On what grounds could life be made worth living given its abundant suffering? Friedrich Nietzsche was one among many who attempted to answer this question. This book attempts to disentangle Nietzsche's various critiques of pessimism, elucidating how familiar Nietzschean themes ought to be assessed against this philosophical backdrop.

Ioannidis [Why most published research findings are false. PLoS Med 2: e124 ] identifies six factors that contribute to explaining why most of the current published research findings are more likely to be false than true, and argues that for many current scientific fields, claimed research findings may often be simply accurate measures of the prevailing bias. In this article, we argue that three “hot” areas in current biological research, viz., agent-based modeling, evolutionary developmental biology, and systems biology, are especially (...) prone to the flaws. (shrink)