How can a reflective scientist put forward an explanation using a model when they are aware that many of the assumptions used to specify that model are false? This paper addresses this challenge by making two substantial assumptions about explanatory practice. First, many of the propositions deployed in the course of explaining have a non-representational function. In particular, a proposition that a scientist uses and also believes to be false, i.e. an “idealization”, typically has some non-representational function in the practice, (...) such as the interpretation of some model or the specification of the target of the explanation. Second, when an agent puts forward an explanation using a model, they usually aim to remain agnostic about various features of the phenomenon being explained. In this sense, explanations are intended to be autonomous from many of the more fundamental features of such systems. I support these two assumptions by showing how they allow one to address a number of recent concerns raised by Bokulich, Potochnik and Rice. In addition, these assumptions lead to a defense of the view that explanations are wholly true that improves on the accounts developed by Craver, Mäki and Strevens. (shrink)

I argue that difference-making should be a crucial element for evaluating the quality of evidence for mechanisms, especially with respect to the robustness of mechanisms, and that it should take central stage when it comes to the general role played by mechanisms in establishing causal claims in medicine. The difference- making of mechanisms should provide additional compelling reasons to accept the gist of Russo-Williamson thesis and include mechanisms in the protocols for Evidence- Based Medicine (EBM), as the EBM+ research group (...) has been advocating. (shrink)

This article considers the prospects of inference to the best explanation as a method of confirming causal claims vis-à-vis the medical evidence of mechanisms. I show that IBE is actually descriptive of how scientists reason when choosing among hypotheses, that it is amenable to the balance/weight distinction, a pivotal pair of concepts in the philosophy of evidence, and that it can do justice to interesting features of the interplay between mechanistic and population level assessments.

Proportionality—the idea that causes are neither too general nor too specific for their effects—seems to recommend implausibly disjunctive causes (McGrath, 1998 ; Shapiro & Sober, 2012 ; Franklin-Hall, 2016 ). I argue that this problem should be avoided by appeal to the notion of cohesion. I propose an account of cohesion in terms of the similarity structure of property-spaces, argue that it is not objectionably mysterious, and that alternative approaches—based on naturalness, interventionism, and contrastivism—are inadequate without appeal to it. In (...) an appendix, I show how my proposal can be perspicuously formalized by adapting structural equation models. (shrink)

One of the popular realist responses to the pessimistic meta-induction is the ‘selective’ move, where a realist only commits to the ‘working posits’ of a successful theory, and withholds commitment to ‘idle posits’. Antirealists often criticise selective realists for not being able to articulate exactly what is meant by ‘working’ and/or not being able to identify the working posits except in hindsight. This paper aims to establish two results: sometimes a proposition is, in an important sense, ‘doing work’, and yet (...) does not warrant realist commitment, and the realist will be able to respond to PMI-style historical challenges if she can merely show that certain selected posits do not require realist commitment. These two results act to significantly adjust the dialectic vis-à-vis PMI-style challenges to selective realism. (shrink)