Evidence-based medicine (EBM) makes use of explicit procedures for grading evidence for causal claims. Normally, these procedures categorise evidence of correlation produced by statistical trials as better evidence for a causal claim than evidence of mechanisms produced by other methods. We argue, in contrast, that evidence of mechanisms needs to be viewed as complementary to, rather than inferior to, evidence of correlation. In this paper we first set out the case for treating evidence of mechanisms alongside evidence of correlation in (...) explicit protocols for evaluating evidence. Next we provide case studies which exemplify the ways in which evidence of mechanisms complements evidence of correlation in practice. Finally, we put forward some general considerations as to how the two sorts of evidence can be more closely integrated by EBM. (shrink)

In this thesis, I give a metascientific account of causality in medicine. I begin with two historical cases of causal discovery. These are the discovery of the causation of Burkitt’s lymphoma by the Epstein-Barr virus, and of the various viral causes suggested for cervical cancer. These historical cases then support a philosophical discussion of causality in medicine. This begins with an introduction to the Russo- Williamson thesis (RWT), and discussion of a range of counter-arguments against it. Despite these, I argue (...) that the RWT is historically workable, given a small number of modifications. I then expand Russo and Williamson’s account. I first develop their suggestion that causal relationships in medicine require some kind of evidence of mechanism. I begin with a number of accounts of mechanisms and produce a range of consensus features of them. I then develop this consensus position by reference to the two historical case studies with an eye to their operational competence. In particular, I suggest that it is mechanistic models and their representations which we are concerned with in medicine, rather than the mechanism as it exists in the world. -/- I then employ these mechanistic models to give an account of the sorts of evidence used in formulating and evaluating causal claims. Again, I use the two human viral oncogenesis cases to give this account. I characterise and distinguish evidence of mechanism from evidence of difference-making, and relate this to mechanistic models. I then suggest the relationship between types of evidence presents us with a means of tackling the reference-class problem. This sets the scene for the final chapter. Here, I suggest the manner in which these two different classes of evidence become integrated is also reflected in the way that developing research programmes change as their associated causal claims develop. (shrink)

The article begins by describing two longstanding problems associated with direct inference. One problem concerns the role of uninformative frequency statements in inferring probabilities by direct inference. A second problem concerns the role of frequency statements with gerrymandered reference classes. I show that past approaches to the problem associated with uninformative frequency statements yield the wrong conclusions in some cases. I propose a modification of Kyburg’s approach to the problem that yields the right conclusions. Past theories of direct inference have (...) postponed treatment of the problem associated with gerrymandered reference classes by appealing to an unexplicated notion of projectability . I address the lacuna in past theories by introducing criteria for being a relevant statistic . The prescription that only relevant statistics play a role in direct inference corresponds to the sort of projectability constraints envisioned by past theories. (shrink)

This article explores the connection between objective chance and the randomness of a sequence of outcomes. Discussion is focussed around the claim that something happens by chance iff it is random. This claim is subject to many objections. Attempts to save it by providing alternative theories of chance and randomness, involving indeterminism, unpredictability, and reductionism about chance, are canvassed. The article is largely expository, with particular attention being paid to the details of algorithmic randomness, a topic relatively unfamiliar to philosophers.

One of Julian Barbour’s main aims is to solve the problem of time that appears in quantum geometrodynamics (QG). QG involves the application of canonical quantization procedure to the Hamiltonian formulation of General Relativity. The problem of time arises because the quantization of the Hamiltonian constraint results in an equation that has no explicit time parameter. Thus, it appears that the resulting equation, as apparently timeless, cannot describe evolution of quantum states. Barbour attempts to resolve the problem by allegedly eliminating (...) time from his interpretation of QG. In order to evaluate the efficacy of his solution, it is necessary to ascertain in what sense time has been eliminated from his theory. I proceed to do so by developing a form of conceptual analysis that is applicable to the concept of time in physical theories and applying this analysis to Barbour’s account. (shrink)

The anti-causal prophecies of last century have been disproved. Causality is neither a ‘relic of a bygone’ nor ‘another fetish of modern science’; it still occupies a large part of the current debate in philosophy and the sciences. This investigation into causal modelling presents the rationale of causality, i.e. the notion that guides causal reasoning in causal modelling. It is argued that causal models are regimented by a rationale of variation, nor of regularity neither invariance, thus breaking down the dominant (...) Human paradigm. The notion of variation is shown to be embedded in the scheme of reasoning behind various causal models: e.g. Rubin’s model, contingency tables, and multilevel analysis. It is also shown to be latent – yet fundamental – in many philosophical accounts. Moreover, it has significant consequences for methodological issues: the warranty of the causal interpretation of causal models, the levels of causation, the characterisation of mechanisms, and the interpretation of probability. This book offers a novel philosophical and methodological approach to causal reasoning in causal modelling and provides the reader with the tools to be up to date about various issues causality rises in social science. (shrink)

Generics and frequency statements are puzzling phenomena: they are lawlike, yet contingent. They may be true even in the absence of any supporting instances, and extending the size of their domain does not change their truth conditions. Generics and frequency statements are parametric on time, but not on possible worlds; they cannot be applied to temporary generalizations, and yet are contingent. These constructions require a regular distribution of events along the time axis. Truth judgments of generics vary considerably across speakers, (...) whereas truth judgments of frequency statements are much more uniform. A generic may be false even if the vast majority of individuals in its domain satisfy the predicated property, whereas a frequency statement using, e.g., usually would be true. This paper argues that all these seemingly unrelated puzzles have a single underlying cause: generics and frequency statements express probability judgments, and these, in turn, are interpreted as statements of hypothetical relative frequency. (shrink)

Carl G. Hempel's doctrine of essential epistemic relativization of inductive-statistical explanation seems to entail the unintelligibility of the notion of objective homogeneity of reference classes. This discussion note explores the question of whether, as a consequence, essential epistemic relativization also entails the unintelligibility of the doctrine of indeterminism.

My purpose here is to elaborate the reasons I maintain that Salmon has not been completely successful in reporting the history of work on explanation. The most important limitation of his account is that it does not emphasize the critical necessity to embrace a suitable conception of probability in the development of the theory of probabilistic explanation.

Philip Kitcher and Wesley C. Salmon have edited an important anthology of new papers on scientific explanation, a central problem—possibly the central problem—in the theory of science. Their collection begins with a comprehensive essay by Salmon that attempts to trace the development of work on this issue from Hempel and Oppenheim to the present. The University of Minnesota Press has published this article as a separate volume, which it is promoting as “a definitive introduction” to this area of inquiry. Apart (...) from its preface and indices, the Salmon volume is identical with the original essay. (shrink)

A general form is proposed for epistemological theories, the relevant factors being: the family of epistemic judgments, the epistemic state, the epistemic commitment, and the family of possible epistemic inputs. First a simple theory is examined in which the states are probability functions, and the subject of probability kinematics introduced by Richard Jeffrey is explored. Then a second theory is examined in which the state has as constituents a body of information and a recipe that determines the accepted epistemic judgments (...) on the basis of this corpus. Through an examination of several approaches to the statistical syllogism, a relation is again established with Jeffrey's generalized conditionalization. (shrink)