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  1. Mechanisms: what are they evidence for in evidence-based medicine?Holly Andersen - 2012 - Journal of Evaluation in Clinical Practice 18 (5):992-999.
    Even though the evidence‐based medicine movement (EBM) labels mechanisms a low quality form of evidence, consideration of the mechanisms on which medicine relies, and the distinct roles that mechanisms might play in clinical practice, offers a number of insights into EBM itself. In this paper, I examine the connections between EBM and mechanisms from several angles. I diagnose what went wrong in two examples where mechanistic reasoning failed to generate accurate predictions for how a dysfunctional mechanism would respond to intervention. (...)
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  • Inductive risk and values in science.Heather Douglas - 2000 - Philosophy of Science 67 (4):559-579.
    Although epistemic values have become widely accepted as part of scientific reasoning, non-epistemic values have been largely relegated to the "external" parts of science (the selection of hypotheses, restrictions on methodologies, and the use of scientific technologies). I argue that because of inductive risk, or the risk of error, non-epistemic values are required in science wherever non-epistemic consequences of error should be considered. I use examples from dioxin studies to illustrate how non-epistemic consequences of error can and should be considered (...)
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  • The theory-ladenness of observation and the theory-ladenness of the rest of the scientific process.William F. Brewer & Bruce L. Lambert - 2001 - Philosophy of Science 68 (3):S176-S186.
    We use evidence from cognitive psychology and the history of science to examine the issue of the theory-ladenness of perceptual observation. This evidence shows that perception is theory-laden, but that it is only strongly theory-laden when the perceptual evidence is ambiguous or degraded, or when it requires a difficult perceptual judgment. We argue that debates about the theory-ladenness issue have focused too narrowly on the issue of perceptual experience, and that a full account of the scientific process requires an examination (...)
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  • Productive theory-ladenness in fMRI.M. Emrah Aktunc - 2019 - Synthese 198 (9):7987-8003.
    Several developments for diverse scientific goals, mostly in physics and physiology, had to take place, which eventually gave us fMRI as one of the central research paradigms of contemporary cognitive neuroscience. This technique stands on solid foundations established by the physics of magnetic resonance and the physiology of hemodynamics and is complimented by computational and statistical techniques. I argue, and support using concrete examples, that these foundations give rise to a productive theory-ladenness in fMRI, which enables researchers to identify and (...)
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  • Productive Theory-Ladenness in fMRI.Emrah Aktunc - forthcoming - Synthese.
    Several developments for diverse scientific goals, mostly in physics and physiology, had to take place, which eventually gave us fMRI as one of the central research paradigms of contemporary cognitive neuroscience. This technique stands on solid foundations established by the physics of magnetic resonance and the physiology of hemodynamics and is complimented by computational and statistical techniques. I argue, and support using concrete examples, that these foundations give rise to a productive theory-ladenness in fMRI, which enables researchers to identify and (...)
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  • Non-cognitive Values and Methodological Learning in the Decision-Oriented Sciences.Oliver Todt & José Luis Luján - 2017 - Foundations of Science 22 (1):215-234.
    The function and legitimacy of values in decision making is a critically important issue in the contemporary analysis of science. It is particularly relevant for some of the more application-oriented areas of science, specifically decision-oriented science in the field of regulation of technological risks. Our main objective in this paper is to assess the diversity of roles that non-cognitive values related to decision making can adopt in the kinds of scientific activity that underlie risk regulation. We start out, first, by (...)
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  • Exploring Inductive Risk: Case Studies of Values in Science.Kevin Christopher Elliott & Ted Richards (eds.) - 2017 - New York: Oup Usa.
    This book brings together eleven case studies of inductive risk-the chance that scientific inference is incorrect-that range over a wide variety of scientific contexts and fields. The chapters are designed to illustrate the pervasiveness of inductive risk, assist scientists and policymakers in responding to it, and productively move theoretical discussions of the topic forward.
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  • The Interrelations between the Philosophy, History and Sociology of Science in Thomas Kuhn‘s Theory of Scientific Development.Paul Hoyningen-Huene - 1992 - British Journal for the Philosophy of Science 43 (4):487-501.
    The paper deals with the interrelations between the philosophy, sociology and historiography of science in Thomas Kuhn’s theory of scientific development. First, the historiography of science provides the basis for both the philosophy and sociology of science in the sense that the fundamental questions of both disciplines depend on the principles of the form of historiography employed. Second, the fusion of the sociology and philosophy of science, as advocated by Kuhn, is discussed. This fusion consists essentially in a replacement of (...)
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  • Science Without Boundaries: Interdisciplinarity in Research, Society and Politics.Willy Østreng - 2009 - Upa.
    This book discusses the many issues involved in going beyond disciplinary research practices in science, politics and society, and addresses the complexities of their interface. Polar research is used to show how politics may intermingle with science to safeguard national interests in times of dramatic international change.
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  • The Anatomy of Research Scandals.Carl Elliott - 2017 - Hastings Center Report 47 (3):inside back cover-inside back co.
    For the past two years, I have taught a seminar on medical research scandals. The syllabus looks like a highlight reel of exploitation and abuse: children fed plutonium-laced breakfast cereal, prisoners dosed with the active ingredient in Agent Orange, mental patients given psychedelic drugs and massive electroconvulsive therapy before being sent into curare-induced paralysis and a coma. I designed the seminar to crush the idealism of future physicians by illuminating the dark patterns that research scandals typically follow. The most recent (...)
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