I survey four categories of factors that might give a digital mind, such as an upload or an artificial general intelligence, an advantage over humans. Hardware advantages include greater serial speeds and greater parallel speeds. Self-improvement advantages include improvement of algorithms, design of new mental modules, and modification of motivational system. Co-operative advantages include copyability, perfect co-operation, improved communication, and transfer of skills. Human handicaps include computational limitations and faulty heuristics, human-centric biases, and socially motivated cognition. The shape of hardware growth curves, as well as the ease of modifying minds, are found to have a major impact on how quickly a digital mind may take advantage of these factors.