An account of scientific representation in terms of partial structures and partial morphisms is further developed. It is argued that the account addresses a variety of difficulties and challenges that have recently been raised against such formal accounts of representation. This allows some useful parallels between representation in science and art to be drawn, particularly with regard to apparently inconsistent representations. These parallels suggest that a unitary account of scientific and artistic representation is possible, and our article can be viewed (...) as laying the groundwork for such an account—although, as we shall acknowledge, significant differences exist between these two forms of representation. (shrink)

A biochemical pathway is a sequence of chemical reactions in a biological organism. Such pathways specify mechanisms that explain how cells carry out their major functions by means of molecules and reactions that produce regular changes. Many diseases can be explained by defects in pathways, and new treatments often involve finding drugs that correct those defects. This paper presents explanation schemas and treatment strategies that characterize how thinking about pathways contributes to biomedical discovery. It discusses the significance of pathways for (...) understanding the nature of diseases, explanations, and theories. (shrink)

We present a precise form of structural realism, called group structural realism , which identifies ‘structure’ in quantum theory with symmetry groups. However, working out the details of this view actually illuminates a major problem for structural realism; namely, a structure can itself have structure. This article argues that, once a precise characterization of structure is given, the ‘metaphysical hierarchy’ on which group structural realism rests is overly extravagant and ultimately unmotivated.

In this paper, a modest version of the Semantic View is motivated as both tenable and potentially fruitful for philosophy of science. An analysis is proposed in which the Semantic View is characterized by three main claims. For each of these claims, a distinction is made between stronger and more modest interpretations. It is argued that the criticisms recently leveled against the Semantic View hold only under the stronger interpretations of these claims. However, if one only commits to the modest (...) interpretation for all the claims, then the view obtained, the Modest Semantic View, is tenable and fruitful for the philosophy of science. (shrink)

_Figure 1. Dendrites and cell bodies of schematic neurons connected by dendritic-dendritic gap junctions form a laterally connected input_ _layer (“dendritic web”) within a neurocomputational architecture. Dendritic web dynamics are temporally coupled to gamma synchrony_ _EEG, and correspond with integration phases of “integrate and fire” cycles. Axonal firings provide input to, and output from, integration_ _phases (only one input, and three output axons are shown). Cell bodies/soma contain nuclei shown as black circles; microtubule networks_ _pervade the cytoplasm. According to the (...) Orch OR theory, gamma EEG-synchronized integration phases include quantum computations in_ _microtubule networks which culminate with conscious moments. Insert closeup shows a gap junction through which microtubule quantum_ _states entangle among different neurons, enabling macroscopic quantum states in dendritic webs extending throughout cortex and other_ _brain regions._. (shrink)

I review a widely accepted argument to the conclusion that the contents of our beliefs, desires and other mental states cannot be causally efficacious in a classical computational model of the mind. I reply that this argument rests essentially on an assumption about the nature of neural structure that we have no good scientific reason to accept. I conclude that computationalism is compatible with wide semantic causal efficacy, and suggest how the computational model might be modified to accommodate this possibility.

I propose a new approach to the constitutive problem of psychology ‘what is mind?’ The first section introduces modifications of the received scope, methodology, and evaluation criteria of unified theories of cognition in accordance with the requirements of evolutionary compatibility and of a mature science. The second section outlines the proposed theory. Its first part provides empirically verifiable conditions delineating the class of meaningful neural formations and modifies accordingly the traditional conceptions of meaning, concept and thinking. This analysis is part (...) of a theory of communication in terms of inter-level systems of primitives that proposes the communication-understanding principle as a psychological invariance. It unifies a substantial amount of research by systematizing the notions of meaning, thinking, concept, belief, communication, and understanding and leads to a minimum vocabulary for this core system of mental phenomena. Its second part argues that written human language is the key characteristic of the artificially natural human mind. Overall, the theory both supports Darwin’s continuity hypothesis and proposes that the mental gap is within our own species. (shrink)

The late 19th-century Ignorabimus controversy over the limits of scientific knowledge has often been characterized as proclaiming the end of intellectual progress, and by implication, as plunging Germany into a crisis of pessimism from which Liberalism never recovered. My research supports the opposite interpretation. The initiator of the Ignorabimus controversy, Emil du Bois-Reymond, was a physiologist who worked his whole life against the forces of obscurantism, whether they came from the Catholic and Conservative Right or the scientistic and millenarian Left. (...) Du Bois-Reymond’s doubt that scientists would ever elucidate consciousness must therefore be seen as an endorsement, and not a rejection, of his faith in reason. (shrink)

Tradition compels me to write dissertation acknowledgements that are long, effusive, and unprofessional. Fortunately for me, I heartily endorse that tradition.