"In preparing this remarkable book, Ernest Hook persuaded an eminent group of scientists, historians, sociologists and philosophers to focus on the problem: why are some discoveries rejected at a particular time but later seen to be valid? The interaction of these experts did not produce agreement on 'prematurity' in science but something more valuable: a collection of fascinating papers, many of them based on new research and analysis, which sometimes forced the author to revise a previously-held opinion. The book should (...) be enthusiastically welcomed by all readers who are interested in how science works."—Stephen G. Brush, co-author of Physics, The Human Adventure: From copernicus to Einstein and Beyond "Prematurity and Scientific Discovery contains interesting and insightful papers by numerous well-known scientists and scholars. It will be of wide interest, not only to science studies scholars but also to working scientists and to science-literate general readers."—Thomas Nickles, editor of Scientific Discovery, Logic, and Rationality. (shrink)

Between Bench and Bedside is a compelling account of the clinical trials of interleukin-2 at a major French cancer hospital. Löwy's book offers a remarkable insider's view of the culture of clinical experimentation in oncology.

In the standard narrative of her life, Barbara McClintock discovered genetic transposition in the 1940s but no one believed her. She was ignored until molecular biologists of the 1970s "rediscovered" transposition and vindicated her heretical discovery. New archival documents, as well as interviews and close reading of published papers, belie this narrative. Transposition was accepted immediately by both maize and bacterial geneticists. Maize geneticists confirmed it repeatedly in the early 1950s and by the late 1950s it was considered a classic (...) discovery. But for McClintock, movable elements were part of an elaborate system of genetic control that she hypothesized to explain development and differentiation. This theory was highly speculative and was not widely accepted, even by those who had discovered transposition independently. When Jacob and Monod presented their alternative model for gene regulation, the operon, her controller argument was discarded as incorrect. Transposition, however, was soon discovered in microorganisms and by the late 1970s was recognized as a phenomenon of biomedical importance. For McClintock, the award of the 1983 Nobel Prize to her for the discovery of movable genetic elements, long treated as a legitimation, may well have been bittersweet. This new look at McClintock's experiments and theory has implications for the intellectual history of biology, the social history of American genetics, and McClintock's role in the historiography of women in science. (shrink)