This paper discusses the constitution relation within the framework of the mechanistic approach to neurobiological explanation. It develops a regularity theory of constitution as an alternative to the manipulationist theory of constitution advocated by some of the proponents of the mechanistic approach. After the main problems of the manipulationist account of constitution have been reviewed, the regularity account is developed based on the notion of a minimal type relevance theory. A minimal type relevance theory expresses a minimally necessary condition of (...) a given type that consists of a disjunction of minimally sufficient conditions of that type. Afterwards, the attained definition is successfully applied in an analysis of the logical structure of the explanation of spatial learning and memory in rats as a paradigm neurobiological explanation. The overall result is a more robust and more precise version of the mechanistic approach to neurobiological explanations. (shrink)

In what sense do the sciences explain? Or do they merely describe what is going on without answering why-questions at all. But cannot description at an appropriate ‘level’ provide all that we can reasonably ask of an explanation? Well, what do we mean by explanation anyway? What, if anything, gets left out when we provide a so-called scientific explanation? Are there limits of explanation in general, and scientific explanation, in particular? What are the criteria for a good explanation? Is it (...) possible to satisfy all the desiderata simultaneously? If not, which should we regard as paramount? What is the connection between explanation and prediction? What exactly is it that statistical explanations explain? These are some of the questions that have generated a very extensive literature in the philosophy of science. In attempting to answer them, definite views will have to be taken on related matters, such as physical laws, causality, reduction, and questions of evidence and confirmation, of theory and observation, realism versus antirealism, and the objectivity and rationality of science. I will state my own views on these matters, in the course of this essay. To argue for everything in detail and to do justice to all the alternative views, would fill a book, perhaps several books. I want to lead up fairly quickly to modern physics, and review the explanatory situation there in rather more detail. (shrink)

Humeans take reality to be devoid of ‘necessary connections’: things just happen. Laws of nature are to be understood in terms of what ‘just happens’, not vice versa. Here the Humean needs some conception of what it is that ‘just happens’ – a conception of the Humean mosaic. Lewis’s Humeanism incorporates such a conception in the form of a Lewis-style metaphysics of objects, properties, and modality. Newer versions of Humeanism about laws of nature, such as the Better Best Systems approach, (...) typically reject such a Lewisian metaphysics, but it remains unclear what they can offer in its place. By exploring different candidate conceptions, this paper sheds light on the limits of Humeanism about laws of nature: not all conceptions of the Humean mosaic form a suitable basis for a Humean theory of laws. In fact, only a metaphysics roughly in line with Lewis’s will do. The paper ends with a tentative generalization of this result, thus pointing to the ‘limit’ of Humeanism in general: taking the Humean way of thinking to its limit results in a rejection of the whole idea of such a mosaic – and hence of Humean mosaic-based accounts of anything. (shrink)