This article considers the prospects of inference to the best explanation as a method of confirming causal claims vis-à-vis the medical evidence of mechanisms. I show that IBE is actually descriptive of how scientists reason when choosing among hypotheses, that it is amenable to the balance/weight distinction, a pivotal pair of concepts in the philosophy of evidence, and that it can do justice to interesting features of the interplay between mechanistic and population level assessments.

Relationships of counterfactual dependence have played a major role in recent debates of explanation and understanding in the philosophy of science. Usually, counterfactual dependencies have been viewed as the explanantia of explanation, i.e., the things providing explanation and understanding. Sometimes, however, counterfactual dependencies are themselves the targets of explanations in science. These kinds of explanations are the focus of this paper. I argue that “micro-level model explanations” explain the particular form of the empirical regularity underlying a counterfactual dependency by representing (...) it as a physical necessity on the basis of postulated microscopic entities. By doing so, micro-level models rule out possible forms the regularity could have taken. Micro-model explanations, in other words, constrain empirical regularities and their associated counterfactual dependencies. I introduce and illustrate micro-level model explanations in detail, contrast them to other accounts of explanation, and consider potential problems. (shrink)

One of the popular realist responses to the pessimistic meta-induction is the ‘selective’ move, where a realist only commits to the ‘working posits’ of a successful theory, and withholds commitment to ‘idle posits’. Antirealists often criticise selective realists for not being able to articulate exactly what is meant by ‘working’ and/or not being able to identify the working posits except in hindsight. This paper aims to establish two results: sometimes a proposition is, in an important sense, ‘doing work’, and yet (...) does not warrant realist commitment, and the realist will be able to respond to PMI-style historical challenges if she can merely show that certain selected posits do not require realist commitment. These two results act to significantly adjust the dialectic vis-à-vis PMI-style challenges to selective realism. (shrink)