The concept of mechanism is analyzed in terms of entities and activities, organized such that they are productive of regular changes. Examples show how mechanisms work in neurobiology and molecular biology. Thinking in terms of mechanisms provides a new framework for addressing many traditional philosophical issues: causality, laws, explanation, reduction, and scientific change.

By the time of the Leibniz-Clarke correspondence of 1716 the Newtonian and Leibnizian systems of natural philosophy had reached maturity. Each system consisted of different physical as well as metaphysical principles which, taken together, formed a world view. At the time of their famous debates, Leibniz at 70 and Newton at 74, the founders of two highly developed scientific philosophies, were struggling to establish and defend the ontological and mechanical bases of differing bodies of organized knowledge.