Switch to: Citations

Add references

You must login to add references.
  1. Lives in the Balance: Utilitarianism and Animal Research.Robert Bass - 2012 - In Jeremy R. Garrett (ed.), The Ethics of Animal Research: Exploring the Controversy. Mit Press.
    In the long history of moral theory, non-human animals—hereafter, just animals—have often been neglected entirely or have been relegated to some secondary status. Since its emergence in the early 19th century, utilitarianism has made a difference in that respect by focusing upon happiness or well-being (and their contraries) rather than upon the beings who suffer or enjoy. Inevitably, that has meant that human relations to and use of other animals have appeared in a different light. Some cases have seemed easy: (...)
    Download  
     
    Export citation  
     
    Bookmark   10 citations  
  • Thinking about the human neuron mouse.Henry T. Greely, Mildred K. Cho, Linda F. Hogle & Debra M. Satz - 2007 - American Journal of Bioethics 7 (5):27 – 40.
    Download  
     
    Export citation  
     
    Bookmark   45 citations  
  • At the edge of humanity: Human stem cells, chimeras, and moral status.Robert Streiffer - 2005 - Kennedy Institute of Ethics Journal 15 (4):347-370.
    : Experiments involving the transplantation of human stem cells and their derivatives into early fetal or embryonic nonhuman animals raise novel ethical issues due to their possible implications for enhancing the moral status of the chimeric individual. Although status-enhancing research is not necessarily objectionable from the perspective of the chimeric individual, there are grounds for objecting to it in the conditions in which it is likely to occur. Translating this ethical conclusion into a policy recommendation, however, is complicated by the (...)
    Download  
     
    Export citation  
     
    Bookmark   52 citations  
  • Human, Nonhuman, and Chimeric Research: Considering Old Issues with New Research.Jeff Sebo & Brendan Parent - 2022 - Hastings Center Report 52 (S2):29-33.
    Human-nonhuman chimeric research—research on nonhuman animals who contain human cells—is being used to understand human disease and development and to create potential human treatments such as transplantable organs. A proposed advantage of chimeric models is that they can approximate human biology and therefore allow scientists to learn about and improve human health without risking harms to humans. Among the emerging ethical issues being explored is the question of at what point chimeras are “human enough” to have human rights and thus (...)
    Download  
     
    Export citation  
     
    Bookmark   1 citation  
  • Disability, Bioethics, and the Problem of Prejudice.Giles R. Scofield - 2022 - Hastings Center Report 52 (6):46-47.
    This letter responds to the essay “If Not Now, Then When? Taking Disability Seriously in Bioethics,” by Debjani Mukherjee, Preya S. Tarsney, and Kristi L. Kirschner, in the May‐June 2022 issue of the Hastings Center Report.
    Download  
     
    Export citation  
     
    Bookmark   4 citations  
  • Animal Liberation.Bill Puka & Peter Singer - 1977 - Philosophical Review 86 (4):557.
    Download  
     
    Export citation  
     
    Bookmark   622 citations  
  • Crossing species boundaries.Jason Scott Robert & Françoise Baylis - 2003 - American Journal of Bioethics 3 (3):1 – 13.
    This paper critically examines the biology of species identity and the morality of crossing species boundaries in the context of emerging research that involves combining human and nonhuman animals at the genetic or cellular level. We begin with the notion of species identity, particularly focusing on the ostensible fixity of species boundaries, and we explore the general biological and philosophical problem of defining species. Against this backdrop, we survey and criticize earlier attempts to forbid crossing species boundaries in the creation (...)
    Download  
     
    Export citation  
     
    Bookmark   113 citations  
  • Transferring Morality to Human–Nonhuman Chimeras.Monika Piotrowska - 2014 - American Journal of Bioethics 14 (2):4-12.
    Human–nonhuman chimeras have been the focus of ethical controversies for more than a decade, yet some related issues remain unaddressed. For example, little has been said about the relationship between the origin of transferred cells and the morally relevant capacities to which they may give rise. Consider, for example, a developing mouse fetus that receives a brain stem cell transplant from a human and another that receives a brain stem cell transplant from a dolphin. If both chimeras acquire morally relevant (...)
    Download  
     
    Export citation  
     
    Bookmark   22 citations  
  • How Chimeric Animal Research Impacts Animal Welfare: A Conversation with Animal Welfare Experts.Kaitlynn P. Craig - 2022 - Hastings Center Report 52 (S2):52-56.
    In this conversation, four experts in animal research oversight—Christopher Stodgell, Lori Hill, Robert Kesterson, and Angelika Rehrig—discuss the complexities of stem cell-based chimeric animal experiments, especially in relation to traditional animal welfare practices. Each expert shares their experiences and suggestions for how best to conduct chimeric animal research, including discussing the importance of communication and collaboration between experts in animal behavior and welfare and the investigators conducting or proposing chimeric research studies.
    Download  
     
    Export citation  
     
    Bookmark   1 citation  
  • Ethical Arguments Concerning Human-Animal Chimera Research: A Systematic Review.Koko Kwisda, Lucie White & Dietmar Hübner - 2020 - BMC Medical Ethics 21:1-14.
    The burgeoning field of biomedical research involving the mixture of human and animal materials has attracted significant ethical controversy. Due to the many dimensions of potential ethical conflict involved in this type of research, and the wide variety of research projects under discussion, it is difficult to obtain an overview of the ethical debate. This paper attempts to remedy this by providing a systematic review of ethical reasons in academic publications on human-animal chimera research. We conducted a systematic review of (...)
    Download  
     
    Export citation  
     
    Bookmark   9 citations  
  • Human‐Animal Chimeras: The Moral Insignificance of Uniquely Human Capacities.Julian J. Koplin - 2019 - Hastings Center Report 49 (5):23-32.
    Human‐animal chimeras—creatures composed of a mix of animal and human cells—have come to play an important role in biomedical research, and they raise ethical questions. This article focuses on one particularly difficult set of questions—those related to the moral status of human‐animal chimeras with brains that are partly or wholly composed of human cells. Given the uncertain effects of human‐animal chimera research on chimeric animals’ cognition, it would be prudent to ensure we do not overlook or underestimate their moral status. (...)
    Download  
     
    Export citation  
     
    Bookmark   14 citations  
  • Developing human-nonhuman chimeras in human stem cell research: Ethical issues and boundaries.Phillip Karpowicz, Cynthia B. Cohen & Derek J. Van der Kooy - 2005 - Kennedy Institute of Ethics Journal 15 (2):107-134.
    : The transplantation of adult human neural stem cells into prenatal non-humans offers an avenue for studying human neural cell development without direct use of human embryos. However, such experiments raise significant ethical concerns about mixing human and nonhuman materials in ways that could result in the development of human-nonhuman chimeras. This paper examines four arguments against such research, the moral taboo, species integrity, "unnaturalness," and human dignity arguments, and finds the last plausible. It argues that the transfer of human (...)
    Download  
     
    Export citation  
     
    Bookmark   40 citations  
  • Threats to Benefits: Assessing Knowledge Production in Nonhuman Models of Human Neuropsychiatric Disorders.Carolyn P. Neuhaus - 2022 - Hastings Center Report 52 (S2):34-40.
    Recent reports and papers on chimeric research highlight the promise of chimeric models of human neuropsychiatric disorders to ameliorate human suffering due to autism spectrum disorders, depression, and schizophrenia. These calls, however, typically do not acknowledge, much less address, criticisms of model creation and validation, or concerns about scientific conduct more generally. The ethical justification for the use of nonhuman animals in research depends on the production of benefits to humans based on such research. But the assessment and production of (...)
    Download  
     
    Export citation  
     
    Bookmark   1 citation  
  • (3 other versions)The Case for Animal Rights.Tom Regan & Mary Midgley - 1986 - The Personalist Forum 2 (1):67-71.
    Download  
     
    Export citation  
     
    Bookmark   613 citations  
  • A Belmont Report for Animals?Hope Ferdowsian, L. Syd M. Johnson, Jane Johnson, Andrew Fenton, Adam Shriver & John Gluck - 2020 - Cambridge Quarterly of Healthcare Ethics 29 (1):19-37.
    Abstract:Human and animal research both operate within established standards. In the United States, criticism of the human research environment and recorded abuses of human research subjects served as the impetus for the establishment of the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research, and the resulting Belmont Report. The Belmont Report established key ethical principles to which human research should adhere: respect for autonomy, obligations to beneficence and justice, and special protections for vulnerable individuals and (...)
    Download  
     
    Export citation  
     
    Bookmark   23 citations