In this paper, we argue that symbols are conventional vehicles whose chief function is denotation, while models are epistemic vehicles, and their chief function is to show what their targets are like in the relevant aspects. And we explain why this is incompatible with the deflationary view on scientific modeling. Although the same object may serve both functions, the two vehicles are conceptually distinct and most models employ both elements. With the clarification of this point we offer an alternative account (...) to the deflationary view – the Hybrid Account; and we defend our account in contrast with deflationism. (shrink)

Stanford’s argument against scientific realism focuses on theories, just as many earlier arguments from inconceivability have. However, there are possible arguments against scientific realism involving unconceived (or inconceivable) entities of different types: observations, models, predictions, explanations, methods, instruments, experiments, and values. This paper charts such arguments. In combination, they present the strongest challenge yet to scientific realism.

This paper contrasts and compares strategies of model-building in condensed matter physics and biology, with respect to their alleged unequal susceptibility to trade-offs between different theoretical desiderata. It challenges the view, often expressed in the philosophical literature on trade-offs in population biology, that the existence of systematic trade-offs is a feature that is specific to biological models, since unlike physics, biology studies evolved systems that exhibit considerable natural variability. By contrast, I argue that the development of ever more sophisticated experimental, (...) theoretical, and computational methods in physics is beginning to erode this contrast, since condensed matter physics is now in a position to measure, describe, model, and manipulate sample-specific features of individual systems – for example at the mesoscopic level – in a way that accounts for their contingency and heterogeneity. Model-building in certain areas of physics thus turns out to be more akin to modeling in biology than has been supposed and, indeed, has traditionally been the case. (shrink)

Scientific realism and anti-realism are most frequently discussed as global theses: theses that apply equally well across the board to all the various sciences. Against this status quo I defend the localist alternative, a methodological stance on scientific realism that approaches debates on realism at the level of individual sciences, rather than at science itself. After identifying the localist view, I provide a number of arguments in its defense, drawing on the diversity and disunity found in the sciences, as well (...) as problems with other approaches (such as basing realism debates on the aim of science). I also show how the view is already at work, explicitly or implicitly, in the work of several philosophers of science. After meeting the objections that localism collapses either into globalism or hyperlocalism, I conclude by sketching what sorts of impacts localism can have in the philosophy of science. (shrink)

If well-designed, the results of a Randomised Clinical Trial can justify a causal claim between treatment and effect in the study population; however, additional information might be needed to carry over this result to another population. RCTs have been criticized exactly on grounds of failing to provide this sort of information Evidence, inference and enquiry. Oxford University Press, New York, 2011), as well as to black-box important details regarding the mechanisms underpinning the causal law instantiated by the RCT result. On (...) the other side, so-called In Silico Clinical Trials face the same criticisms addressed against standard modelling and simulation techniques, and cannot be equated to experiments Philosophy of molecular medicine: foundational issues in research and practice, Routledge, New York, 2017; Parker in Synthese 169:483–496, 2009; Parke in Philos Sci 81:516–536, 2014; Diez Roux in Am J Epidemiol 181:100–102, 2015 and related discussions in Frigg and Reiss in Synthese 169:593–613, 2009; Winsberg in Synthese 169:575–592, 2009; Beisbart and Norton in Int Stud Philos Sci 26:403–422, 2012). We undertake a formal analysis of both methods in order to identify their distinct contribution to causal inference in the clinical setting. Britton et al.’s study :E2098–E2105, 2013) on the impact of ion current variability on cardiac electrophysiology is used for illustrative purposes. We deduce that, by predicting variability through interpolation, ISCTs aid with problems regarding extrapolation of RCTs results, and therefore in assessing their external validity. Furthermore, ISCTs can be said to encode “thick” causal knowledge —as opposed to “thin” difference-making information inferred from RCTs. Hence, ISCTs and RCTs cannot replace one another but rather, they are complementary in that the former provide information about the determinants of variability of causal effects, while the latter can, under certain conditions, establish causality in the first place. (shrink)

This paper explores the relation between scientific knowledge and common sense intuitions as a complement to Hoyningen-Huene’s account of systematicity. On one hand, Hoyningen-Huene embraces continuity between these in his characterization of scientific knowledge as an extension of everyday knowledge, distinguished by an increase in systematicity. On the other, he argues that scientific knowledge often comes to deviate from common sense as science develops. Specifically, he argues that a departure from common sense is a price we may have to pay (...) for increased systematicity. I argue that to clarify the relation between common sense and scientific reasoning, more attention to the cognitive aspects of learning and doing science is needed. As a step in this direction, I explore the potential for cross-fertilization between the discussions about conceptual change in science education and philosophy of science. Particularly, I examine debates on whether common sense intuitions facilitate or impede scientific reasoning. While contending that these debates can balance some of the assumptions made by Hoyningen-Huene, I suggest that a more contextualized version of systematicity theory could supplement cognitive analysis by clarifying important organizational aspects of science. (shrink)

This paper is a supplement to, and provides a proof of principle of, Kuhn vs. Popper on Criticism and Dogmatism in Science: A Resolution at the Group Level. It illustrates how calculations may be performed in order to determine how the balance between different functions in science—such as imaginative, critical, and dogmatic—should be struck, with respect to confirmation (or corroboration) functions and rules of scientific method.

This paper, which is based on recent empirical research at the University of Leeds, the University of Edinburgh, and the University of Bristol, presents two difficulties which arise when condensed matter physicists interact with molecular biologists: the former use models which appear to be too coarse-grained, approximate and/or idealized to serve a useful scientific purpose to the latter; and the latter have a rather narrower view of what counts as an experiment, particularly when it comes to computer simulations, than the (...) former. It argues that these findings are related; that computer simulations are considered to be undeserving of experimental status, by molecular biologists, precisely because of the idealizations and approximations that they involve. The complexity of biological systems is a key factor. The paper concludes by critically examining whether the new research programme of ‘systems biology’ offers a genuine alternative to the modelling strategies used by physicists. It argues that it does not. (shrink)

This article argues for an anti-deflationist view of scientific representation. Our discussion begins with an analysis of the recent Callender–Cohen deflationary view on scientific representation. We then argue that there are at least two radically different ways in which a thing can be represented: one is purely symbolic, and therefore conventional, and the other is epistemic. The failure to recognize that scientific models are epistemic vehicles rather than symbolic ones has led to the mistaken view that whatever distinguishes scientific models (...) from other representational vehicles must merely be a matter of pragmatics. It is then argued that even though epistemic vehicles also contain conventional elements, they do their job of demonstration in spite of such elements. (shrink)

This article develops an approach to modelling and models in science—the hybrid view—that is against model fictionalism of a recent stripe. It further argues that there is a version of fictionalism about models to which my approach is neutral and which makes sense only if one adopts a special sort of antirealism. Otherwise, my approach strongly suggests that one stay away from fictionalism and embrace realism directly.