Philosophers of science diverge on the question what drives the growth of scientific knowledge. Most of the twentieth century was dominated by the notion that theories propel that growth whereas experiments play secondary roles of operating within the theoretical framework or testing theoretical predictions. New experimentalism, a school of thought pioneered by Ian Hacking in the early 1980s, challenged this view by arguing that theory-free exploratory experimentation may in many cases effectively probe nature and potentially spawn higher evidence-based theories. Because (...) theories are often powerless to envisage workings of complex biological systems, theory-independent experimentation is common in the life sciences. Some such experiments are triggered by compelling observation, others are prompted by innovative techniques or instruments, whereas different investigations query big data to identify regularities and underlying organizing principles. A distinct fourth type of experiments is motivated by a major question. Here I describe two question-guided experimental discoveries in biochemistry: the cyclic adenosine monophosphate mediator of hormone action and the ubiquitin-mediated system of protein degradation. Lacking underlying theories, antecedent data bases, or new techniques, the sole guides of the two discoveries were respective substantial questions. Both research projects were similarly instigated by theory-free exploratory experimentation and continued in alternating phases of results-based interim working hypotheses, their examination by experiment, provisional hypotheses again, and so on. These two cases designate theory-free, question-guided, stepwise biochemical investigations as a distinct subtype of the new experimentalism mode of scientific enquiry. (shrink)

The aim of this work is to elucidate John F. W. Herschel’s distinctive contribution to nineteenth-century British inductivism by exploring his understanding of experimental methods. Drawing on both his explicit discussion of experiment in his Preliminary Discourse on Natural Philosophy and his published account of experiments he conducted in the domain of electromagnetism, I argue that the most basic principle underlying Herschel’s epistemology of experiment is that experiment enables a particular kind of lower-level experimental understanding of phenomena. Experimental practices provide (...) knowledge of a particular phenomenon as a genuine effect produced under precise material conditions whose connections with other phenomena can be traced by variations in experimental parameters. The orienting concern of experimental inquiry seems to be the production of a secure understanding of phenomena even if it has no direct theoretical significance. Insofar as one can generate this lower-level understanding, it can function both as a fertile source for explanatory principles about phenomena and as a body of evidence against which one can test the adequacy of an explanatory hypothesis. This project provides evidence of Herschel’s inductivism not merely as a philosophical approach to understanding the sciences but as a methodological commitment in scientific practice. (shrink)

In this essay, my aim is twofold: to clarify how the late Mill conceived of the certainty of inductive generalizations and to offer a systematic clarification of the limited domain of application of the Mill’s Canons of Induction. I shall argue that Mill’s views on the certainty of knowledge changed overtime and that this change was accompanied by a new view on the certainty of the inductive results yielded by the Canons of Induction. The key message of the later editions (...) of The System of Logic as conceived by the late Mill was no longer that by the Canons of Induction we can establish scientific certainty and true causes, but rather that the Canons are useful in establishing causal laws in a provisional way. (shrink)

This paper takes as its point of departure two striking incongruities between scientiªc practice and trends in modern history and philosophy of science. (1) Many modern historians of science are so preoccupied with local scientiªc practices that they fail to recognize important non-local elements. (2) Many modern philosophers of science make a sharp distinction between explanation and evidence, whereas in scientiªc practice explanatory power is routinely used as evidence for scientiªc claims. I draw attention to one speciªc way in..

In this paper I demonstrate that, contrary to the standard interpretations, William Whewell's view of scientific method is neither that of the hypothetico-deductivist nor that of the retroductivist. Rather, he offers a unique inductive methodology, which he calls "discoverers' induction." After explicating this methodology, I show that Kepler's discovery of his first law of planetary motion conforms to it, as Whewell claims it does. In explaining Whewell's famous phrase about "happy guesses" in science, I suggest that Whewell intended a distinction (...) between "inductions," which can be empirically verified, and "mere hypotheses"--or guesses--which cannot. Finally, I argue that Whewell's discoverers' induction is a view worthy of our attention today, because it avoids a number of problems faced by prominent alternative methodologies. (shrink)

(2000). ROBERT LESLIE ELLIS AND JOHN STUART MILL ON THE ONE AND THE MANY OF FREQUENTISM. British Journal for the History of Philosophy: Vol. 8, No. 2, pp. 251-274.

1. Overview and organizing themes 2. Historical Review: Aristotle to Mill 3. Logic of method and critical responses 3.1 Logical constructionism and Operationalism 3.2. H-D as a logic of confirmation 3.3. Popper and falsificationism 3.4 Meta-methodology and the end of method 4. Statistical methods for hypothesis testing 5. Method in Practice 5.1 Creative and exploratory practices 5.2 Computer methods and the ‘third way’ of doing science 6. Discourse on scientific method 6.1 “The scientific method” in science education and as seen (...) by scientists 6.2 Privileged methods and ‘gold standards’ 6.3 Scientific method in the court room 6.4 Deviating practices 7. Conclusion Bibliography Academic Tools Other Internet Resources Related Entries . (shrink)

John Herschel's discussion of hypotheses in the Preliminary Discourse on Natural Philosophy has generated questions concerning his commitment to the principle that hypothetical speculation is legitimate only if warranted by inductive evidence. While Herschel explicitly articulates an inductivist philosophy of science, he also asserts that “it matters little how {a hypothesis or theory} has been originally framed” when it can withstand extensive testing and empirical scrutiny. This evidence has convinced some that Herschel endorses an early form of hypothetico-deductivism. I aim (...) to clarify this interpretive puzzle and adduce evidence in support of the inductivist interpretation of Herschel's philosophy of science by examining his published account of a series of experiments in the domain of electromagnetism. (shrink)

Primarily between 1833 and 1840, William Whewell attempted to accomplish what natural philosophers and scientists since at least Galileo had failed to do: to provide a systematic and broad-ranged study of the tides and to attempt to establish a general scientific theory of tidal phenomena. I document the close interaction between Whewell’s philosophy of science and his scientific practice as a tidologist. I claim that the intertwinement between Whewell’s methodology and his tidology is more fundamental than has hitherto been documented.Keywords: (...) William Whewell; Tidology; History of HPS; Scientific methodology; Whewell papers. (shrink)

In this paper, I examine William Whewell’s (1794–1866) ‘Discoverer’s Induction’, and argue that it 21 supplies a strikingly accurate characterization of the logic behind many statistical methods, exploratory 22 data analysis (EDA) in particular. Such methods are additionally well-suited as a point of evaluation of 23 Whewell’s philosophy since the central techniques of EDA were not invented until after Whewell’s death, 24 and so couldn’t have influenced his views. The fact that the quantitative details of some very general 25 methods (...) designed to suggest hypotheses would so closely resemble Whewell’s views of how theories 26 are formed is, I suggest, a strongly positive comment on these views. (shrink)