In a preceding publication a fundamentally oriented and irreversible world was shown to be de- rivable from the important principle of least action. A consequence of such a paradigm change is avoidance of paradoxes within a “dynamic” quantum physics. This becomes essentially possible because fundamental irreversibility allows consideration of the “entropy” concept in elementary processes. For this reason, and for a compensation of entropy in the spread out energy of the wave, the duality of particle and wave has to be mediated via an information self-image of matter. In this publication considerations are extended to irreversible thermodynamics, to gravitation and cos- mology with its dependence on quantum interpretations. The information self-image of matter around particles could be identified with gravitation. Because information can also impose an al- ways constant light velocity there is no need any more to attribute such a property to empty space, as done in relativity theory. In addition, the possibility is recognized to consider entropy genera- tion by expanding photon fields in the universe. Via a continuous activation of information on matter photons can generate entropy and release small energy packages without interacting with matter. This facilitates a new interpretation of galactic redshift, emphasizes an information link between quantum- and cosmological phenomena, and evidences an information-triggered origin of the universe. Self-organized processes approach maximum entropy production within their constraints. In a far from equilibrium world also information, with its energy content, can self- organize to a higher hierarchy of computation. It is here identified with consciousness. This ap- pears to explain evolution of spirit and intelligence on a materialistic basis. Also gravitation, here identified as information on matter, could, under special conditions, self-organize to act as a su- per-gravitation, offering an alternative to dark matter. Time is not an illusion, but has to be understood as flux of action, which is the ultimate reality of change. The concept of an irreversible physical world opens a route towards a rational understanding of complex contexts in nature.