Genuine Bayesian Multiallelic Significance Test for the Hardy-Weinberg Equilibrium Law

Genetics and Molecular Research 5 (4):619-631 (2006)
Download Edit this record How to cite View on PhilPapers
Statistical tests that detect and measure deviation from the Hardy-Weinberg equilibrium (HWE) have been devised but are limited when testing for deviation at multiallelic DNA loci is attempted. Here we present the full Bayesian significance test (FBST) for the HWE. This test depends neither on asymptotic results nor on the number of possible alleles for the particular locus being evaluated. The FBST is based on the computation of an evidence index in favor of the HWE hypothesis. A great deal of forensic inference based on DNA evidence assumes that the HWE is valid for the genetic loci being used. We applied the FBST to genotypes obtained at several multiallelic short tandem repeat loci during routine parentage testing; the locus Penta E exemplifies those clearly in HWE while others such as D10S1214 and D19S253 do not appear to show this.
No keywords specified (fix it)
PhilPapers/Archive ID
Upload history
Archival date: 2021-07-24
View other versions
Added to PP index

Total views
8 ( #65,070 of 2,454,523 )

Recent downloads (6 months)
8 ( #52,088 of 2,454,523 )

How can I increase my downloads?

Downloads since first upload
This graph includes both downloads from PhilArchive and clicks on external links on PhilPapers.