This article is concerned to formulate some open problems in the philosophy of space and time that require methods characteristic of mathematical traditions in the foundations of geometry for their solution. In formulating the problems an effort has been made to fuse the separate traditions of the foundations of physics on the one hand and the foundations of geometry on the other. The first part of the paper deals with two classical problems in the geometry of space, that of giving (...) operationalism an exact foundation in the case of the measurement of spatial relations, and that of providing an adequate theory of approximation and error in a geometrical setting. The second part is concerned with physical space and space-time and deals mainly with topics concerning the axiomatic theory of bodies, the operational foundations of special relativity and the conceptual foundations of elementary physics. (shrink)