Abstract
This paper examines how science and metaphysics interact in our theories about space and time. It is argued that scientific development affects philosophical thoughts about space and time. We first review the traditional arguments of substantivalists and relationists about space and time, especially those contained in the correspondence between Leibniz and Clarke. Then we show the mutual influence of science and metaphysics in the modern scientific era: for example, in neo-Newtonian structure, field theory, and special and general theories of relativity. In the end, we claim that the substantivalist's position seems more defensible considering new scientific theories, such as Einstein's theory of general relativity.