, and criticizes Ludwig’s proposal to shift focus from naturalness to materiality in the philosophy of kinds and classification.

In this article, we discuss epistemological limitations relating to the use of ethnoracial categories in biomedical research as devised by the Office of Management and Budget’s institutional guidelines. We argue that the obligation to use ethnoracial categories in genomics research should be abandoned. First, we outline how conceptual imprecision in the definition of ethnoracial categories can generate epistemic uncertainty in medical research and practice. Second, we focus on the use of ethnoracial categories in medical genetics, particularly genomics-based precision medicine, where (...) ethnoracial identity is understood as a proxy for medically relevant differences among individuals. Notably, extensive criticisms have been made already against the genetic interpretation of races, but, nonetheless, the concept of race remains a key element of contemporary genomics. This motivates us to explore possible reasons why such criticisms may have been ineffective in redirecting attention to other (non-race-based) ways of controlling for human variability. We contend that popular arguments against the idea that human races have a genetic basis, though convincing in many respects, are not sufficient to exclude the pragmatic use of race and ethnicity as proxies for genetic variability related to complex phenotypes. Finally, we provide two further arguments to support the idea that ethnoracial categories are unlikely to provide meaningful insights into medical genetics, which implies that even the interpretation of race as a useful tool to stratify disease risk is unwarranted. (shrink)

Abstract‘Obesity’ has, for decades, been a subject of intense scientific and public interest, and remains a key target for postgenomic science. I examine the emergence of determinism in research into ‘obesity’ in the postgenomic field of metabolomics. I argue that determinism appears in metabolomics research in two ways: firstly, fragmentation and narrow construal of the environment is evident in metabolomics studies on weight loss interventions, resulting in particular features of the environment (notably, dietary intake) having outsized influence while the wider (...) social environment is neglected. Secondly, studies aiming to characterize the metabolic signature of ‘obesity’ are guided by a commitment to a deterministic connection between ‘obesity’ and dysfunction, leading to a neglect or distortion of metabolic heterogeneity across individuals regardless of body size. (shrink)

The notion of natural kinds has been widely criticized in philosophy of science but also appears indispensable for philosophical engagement with classificatory practices. Rather than addressing this tension through a new definition of “natural kind”, this article suggests materiality as a substitute for naturalness in philosophical debates about scientific classification. It is argued that a theory of material kinds provides an alternative and more inclusive entry point for analyzing classificatory practices, which is specified through an account of “restricted malleability” of (...) materiality and further analyzed as (1) gradual, (2) multi-dimensional, (3) scalable, (4) interactive, and (5) purpose sensitive. (shrink)

The tradition of natural kinds has shaped philosophical debates about scientific classification but has come under growing criticism. Responding to this criticism, Reydon and Ereshefsky present their grounded functionality account as a strategy for updating and defending the tradition of natural kinds. This article argues that grounded functionality does indeed provide a fruitful philosophical approach to scientific classification but does not convince as a general theory of natural kinds. Instead, the strengths and limitations of Reydon and Ereshefsky’s account illustrate why (...) it is time to move beyond general definitions of “natural kind” and experiment with new philosophical frameworks. (shrink)