The Hamiltonian structure of General Relativity (GR), for both metric and tetrad gravity in a definite continuous family of space-times, is fully exploited in order to show that: i) the "Hole Argument" can be bypassed by means of a specific "physical individuation" of point-events of the space-time manifold M^4 in terms of the "autonomous degrees of freedom" of the vacuum gravitational field (Dirac observables), while the "Leibniz equivalence" is reduced to differences in the "non-inertial appearances" (connected to gauge variables) of (...) the same phenomena. ii) the chrono-geometric structure of a solution of Einstein equations for given, gauge-fixed, initial data (a "3-geometry" satisfying the relevant constraints on the Cauchy surface), can be interpreted as an "unfolding" in mathematical global time of a sequence of "achronal 3-spaces" characterized by "dynamically determined conventions" about distant simultaneity. This result stands out as an important conceptual difference with respect to the standard chrono-geometrical view of Special Relativity (SR) and allows, in a specific sense, for an "endurantist" interpretations of ordinary physical objects in GR. (shrink)