A number of recent discussions comparing computer simulation and traditional experimentation have focused on the significance of “materiality.” I challenge several claims emerging from this work and suggest that computer simulation studies are material experiments in a straightforward sense. After discussing some of the implications of this material status for the epistemology of computer simulation, I consider the extent to which materiality (in a particular sense) is important when it comes to making justified inferences about target systems on the basis (...) of experimental results. (shrink)

Part I presents a quantitative-empirical outline of chemistry, esp. preparative chemistry, concerning its dominant role in today's science, its dynamics, and its methods and aims. Emphasis is laid on the poietical character of chemistry for which a methodological model is derived. Part II discusses standard distinction between science and technology, from Aristotle (whose theses are reconsidered in the light of modern sciences) to modern philosophy of technology. Against the background of results of Part I, it is argued that all these (...) distinctions fail, because the underlying concepts of science are either out-dated, one-sided, or arbitrary. A deeper understanding of today's sciences requires, in particular, a philosopical investigation of chemistry. (shrink)

Next SectionOne of the indisputable signs of the progress made in organic chemistry over the last two hundred years is the increased ability of chemists to manipulate, control, and design chemical reactions. The technological expertise manifest in contemporary synthetic organic chemistry is, at least in part, due to developments in the theory of organic chemistry. By appealing to a notable chemist's attempts to articulate and codify the heuristics of synthetic design, this paper investigates how understanding theoretical organic chemistry facilitates progress (...) in synthetic organic chemistry. The picture that emerges of how the applications of organic chemistry are grounded in its theory is contrasted with both standard and some more contemporary philosophical accounts of the applications of science. IntroductionTotal Synthesis as Applied ScienceUnderstanding Organic ChemistryThe Heuristics of Synthetic DesignAn Example: LongifoleneConclusion. (shrink)