Philosophers of experiment have acknowledged that experiments are often more than mere hypothesis-tests, once thought to be an experiment's exclusive calling. Drawing on examples from contemporary biology, I make an additional amendment to our understanding of experiment by examining the way that `wide' instrumentation can, for reasons of efficiency, lead scientists away from traditional hypothesis-directed methods of experimentation and towards exploratory methods.

Starting with some illustrative examples, I develop a systematic account of a specific type of experimentation--an experimentation which is not, as in the "standard view", driven by specific theories. It is typically practiced in periods in which no theory or--even more fundamentally--no conceptual framework is readily available. I call it exploratory experimentation and I explicate its systematic guidelines. From the historical examples I argue furthermore that exploratory experimentation may have an immense, but hitherto widely neglected, epistemic significance.

: The increasing attention on experiment in the last two decades has led to important insights into its material, cultural and social dimensions. However, the role of experiment as a tool for generating knowledge has been comparatively poorly studied. What questions are asked in experimental research? How are they treated and eventually resolved? And how do questions, epistemic situations, and experimental activity cohere and shape each other? In my paper, I treat these problems on the basis of detailed studies of (...) research practice. After presenting several cases from the history of electricity—Dufay, Ampère, and Faraday—I discuss a specific type of experiment—the "exploratory experiment"—and analyze how it works in concept formation. I argue that a fuller understanding of experiment can only be achieved by intertwining historical and philosophical perspectives in such a way that the very separation of the two become questioable. (shrink)

In the theory-dominated view of scientific experimentation, all relations of theory and experiment are taken on a par; namely, that experiments are performed solely to ascertain the conclusions of scientific theories. As a result, different aspects of experimentation and of the relation of theory to experiment remain undifferentiated. This in turn fosters a notion of theory-ladenness of experimentation that is too coarse-grained to accurately describe the relations of theory and experiment in scientific practice. By contrast, in this article, I suggest (...) that TLE should be understood as an umbrella concept that has different senses. To this end, I introduce a three-fold distinction among the theories of high-energy particle physics as background theories, model theories and phenomenological models. Drawing on this categorization, I contrast two types of experimentation, namely, “theory-driven” and “exploratory” experiments, and I distinguish between the “weak” and “strong” senses of TLE in the context of scattering experiments from the history of HEP. This distinction enables to identify the exploratory character of the deep-inelastic electron-proton scattering experiments—performed at the Stanford Linear Accelerator Center between the years 1967 and 1973—thereby shedding light on a crucial phase of the history of HEP, namely, the discovery of “scaling”, which was the decisive step towards the construction of quantum chromo-dynamics as a gauge theory of strong interactions. (shrink)

The book examines issues related to the way modeling and simulation enable us to reconstruct aspects of the world we are investigating. It also investigates the processes by which we extract concrete knowledge from those reconstructions and how that knowledge is legitimated.

There has been relatively little effort to provide a systematic overview of different forms of exploratory experimentation (EE). The present paper examines the growing subdiscipline of nanotoxicology and suggests that it illustrates at least four ways that researchers can engage in EE: searching for regularities; developing new techniques, simulation models, and instrumentation; collecting and analyzing large swaths of data using new experimental strategies (e.g., computer-based simulation and "high-throughput" instrumentation); and structuring an entire disciplinary field around exploratory research agendas. In order (...) to distinguish these and other activities more effectively, the paper proposes a taxonomy that includes three dimensions along which types of EE vary: (1) the aim of the experimental activity, (2) the role of theory in the activity, and (3) the methods or strategies employed for varying experimental parameters. (shrink)

In relatively recent years, quite a number of diverse case studies concerning the use of visual displays—such as graphs, diagrams, tables, pictures, drawings, etc.—in both the physical and biological sciences have been offered in the literature of the history and philosophy of science —see, e.g., Miller 1984; Lynch and Woolgar 1990; Baigrie 1996; Pauwels 2006. These case studies have shown that visual representations fulfill important functions in both the theoretical and experimental practices of science, thereby emphasizing the non-verbal dimension of (...) scientific inquiry that had been neglected by the traditional language-based conception of science, which takes the production, justification and... (shrink)

ArgumentIn the theory-dominated view of scientific experimentation, all relations of theory and experiment are taken on a par; namely, that experiments are performed solely to ascertain the conclusions of scientific theories. As a result, different aspects of experimentation and of the relations of theory to experiment remain undifferentiated. This in turn fosters a notion of theory-ladenness of experimentation (TLE) that is toocoarse-grainedto accurately describe the relations of theory and experiment in scientific practice. By contrast, in this article, I suggest that (...) TLE should be understood as anumbrella conceptthat has different senses. To this end, I introduce a three-fold distinction among the theories of high-energy particle physics (HEP) as background theories, model theories, and phenomenological models. Drawing on this categorization, I contrast two types of experimentation, namely, “theory-driven” and “exploratory” experiments, and I distinguish between the “weak” and “strong” senses of TLE in the context of scattering experiments from the history of HEP. This distinction enables identifying the exploratory character of the deep-inelastic electron-proton scattering experiments – performed at the Stanford Linear Accelerator Center (SLAC) between the years 1967 and 1973 – thereby shedding light on a crucial phase of the history of HEP, namely, the discovery of “scaling,” which was the decisive step towards the construction of quantum chromo-dynamics as a gauge theory of strong interactions. (shrink)

This paper analyses the practice of model-building “beyond the Standard Model” in contemporary high-energy physics and argues that its epistemic function can be grasped by regarding models as mediating between the phenomenology of the Standard Model and a number of “theoretical cores” of hybrid character, in which mathematical structures are combined with verbal narratives and analogies referring back to empirical results in other fields . Borrowing a metaphor from a physics research paper, model-building is likened to the search for a (...) Rosetta stone, whose significance does not lie in its immediate content, but rather in the chance it offers to glimpse at and manipulate the components of hybrid theoretical constructs. I shall argue that the rise of hybrid theoretical constructs was prompted by the increasing use of nonrigorous mathematical heuristics in high-energy physics. Support for my theses will be offered in form of a historical–philosophical analysis of the emergence and development of the theoretical core centring on the notion that the Higgs boson is a composite particle. I will follow the heterogeneous elements which would eventually come to form this core from their individual emergence in the 1960s and 1970s, through their collective life as a theoretical core from 1979 until the present day. (shrink)

I present an account of classical genetics to challenge theory-biased approaches in the philosophy of science. Philosophers typically assume that scientific knowledge is ultimately structured by explanatory reasoning and that research programs in well-established sciences are organized around efforts to fill out a central theory and extend its explanatory range. In the case of classical genetics, philosophers assume that the knowledge was structured by T. H. Morgan’s theory of transmission and that research throughout the later 1920s, 30s, and 40s was (...) organized around efforts to further validate, develop, and extend this theory. I show that classical genetics was structured by an integration of explanatory reasoning and investigative strategies . The investigative strategies, which have been overlooked in historical and philosophical accounts, were as important as the so-called laws of Mendelian genetics. By the later 1920s, geneticists of the Morgan school were no longer organizing research around the goal of explaining inheritance patterns; rather, they were using genetics to investigate a range of biological phenomena that extended well beyond the explanatory domain of transmission theories. Theory-biased approaches in history and philosophy of science fail to reveal the overall structure of scientific knowledge and obscure the way it functions.Author Keywords: Investigation; Genetic approach; Structure of knowledge; Classical genetics. (shrink)

The paper studies the topography of the model landscape of the physics in the Higgs sector both within the Standard Model of Elementary Particle Physics and beyond in the months before the discovery of a SM Higgs boson. At first glance, this landscape appears fragmented into a large number of different models and research communities. But it also clusters around certain guiding ideas, among them supersymmetry or dynamical symmetry breaking, in which representative and narrative features of the models are combined. (...) These models do not stand for themselves, waiting to be experimentally confirmed and elevated to the status of theory. Rather do they, quite in the sense advocated by Morgan and Morrison, enjoy a far-reaching autonomy. Typically models in the Higgs sector entertain three types of mediating relationships. First, they mediate between the SM and the data in those instances where the SM contains some uncertainty in the values of its basic parameters. Second, they mediate between BSM physics and the data by instantiating the core ideas behind these often speculative generalizations of the SM as stories—in Hartmann’s sense—that motivate or justify the respective model. Third, the fact that Higgs models within BSM physics reproduce the SM predictions in the low-energy limit functions as a consistency constraint that does not involve any additional autonomy. Due to the second type of mediating relationship, the representative features of Higgs models BSM are complex. (shrink)

Specifically, Allan Franklin is concerned with two problems in the use of experimental results in science: selectivity of data or analysis procedures and the resolution of discordant results.

This paper is devoted to an examination of the discovery, characterization, and analysis of the functions of microRNAs, which also serves as a vehicle for demonstrating the importance of exploratory experimentation in current (post-genomic) molecular biology. The material on microRNAs is important in its own right: it provides important insight into the extreme complexity of regulatory networks involving components made of DNA, RNA, and protein. These networks play a central role in regulating development of multicellular organisms and illustrate the importance (...) of epigenetic as well as genetic systems in evolution and development. The examination of these matters yields principled arguments for the historicity of the functions of key biological molecules and for the indispensability of exploratory experimentation in contemporary molecular biology as well as some insight into the complex interplay between exploratory experimentation and hypothesis-driven science. This latter result is not only important for philosophy of science, but also of practical importance for the evaluation of grant proposals, although the elaboration of this latter claim must be left for another occasion. (shrink)