Emphatic claims of a “microbiome revolution” aside, the study of the gut microbiota and its role in organismal development and evolution is a central feature of so-called postgenomics; namely, a conceptual and/or practical turn in contemporary life sciences, which departs from genetic determinism and reductionism to explore holism, emergentism and complexity in biological knowledge-production. This paper analyses the making of postgenomic knowledge about developmental symbiosis in Drosophila melanogaster by a specific group of microbiome scientists. Drawing from both practical philosophy of (...) science and Science and Technology Studies, the paper documents epistemological questions of artefactuality and representativeness of model organisms as they emerge in the day-to-day labour producing and being produced by the “microbiome revolution." Specifically, the paper builds on all the written and editorial exchanges involved in the troubled publication of a research paper studying the symbiotic role of the microbiota in the flies’ development. These written materials permit us to delimit the network of justifications, evidence, standards of knowledge-production, trust in the tools and research designs that make up the conditions of possibility of a postgenomic fact. More than reframing the organism as a radically novel multiplicity of reactive genomes, we conclude, doing postgenomic research on the microbiota and symbiosis means producing a story that deviates from the scripts embedded into the sociotechnical experimental systems of post-Human Genome Project life sciences. (shrink)

Discourses on Responsible Innovation and Responsible Research and Innovation, in short RI, have revolved around but not elaborated on the notion of critique. In this article, generative critique is introduced to RI as a practice that sits in-between adversarial armchair critique and co-opted, uncritical service. How to position oneself and be positioned on this spectrum has puzzled humanities scholars and social scientists who engage in interdisciplinary collaborations with scientists, engineers, and other professionals. Recently, generative critique has been presented as a (...) solution to the puzzle in interdisciplinary collaborations on neuroscientific experiments. Generative critique seeks to create connections across disciplines that help remake seemingly stable objects in moments when taken-for-granted ways of seeing and approaching objects are unsettled. In order to translate generative critique from the neurosciences to RI, socio-technical integration research is proposed as a practice of generative critique in interdisciplinary RI collaborations. These collaborations aim to account for societal aspects in research and technology development. For this purpose, a variety of approaches have been developed, including STIR and video-reflexive ethnography. STIR and VRE resemble each other but diverge on affective, collaborative, and temporal dimensions. Their juxtaposition serves to develop suggestions for how STIR could be modified on these dimensions to better enact generative critique in interdisciplinary RI collaborations. In this way, the article contributes to ongoing discussions in RI and in the engaged programme in science and technology studies more broadly on the dynamics of positioning in collaborative work. (shrink)