In Italy the physical sciences had several decades of prosperity during the first half of the seventeenth century, largely because of the genius of Galileo Galilei and the efforts of a small constellation of his talented followers. But Galileo died in 1642, and before the end of the 1640s three of the most gifted of his disciples, Castelli, Renieri, and Torricelli, had also gone to a better life, to use the favourite euphemism of the time. Thereafter Tommaso Cornelio at Naples, (...) Giovanni Alfonso Borelli at Messina and later at Pisa, as well as some lesser men, carried on the new science, and in 1657 the scientific enthusiasm of the Grand Duke Ferdinand II of Tuscany and his talented brother Leopold led to the short-lived Accademia del Cimento (1657–67), whose clear-cut and totally empirical programme of experimentation, reported on in 1667 but carried out mainly before 1662, was the last Tuscan flame to rise from the Galilean embers. Physiology and anatomy continued to develop, and north of the Apennines there was activity in astronomy and in optics, but the last was an isolated spark in the general gloom. (shrink)