Often our reason for doing something is an "instrumental reason": that doing that is a means to doing something else that we have reason to do. What principles govern this "instrumental transmission" of reasons from ends to means? Negatively, I argue against principles often invoked in the literature, which focus on necessary or sufficient means. Positively, I propose a principle, "General Transmission," which answers to two intuitive desiderata: that reason transmits to means that are "probabilizing" and "nonsuperfluous" with respect to (...) the relevant end. I then apply General Transmission to the debate over "detachment": whether "wide-scope" reason for a material conditional or disjunction implies "narrow-scope" reason for the consequent or disjuncts. (shrink)

Measuring the effectiveness of medical interventions faces three epistemological challenges: the choice of good measuring instruments, the use of appropriate analytic measures, and the use of a reliable method of extrapolating measures from an experimental context to a more general context. In practice each of these challenges contributes to overestimating the effectiveness of medical interventions. These challenges suggest the need for corrective normative principles. The instruments employed in clinical research should measure patient-relevant and disease-specific parameters, and should not be sensitive (...) to parameters that are only indirectly relevant. Effectiveness always should be measured and reported in absolute terms (using measures such as 'absolute risk reduction'), and only sometimes should effectiveness also be measured and reported in relative terms (using measures such as 'relative risk reduction')-employment of relative measures promotes an informal fallacy akin to the base-rate fallacy, which can be exploited to exaggerate claims of effectiveness. Finally, extrapolating from research settings to clinical settings should more rigorously take into account possible ways in which the intervention in question can fail to be effective in a target population. (shrink)

Many believe that normative reasons for action are necessarily connected with the promotion of certain states of affairs: on Humean views, for example, there is a reason for you to do something if and only if it would promote the object of one of your desires. But although promotion is widely invoked in discussions of reasons, its nature is a matter of controversy. I propose a simple account: to promote a state of affairs is to make it more likely to (...) obtain than it previously was. I argue that this view has been unfairly neglected, that it avoids serious problems faced by many other views, and that it is a contender for the correct theory of promotion. (shrink)