In this article, we discuss epistemological limitations relating to the use of ethnoracial categories in biomedical research as devised by the Office of Management and Budget’s institutional guidelines. We argue that the obligation to use ethnoracial categories in genomics research should be abandoned. First, we outline how conceptual imprecision in the definition of ethnoracial categories can generate epistemic uncertainty in medical research and practice. Second, we focus on the use of ethnoracial categories in medical genetics, particularly genomics-based precision medicine, where (...) ethnoracial identity is understood as a proxy for medically relevant differences among individuals. Notably, extensive criticisms have been made already against the genetic interpretation of races, but, nonetheless, the concept of race remains a key element of contemporary genomics. This motivates us to explore possible reasons why such criticisms may have been ineffective in redirecting attention to other (non-race-based) ways of controlling for human variability. We contend that popular arguments against the idea that human races have a genetic basis, though convincing in many respects, are not sufficient to exclude the pragmatic use of race and ethnicity as proxies for genetic variability related to complex phenotypes. Finally, we provide two further arguments to support the idea that ethnoracial categories are unlikely to provide meaningful insights into medical genetics, which implies that even the interpretation of race as a useful tool to stratify disease risk is unwarranted. (shrink)

In this paper, we discuss the processes of racialisation on the example of biomedical research. We argue that applying the concept of racialisation in biomedical research can be much more precise, informative and suitable than currently used categories, such as race and ethnicity. For this purpose, we construct a model of the different processes affecting and co-shaping the racialisation of an individual, and consider these in relation to biomedical research, particularly to studies on hypertension. We finish with a discussion on (...) the potential application of our proposition to institutional guidelines on the use of racial categories in biomedical research. (shrink)

In the German legal system, the concept of race occupies an important and controversial position. The desire to eliminate it is understandable but not inherently obvious, as not all reasons for deletion are valid. One central issue with the term “race” is its ambiguity, encompassing both scientific-biological and social-constructivist categorisations of individuals. Choosing one interpretation over the other is neither meaningful nor purposeful. Instead, it is more sensible to understand how the concept of race functions and how it can be (...) legally addressed. Biological arguments for removing “race” may be able to falsify the existence of human races, but at the same time risk the loss of referentiality. To make matters worse, biological criteria for the existence of human races presuppose their existence, which conceptually legitimises naturalistic or essentialist tendencies, even if the term itself is empty. On the other hand, biologically determined characteristics that enable social classifications are relevant: Features such as skin color or body shape seem to be significant factors in the development and use of the term, especially within the legal context. Instead of just dismissing the term “race” entirely, it is important to examine how it is commonly understood, which reveals mechanisms that assign it a destructive meaning on semantic-psychological and social levels that oppose its broader use. Simultaneously, the reference to certain characteristics is not lost as it is with the biological interpretation. This allows for highlighting a feature that is superficial enough to avoid essentializing – the outward appearance itself. It is crucial to note that these reflections are not meant to provide comprehensive social remedies for combating racist discrimination but rather to expose it. (shrink)