This article offers a review of the relationship of methodological positivism and post-World War II U.S. sociology, especially its transformations in the last three decades of the twentieth century. With this as context, sociological methodology is rethought in terms of what cultural critics refer to as infra-empiricism that allows for a rethinking of bodies, matter and life through new encounters with visceral perception and pre-conscious affect. Thinking infra-empiricism as a new empiricism at this time means rethinking methodology in relationship to (...) the changing configuration of economy, governance disciplinarity and control in the early twenty-first century. (shrink)