This paper discusses the influence of Sextus Empiricus' works on Renaissance culture and the recovery of Pyrrhonism during the fifteenth and sixteenth centuries. It investigates what primary and secondary sources were available at the time, and who knew and made use of such sources. The article concludes that the dearth of Pyrrhonic arguments in Renaissance literature was due to the prevailing and incompatible culture of humanism rather than to a lack of interest in Sextus Empiricus’ works during this period.