Many scientific models in biology are how-possibly models. These models depict things as they could be, but do not necessarily capture actual states of affairs in the biological world. In contemporary philosophy of science, it is customary to treat how-possibly models as second-rate theoretical tools. Although possibly important in the early stages of theorizing, they do not constitute the main aim of modelling, namely, to discover the actual mechanism responsible for the phenomenon under study. In the paper it is argued (...) that this prevailing picture does not do justice to the synthetic strategy that is commonly used in biological engineering. In synthetic biology, how-possibly models are not simply speculations or eliminable scaffolds towards a single how-actually model, but indispensable design hypotheses for a field whose ultimate goal is to build novel biological systems. The paper explicates this by providing an example from the study of alternative genetic systems by synthetic biologist Steven Benner and his group. The case will also highlight how the method of synthesis, even when it fails, provides an effective way to limit the space of possible models for biological systems. (shrink)

Polger and Shapiro argue that their official recipe, a criterion for judging when the phenomenon of multiple realization exists, renders MR less widespread than its proponents have assumed. I argue that, although Polger and Shapiro’s criterion is a useful contribution, they arrive at their conclusion too hastily. Contrary to Polger and Shapiro, I claim that the phenomenon of multiple realization in the biological world, judged by their criterion, is not as scarce as they suggest. To show this, an updated official (...) recipe, namely a multiple mechanistic realization thesis, integrating Polger and Shapiro’s criterion with a compositional conception of realization, is developed. Then, three examples of varied kinds are examined, showing that cases of MR are not so hard to find in the biological world. (shrink)

Since Hilary Putnam offered multiple realization as an empirical hypothesis in the 1960s, philosophical consensus has turned against the idea that mental processes are identifiable with brain processes, and multiple realization has become the keystone of the 'antireductive consensus' across philosophy of science. Thomas W. Polger and Lawrence A. Shapiro offer the first book-length investigation of multiple realization, which serves as a starting point to a series of philosophically sophisticated and empirically informed arguments that cast doubt on the generality of (...) multiple realization in the cognitive sciences. They argue that mind-brain identities have played an important role in the growth and achievements of the cognitive sciences, and suggest that there is little prospect for multiple realization in an empirically-based theory of mind. This leads Polger and Shapiro to offer an alternative framework for understanding explanations in the cognitive sciences, as well as in chemistry, biology, and other non-basic sciences. (shrink)

This paper addresses the recent resurgence of Nagel style reduction in the philosophical literature. In particular, it considers the so-called multiple realizability objection to reductionism presented most forcefully by Sober in 1999. It is argued that this objection misses the point of multiple realizability and that there remain serious problems for reductionist methodologies in science.

The claim of the multiple realizability of mental states by brain states has been a major feature of the dominant philosophy of mind of the late 20th century. The claim is usually motivated by evidence that mental states are multiply realized, both within humans and between humans and other species. We challenge this contention by focusing on how neuroscientists differentiate brain areas. The fact that they rely centrally on psychological measures in mapping the brain and do so in a comparative (...) fashion undercuts the likelihood that, at least within organic life forms, we are likely to find cases of multiply realized psychological functions. (shrink)

One way that scientifically recognized properties are multiply realized is by “compensatory differences” among realizing properties. If a property G is jointly realized by two properties F1 and F2, then G can be multiply realized by having changes in the property F1 offset changes in the property F2. In some cases, there are scientific laws that articulate how distinct combinations of physical quantities can determine one and the same value of some other physical quantity. One moral to draw is that (...) in such cases we have the multiple realization of a single determinate, “fine grained” property instance that is exactly similar to another instance. As simple as this moral is, it has ramifications for a number of recent discussions of multiple realization in science. Taken collectively, these ramifications indicate that multiple realization by compensatory adjustments merits greater attention in the philosophy of science literature than it has hitherto received. (shrink)

Carl Gillett has defended what he calls the “dimensioned” view of the realization relation, which he contrasts with the traditional “flat” view of realization (2003, 2007; see also Gillett 2002). Intuitively, the dimensioned approach characterizes realization in terms of composition whereas the flat approach views realization in terms of occupiers of functional roles. Elsewhere we have argued that the general view of realization and multiple realization that Gillett advances is not able to discharge the theoretical duties of those relations (Shapiro (...) 2004, unpublished manuscript; Polger 2004, 2007, forthcoming). Here we focus on an internal objection to Gillett’s account and then raise some broader reasons to reject it. (shrink)

Sometimes neuroscientists discover distinct realizations for a single psychological property. In considering such cases, some philosophers have maintained that scientists will abandon the single multiply realized psychological property in favor of one or more uniquely realized psychological properties. In this paper, we build on the Dimensioned theory of realization and a companion theory of multiple realization to argue that this is not the case. Whether scientists postulate unique realizations or multiple realizations is not determined by the neuroscience alone, but by (...) the psychological theory under examination. Thus, one might say that, in the splitting or non-splitting of properties, psychology enjoys a kind of autonomy from neuroscience. (shrink)

Multiple realization historically mandated the autonomy of psychology, and its principled irreducibility to neuroscience. Recently, multiple realization and its implications for the reducibility of psychology to neuroscience have been challenged. One challenge concerns the proper understanding of reduction. Another concerns whether multiple realization is as pervasive as is alleged. I focus on the latter question. I illustrate multiple realization with actual, rather than hypothetical, cases of multiple realization from within the biological sciences. Though they do support a degree of autonomy (...) for higher levels of explanation and organization, they do not have the dire consequences critics of multiple realization fear. †To contact the author, please write to: Department of Philosophy, University of Cincinnati, P.O. Box 210374, Cincinnati, OH 45221‐0374; e‐mail: [email protected]. (shrink)

This article investigates several consequences of a recent trend in philosophy of mind to shift the relata of realization from mental state–physical state to function‐mechanism. It is shown, by applying both frameworks to the neuroscientific case study of memory consolidation, that, although this shift can be used to avoid the immediate antireductionist consequences of the traditional argument from multiple realizability, what is gained is a far more modest form of reductionism than recent philosophical accounts have intimated and neuroscientists themselves have (...) claimed. (shrink)

This paper concerns what Jerry Fodor calls a 'metaphysical mystery': How can there by macroregularities that are realized by wildly heterogeneous lower level mechanisms? But the answer to this question is not as mysterious as many, including Jaegwon Kim, Ned Block, and Jerry Fodor might think. The multiple realizability of the properties of the special sciences such as psychology is best understood as a kind of universality, where 'universality' is used in the technical sense one finds in the physics literature. (...) It is argued that the same explanatory strategy used by physicists to provide understanding of universal behavior in physics can be used to explain how special science properties can be heterogeneously multiply realized. (shrink)

Multiple realizability has recently attractedrenewed attention, for example Bickle, 1998;Bechtel and Mundale, 1999; Bechtel and McCauley,1999; Heil, 1999; and Sober, 1999. Many of thesewriters revisit the topic of multiplerealizability in order to show that someversion of a mind-brain identity theory isviable. Although there is much of value inthese recent explorations, they do not addressthe underlying intuitions that have vexedphilosophers of mind since Hilary Putnamintroduced the concern (1967). I argue that thestandard way of construing multiplerealizability is a much stronger claim thanthat (...) of Putnam's intuition alone. I distinguishfour interpretations of the multiplerealizability intuition. Some commonformulations of multiple realizability arealmost certainly true, while others are not atall plausible. I argue that the plausible formsof multiple realizability do not impugn theprospects for a mind-brain Identity Theory. (shrink)

Shapiro tests these hypotheses against two rivals, the mental constraint thesis and the embodied mind thesis. Collecting evidence from a variety of sources (e.g., neuroscience, evolutionary theory, and embodied cognition) he concludes that the multiple realizability thesis, accepted by most philosophers as a virtual truism, is much less obvious than commonly assumed, and that there is even stronger reason to give up the separability thesis. In contrast to views of mind that tempt us to see the mind as simply being (...) resident in a brain or body, Shapiro argues for a far more encompassing integration of mind, brain, and body than philosophers have supposed. (publisher, edited). (shrink)

Reductionism is often understood to include two theses: (1) every singular occurrence that the special sciences can explain also can be explained by physics; (2) every law in a higher-level science can be explained by physics. These claims are widely supposed to have been refuted by the multiple realizability argument, formulated by Putnam (1967, 1975) and Fodor (1968, 1975). The present paper criticizes the argument and identifies a reductionistic thesis that follows from one of the argument's premises.

A common view is that the truth of multiple realization—e.g., about psychological states—entails the truth of functionalism. This is supposed to follow because what is multiply realized is eo ipso realized. I argue that view is mistaken by demonstrating how it misrepresents arguments from multiple realization. In particular, it undermines the empirical component of the arguments, and renders the multiplicity of the realization irrelevant. I suggest an alternative reading of multiple realizability arguments, particularly in philosophy of psychology. And I explain (...) the proper way to understand the relation between realization and multiple realization. (shrink)

Due to the variation, contingency and complexity of living systems, biology is often taken to be a science without fundamental theories, laws or general principles. I revisit this question in light of the quest for design principles in systems biology and show that different views can be reconciled if we distinguish between different types of generality. The philosophical literature has primarily focused on generality of specific models or explanations, or on the heuristic role of abstraction. This paper takes a different (...) approach in emphasizing a theory-constituting role of general principles. Design principles signify general dependency-relations between structures and functions, given a set of formally defined constraints. I contend that design principles increase our understanding of living systems by relating specific models to general types. The categorization of types is based on a delineation of the scope of biological possibilities, which serves to identify and define the generic features of classes of systems. To characterize the basis for general principles through generic abstraction and reasoning about possibility spaces, I coin the term constraint-based generality. I show that constraint-based generality is distinct from other types of generality in biology, and argue that general principles play a unifying role that does not entail theory reduction. (shrink)

Forthcoming in Philosophy of Science. Despite some recent advances, multiple realization remains a largely misunderstood thesis. Consider the dispute between Lawrence Shapiro and Carl Gillett over the application of Shapiro’s recipe for deciding when we have genuine cases of multiple realization. I argue that Gillett follows many philosophers in mistakenly supposing that multiple realization is absolute and transitive. Both of these are problematic. They are tempting only when we extract the question of multiple realization from the explanatory context in which (...) it is invoked. Anchoring multiple realizability in its theoretical context provides grounds for arbitrating disagreements. Doing so, I argue, favors the view advanced by Shapiro. (shrink)

This paper aims to draw attention to an explanatory problem posed by the existence of multiply realized or universal behavior exhibited by certain physical systems. The problem is to explain how it is possible that systems radically distinct at lower-scales can nevertheless exhibit identical or nearly identical behavior at upper-scales. Theoretically this is reflected by the fact that continuum theories such as fluid mechanics are spectacularly successful at predicting, describing, and explaining fluid behaviors despite the fact that they do not (...) recognize the discrete nature of fluids. A standard attempt to reduce one theory to another, is shown to fail to answer the appropriate question about autonomy. (shrink)

The idea of reduction has appeared in different forms throughout the history of science and philosophy. Thales took water to be the fundamental principle of all things; Leucippus and Democritus argued that everything is composed of small, indivisible atoms; Galileo and Newton tried to explain all motion with a few basic laws; 17th century mechanism conceived of everything in terms of the motions and collisions of particles of matter; British Empiricism held that all knowledge is, at root, experiential knowledge; current (...) physicists are searching for the GUT, the “grand unified theory,” that will show that at very high energies the electromagnetic and the weak and strong nuclear forces are fused into a single unified field. Some of these projects are clearly ontological in nature (Leucippus and Democritus), others are more methodological (mechanism), and still others strive for theoretical simplification (the projects of Galileo and Newton or the search for a GUT). Nevertheless, as they all aim at revealing some kind of unity or simplicity behind the appearance of plurality or complexity, they may all be regarded as (attempted) reductions. (shrink)

Arguments for multiple realization depend on the idea that the same kind of function is realized by different kinds of structures. It is important to such arguments that we know the kinds used in the arguments have been individuated properly. In the philosophical literature, though, claims about how to individuate kinds are frequently decided on intuitive grounds. This paper criticizes this way of approaching kinds by considering how practicing researchers think about the matter. I will consider several examples in which (...) the practice of researchers on comparative vision conflicts with the standard account of these issues. (shrink)

Consider what the brain-state theorist has to do to make good his claims. He has to specify a physical–chemical state such that any organism (not just a mammal) is in pain if and only if (a) it possesses a brain of suitable physical–chemical structure; and (b) its brain is in that physical–chemical state. This means that the physical–chemical state in question must be a possible state of a mammalian brain, a reptilian brain, a mollusc’s brain (octopuses are mollusca, and certainly (...) feel pain), etc. At the same time, it must not be a possible (physically possible) state of the brain of any physically possible creature that cannot feel pain. Even if such a state can be found, it must be nomologically certain that it will also be a state of the brain of any extraterrestrial life that may be found that will be capable of feeling pain before we can even entertain the supposition that it may be pain. It is not altogether impossible that such a state will be found... . But this is certainly an ambitious hypothesis. (Putnam 1967/1975, p. 436) The belief that mental states are multiply realized is now nearly universal among philosophers, as is the belief that this fact decisively refutes the identity theory. I argue that the empirical support for multiple realization does not justify the confidence that has been placed in it. In order for multiple realization of mental states to be an objection to the identity theory, the neurological differences among pains, for example, must be such as to guarantee that they are of distinct neurological kinds. But the phenomena traditionally cited do not provide evidence of that sort of variation. In particular, examples of neural plasticity do not provide such evidence. (shrink)

Evolutionary convergence is often appealed to in support of claims about multiple realization. The idea is that convergence shows that the same function can be realized by different kinds of structures. I argue here that the nature of convergence is more complicated than it might appear at first look. Broad claims about convergence are made by biologists during general discussions of the mechanisms of evolution. In their specialized work, though, biologists are often more limited in the claims they make. I (...) will examine a standard example to show how claims about convergence can be oversimplified. (shrink)

Kim claims that Bechtel and Mundale's case against multiple realization depends on the wrong kind of evidence. The latter argue that neuroscientific practice shows neural states across individuals and species are type identical. Kim replies that the evidence they cite to support this is irrelevant. I defend Bechtel and Mundale by showing why the evidence they cite is relevant and shows multiple realization does not occur.

In the context of scientists' reflections on genomics, we examine some fundamental issues in the emerging postgenomic discipline of systems biology. Systems biology is best understood as consisting of two streams. One, which we shall call ‘pragmatic systems biology’, emphasises large‐scale molecular interactions; the other, which we shall refer to as ‘systems‐theoretic biology’, emphasises system principles. Both are committed to mathematical modelling, and both lack a clear account of what biological systems are. We discuss the underlying issues in identifying systems (...) and how causality operates at different levels of organisation. We suggest that resolving such basic problems is a key task for successful systems biology, and that philosophers could contribute to its realisation. We conclude with an argument for more sociologically informed collaboration between scientists and philosophers. BioEssays 27:1270–1276, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

In response to points raised by our critics in this book symposium, we offer some clarifications about how to understand the role of science in assessing the multiple realization thesis. We also consider the connection between functionalism and multiple realization in the contexts of both psychological and biological sciences.

Philosophical discussions of systems biology have enriched the notion of mechanistic explanation by pointing to the role of mathematical modeling. However, such accounts still focus on explanation in terms of tracking a mechanism's operation across time (by means of mental or computational simulation). My contention is that there are explanations of molecular systems where the explanatory understanding does not consist in tracking a mechanism's operation and productive continuity. I make this case by a discussion of bifurcation analysis in dynamical systems, (...) articulating the distinctive way in which explanatory understanding is provided, especially about the reversibility or irreversibility of molecular processes. (shrink)

This paper provides some responses to Tom Polger and Larry Shapiro’s The Multiple Realization Book (2016). I first provide a description of the authors’ framework for thinking about multiple realization and the conditions they claim this involves. I explain what I think they get right and what they get wrong with this framework. After this, I then consider a few examples of multiple realization they discuss and the interpretations they offer. While I am sympathetic to several things they say about (...) multiple realization, I also think there are some questions that have yet to be answered. (shrink)

One trend in recent work on topic of the multiple realization of psychological properties has been an emphasis on greater sensitivity to actual science and greater clarity regarding the metaphysics of realization and multiple realization. One contribution to this trend is Bechtel and Mundale’s examination of the implications of brain mapping for multiple realization. Where Bechtel and Mundale argue that studies of brain mapping undermine claims about the multiple realization, this paper challenges that argument.

Philosophy and Neuroscience: A Ruthlessly Reductive Account is the first book-length treatment of philosophical issues and implications in current cellular and molecular neuroscience. John Bickle articulates a philosophical justification for investigating "lower level" neuroscientific research and describes a set of experimental details that have recently yielded the reduction of memory consolidation to the molecular mechanisms of long-term potentiation (LTP). These empirical details suggest answers to recent philosophical disputes over the nature and possibility of psycho-neural scientific reduction, including the multiple realization (...) challenge, mental causation, and relations across explanatory levels. Bickle concludes by examining recent work in cellular neuroscience pertaining to features of conscious experience, including the cellular basis of working memory, the effects of explicit selective attention on single-cell activity in visual cortex, and sensory experiences induced by cortical microstimulation. (shrink)

The previous decade has seen renewed critical interest in the multiple realization argument. These criticisms constitute a "second wave" of challenges to this central argument in late-20th century philosophy of mind. Unlike the first wave, which challenged the premise that multiple realization is inconsistent with reduction or type identity, this second wave challenges the truth of the multiple realization premise itself. Since psychoneural reductionism was prominent among the explicit targets of the multiple realization argument, one might think that this second (...) wave of challenges provides important aid and comfort to reductionists. In this paper, however, I provide reasons for thinking it does not. This is not to the detriment of psychoneural reductionism because, as I also argue here, and unrecognized by the current non-reductive orthodoxy in philosophy of mind, one key argument among the first wave of criticisms of the multiple realization argument has never been adequately rejoined. (shrink)

Proponents of mechanistic explanation all acknowledge the importance of organization. But they have also tended to emphasize specificity with respect to parts and operations in mechanisms. We argue that in understanding one important mode of organization—patterns of causal connectivity—a successful explanatory strategy abstracts from the specifics of the mechanism and invokes tools such as those of graph theory to explain how mechanisms with a particular mode of connectivity will behave. We discuss the connection between organization, abstraction, and mechanistic explanation and (...) illustrate our claims by looking at an example from recent research on so-called network motifs. (shrink)

Issues of identity and reduction have monopolized much of the philosopher of mind’s time over the past several decades. Interestingly, while investigations of these topics have proceeded at a steady rate, the motivations for doing so have shifted. When the early identity theorists, e.g. U. T. Place ( 1956 ), Herbert Feigl ( 1958 ), and J. J. C. Smart ( 1959 , 1961 ), fi rst gave voice to the idea that mental events might be identical to brain processes, (...) they had as their intended foil the view that minds are immaterial substances. But very few philosophers of mind today take this proposal seriously. Why, then, the continued interest in identity and reduction? Th e concern, as philosophers like Hilary Putnam and Jerry Fodor have expressed it, is that a victory for identity or reduction is a defeat for psychology. For if minds are physical, or if mental events are physical events, then psychologists might as well disassemble their laboratories, making room for the neuroscientists and molecular biologists who are in a better position to explain those phenomena once misdescribed as “psychological.” Th e worry nowadays is not that locating thought in immaterial souls will make psychology intractable, but that locating thoughts in material brains will make it otiose. (shrink)

An incoherent feed‐forward loop (FFL) is one of the most‐frequently observed motifs in biomolecular regulatory networks. It has been thought that the incoherent FFL is designed simply to induce a transient response shaped by a ‘fast activation and delayed inhibition’. We find that the dynamics of various incoherent FFLs can be further classified into two types: time‐dependent biphasic responses and dose‐dependent biphasic responses. Why do the structurally identical incoherent FFLs play such different dynamical roles? Through computational studies, we show that (...) the dynamics of the two types of incoherent FFLs are mutually exclusive. Following from further computational results and experimental observations, we hypothesize that incoherent FFLs have been optimally designed to achieve distinct biological function arising from different cellular contexts. Additional Supporting Information may be found in the online version of the article. BioEssays 30:1204–1211, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

When conceived as an empirical claim, it is natural to wonder how one might test the hypothesis of multiple realization. I consider general issues of testability, show how they apply specifically to the hypothesis of multiple realization, and propose an auxiliary assumption that, I argue, must be conjoined to the hypothesis of multiple realization to ensure its testability. I argue further that Bechtel and Mundale go astray because they fail to appreciate the need for this auxiliary assumption. †To contact the (...) author, please write to: Department of Philosophy, University of Wisconsin–Madison, 5185 Helen C. White Hall, 600 North Park Street, Madison, WI 53706; e‐mail: [email protected]. (shrink)