Following extensive examination of published and unpublished materials, we provide a history of the use of dexamethasone in pregnant women at risk of carrying a female fetus affected by congenital adrenal hyperplasia (CAH). This intervention has been aimed at preventing development of ambiguous genitalia, the urogenital sinus, tomboyism, and lesbianism. We map out ethical problems in this history, including: misleading promotion to physicians and CAH-affected families; de facto experimentation without the necessary protections of approved research; troubling parallels to the history (...) of prenatal use of diethylstilbestrol (DES); and the use of medicine and public monies to attempt prevention of benign behavioral sex variations. Critical attention is directed at recent investigations by the U.S. Food and Drug Administration (FDA) and Office of Human Research Protections (OHRP); we argue that the weak and unsupported conclusions of these investigations indicate major gaps in the systems meant to protect subjects of high-risk medical research. (shrink)

We have a reason to use information which is available about such genes in our reproductive decision-making; (3) couples should selec.

Sex selection technologies have become increasingly prevalent and accessible. We can find them advertised widely across the Internet and discussed in the popular media—an entry for “sex selection services” on Google generated 859,000 sites in April 2004. The available services fall into three main types: preconception sperm sorting followed either by intrauterine insemination of selected sperm or by in vitro fertilization ; preimplantation genetic diagnosis, by which embryos created by IVF are tested and only those of the desired sex are (...) transferred to the woman's uterus; and prenatal testing of fetuses through ultrasound or chromosomal analysis, followed by selective abortion of fetuses detected to be of the undesired sex. (shrink)

There once was a time when the concept of equal pay for equal work did not exist, when women of all ages were "girls," when abortion was a back-alley procedure, when there was no such thing as a rape crisis center or a shelter for battered women, when "sexual harassment" had not yet been named and defined. "If conditions are right," Susan Brownmiller says in this stunning memoir, "if the anger of enough people has reached the boiling point, the exploding (...) passion can ignite a societal transformation." In Our Time tells the story of that transformation, as only Brownmiller can. A leading feminist activist and the author of Against Our Will, the book that changed the nation's perception of rape, she now brings the Women's Liberation movement and its passionate history vividly to life. Here is the colorful cast of characters on whose shoulders we stand--the feminist icons Betty Friedan, Kate Millett, Germaine Greer, and Gloria Steinem, and the lesser known women whose contributions to change were equally profound. And here are the landmark events of the era: the consciousness-raising groups that sprung up in people's living rooms, the mimeographed position papers that first articulated the new thinking, the abortion and rape speak-outs, the daring sit-ins, the underground newspaper collectives, and the inventive lawsuits that all played a role in the most wide-reaching revolution of the twentieth century. Here as well are Brownmiller's reflections on the feminist utopian vision, and her dramatic accounts, rendered with honesty and humor, of the movement's painful internal schisms as it struggled to give voice to the aspirarations of all women. Finally, Brownmiller addresses thatmost relevant question: What is the legacy of feminism today? (shrink)

This article discusses the ethics of the use of preimplantation genetic diagnosis to prevent the birth of children with intersex conditions/disorders of sex development , such as congenital adrenal hyperplasia and androgen insensitivity syndrome . While pediatric surgeries performed on children with ambiguous genitalia have been the topic of intense bioethical controversy, there has been almost no discussion to date of the ethics of the use of PGD to reduce the prevalence of these conditions. I suggest that PGD for those (...) conditions that involve serious medical risks for those born with them is morally permissible and that PGD for other “cosmetic” variations in sexual anatomy is more defensible than might first appear. However, importantly, the arguments that establish the latter claim have radical and disturbing implications for our attitude toward diversity more generally. (shrink)

Extending the application of preimplantation genetic diagnosis (PGD) to screen embryos for non-medical traits such as gender, height and intelligence, raises serious moral, legal, and social issues. In this paper I consider the possibility of using PGD to select the sexual orientation of offspring. After considering ®ve potential objections, I conclude that parents should be permitted to use PGD to choose the sexual orientation of their children.