I will use the history of phage to focus on the issue of biological explanations; on the relationship between biology and physics; and on the historical problem of the disciplinary autonomy of biology, versus its reduction, which ultimately seeks to place it within the domain of the physical sciences. Paradoxically, the two physicists I focus on most, Neils Bohr and Max Delbrück, represent attempts to preserve the autonomy of biology, each in a very complex way. Once again the problematique here (...) is the nature of biological systems as goal-oriented historical phenomena, that is, as teleological explanations rather than mechanistic accounts of life. (shrink)

What do biologists want? If, unlike their counterparts in physics, biologists are generally wary of a grand, overarching theory, at what kinds of explanation do biologists aim? A history of the diverse and changing nature of biological explanation in a particularly charged field, "Making Sense of Life" draws our attention to the temporal, disciplinary, and cultural components of what biologists mean, and what they understand, when they propose to explain life.

What is life? For four centuries, it has been believed that the only possible scientific approach to this question proceeds from the Cartesian metaphor -- organism as machine. Therefore, organisms are to be studied and characterized the same way "machines" are; the same way any inorganic system is. Robert Rosen argues that such a view is neither necessary nor sufficient to answer the question. He asserts that life is not a specialization of mechanism, but rather a sweeping generalization of it. (...) Above all, Rosen argues that renouncing mechanism does not mean abandoning science. A radical alternative is proposed, drawn equally from experience in biology, physics, and mathematics; an alternative which draws attention to a new class of complex systems, which are radically different from mechanism. (shrink)

Drawing on work of the past decade, this volume brings together articles from the philosophy, history, and sociology of science, and many other branches of the biological sciences. The volume delves into the latest theoretical controversies as well as burning questions of contemporary social importance. The issues considered include the nature of evolutionary theory, biology and ethics, the challenge from religion, and the social implications of biology today (in particular the Human Genome Project).

Philosophers have ever declared that their problems lie at a different level from the problems of the empirical sciences. Perhaps one may agree with this assertion; the question is, however, where should one seek this level. The metaphysicians wish to seek their object behind the objects of empirical science; they wish to enquire after the essence, the ultimate cause of things. But the logical analysis of the pretended propositions of metaphysics has shown that they are not propositions at all, but (...) empty word arrays, which on account of notional and emotional connections arouse the false appearance of being propositions. This conception that the “propositions” of metaphysics, including those of ethics, have no theoretical content, is to be sure still disputed. We shall not, however, enter here on its demonstration, but, under its guidance, will limit ourselves to non-metaphysical and non-ethical philosophical problems. (shrink)

By 1900 most biologists accepted experimentation as appropriate for at least parts of biology. Some claimed experimentation as the best or only proper approach to biology, while others regarded it as an acceptable addition to existing methodologies. Different researchers defined experimentation in different ways, and they held different aspirations for their experimental programs. This paper explores three sets of ideas, represented respectively by the French in the 1870s, the Germans in the 1880s, and the Americans in the 1890s. It examines (...) what an experiment was thought to be, what experimentation was, and what the goals of experimentation were for each group, revealing suggestive differences. (shrink)