A ternary relation [Formula: see text] between subsets of the big model of a complete first-order theory T is called an independence relation if it satisfies a certain set of axioms. The primary example is forking in a simple theory, but o-minimal theories are also known to have an interesting independence relation. Our approach in this paper is to treat independence relations as mathematical objects worth studying. The main application is a better understanding of thorn-forking, which turns out to be (...) closely related to modular pairs in the lattice of algebraically closed sets. (shrink)