The use of animals in experiments and research remains highly contentious. Laboratory animal research governance provides guidance and regulatory frameworks to oversee the use and welfare of laboratory animals and relies heavily on the replacement, reduction, and refinement principles to demonstrate responsibility. However, the application of the 3Rs is criticized for being too narrow in focus and closing down societal concerns and political questions about the purpose of animal laboratory research. These critiques challenge the legitimacy of responsibility in laboratory animal (...) research governance and call for new approaches. With the advent of the "Responsible Research and Innovation" agenda, we investigate whether the notion of responsibility in the controversial area of animal research governance could be enhanced by examining the 3Rs through RRI. Our analysis reveals RRI has the potential to helpfully augment the 3Rs in three key ways: recognizing the need to include a broader range of experts and publics in animal research governance; emphasizing the importance for animal research scientists of taking societal, and not just role, responsibilities into account; and acknowledging the political questions animal research raises. (shrink)

The 3Rs, or the replacement, reduction, and refinement of animal research, are widely accepted as the best approach to maximizing high-quality science while ensuring the highest standard of ethical consideration is applied in regulating the use of animals in scientific procedures. This contrasts with the muted scientific interest in the 3Rs when they were first proposed in The Principles of Humane Experimental Technique. Indeed, the relative success of the 3Rs has done little to encourage engagement with their original text, which (...) remains little read and out of print. By adopting a historical perspective, this article argues that one explanation for this disjunction may be found in another, more celebrated, event of 1959: C. P. Snow’s Rede lecture on The Two Cultures. The moral outlook of The Principles of Humane Experimental Technique derived from an earlier ethos wherein humanistic and scientific values occupied a shared culture. While the synthetic style of The Principles has hindered its readership, this article concludes that there is value to recovering the notion that the humanities and social sciences can contribute to the improvement of animal research. (shrink)

This article addresses the embodied nature of laboratory human—animal practices in order to understand the notions of care that take place within an institution of domination — the apparatus of animal experimentation. How is it possible to both love and harm in this context? Building on animal studies and feminist ethics, the theme of emotionality is explored in the section ‘loving animals’. Here it is demonstrated that empathy and affection for individual animals, as well as species, are strong components of (...) an experimental ethos expressed by the informants. The second empirical section deals with the issue of ‘killing well’. The good kill is supposed to be done with care: quickly and compassionately. This is performed by way of bodily measures of care, technological refinement and personal skills and, sometimes, with the help of a division of labour. In the concluding section, the empirical findings are read through the framework, where the feminist theoretical analysis of love, dependency and care from an embodiment perspective understands the dialectics of instrumentalisation and exploitation of — and care for — animals, not as something that goes on above or outside of relations, but rather as something that can be understood from within. ‘Mortal love’ is the attempt to capture and theorise this dialectic, arguing that emotions of love and friendship are not mere justifications for the harm and killing performed, but rather intrinsic dimensions of the embodied animaling of experimental human—animal relations. (shrink)

What is at the basis of moral action? An altruism acquired by the application of rule and principle? Or, as Noddings asserts, caring and the memory of being cared for? With numerous examples to supplement her rich theoretical discussion, Noddings builds a compelling philosophical argument for an ethics based on natural caring, as in the care of a mother for her child. The ethical behavior that grows out of natural caring, and has as its core care-filled receptivity to those involved (...) in any moral situation, leaves behind the rigidity of rule and principle to focus on what is particular and unique in human relations. Noddings's discussion is wide-ranging, as she considers whether organizations, which operate at a remove from the caring relationship, can truly be called ethical. She discusses the extent to which we may truly care for plants, animals, or ideas. Finally, she proposes a realignment of education to encourage and reward not just rationality and trained intelligence, but also enhanced sensitivity in moral matters. (shrink)

“When Species Meet is a breathtaking meditation on the intersection between humankind and dog, philosophy and science, and macro and micro cultures.” —Cameron Woo, Publisher of Bark magazine In 2006, about 69 million U.S. households had pets, giving homes to around 73.9 million dogs, 90.5 million cats, and 16.6 million birds, and spending over $38 billion dollars on companion animals. As never before in history, our pets are truly members of the family. But the notion of “companion species”—knotted from human (...) beings, animals and other organisms, landscapes, and technologies—includes much more than “companion animals.” In When Species Meet, Donna J. Haraway digs into this larger phenomenon to contemplate the interactions of humans with many kinds of critters, especially with those called domestic. At the heart of the book are her experiences in agility training with her dogs Cayenne and Roland, but Haraway’s vision here also encompasses wolves, chickens, cats, baboons, sheep, microorganisms, and whales wearing video cameras. From designer pets to lab animals to trained therapy dogs, she deftly explores philosophical, cultural, and biological aspects of animal-human encounters. In this deeply personal yet intellectually groundbreaking work, Haraway develops the idea of companion species, those who meet and break bread together but not without some indigestion. “A great deal is at stake in such meetings,” she writes, “and outcomes are not guaranteed. There is no assured happy or unhappy ending—socially, ecologically, or scientifically. There is only the chance for getting on together with some grace.” Ultimately, she finds that respect, curiosity, and knowledge spring from animal-human associations and work powerfully against ideas about human exceptionalism. One of the founders of the posthumanities, Donna J. Haraway is professor in the History of Consciousness Department at the University of California, Santa Cruz. Author of many books and widely read essays, including The Companion Species Manifesto: Dogs, People, and Significant Otherness and the now-classic essay “The Cyborg Manifesto,” she received the J. D. Bernal Prize in 2000, a lifetime achievement award from the Society for Social Studies in Science. (shrink)

ACKNOWLEDGMENTS. Among Those Who helped greatly in the initial stages of this project by making constructive suggestions on my first "caring" papers are Nick Burbules, William Doll, Bruce Fuller, Brian Hill, William Pinar, Mary Anne ...

This article explores the development of a novel biomedical research organism, and its potential to remake the species and spaces of translational medicine. The humanized mouse is a complex experimental object in which mice, rendered immunodeficient through genetic alteration, are engrafted with human stem cells in the hope of reconstituting a human immune system for biomedical research and drug testing. These chimeric organisms have yet to garner the same commentary from social scientists as other human–animal hybrid forms. Yet, they are (...) rapidly being positioned as central to translational medicine in immunological research and pharmaceutical development. This article explores the complex relations between species and spaces they seek to enact. Humanizing mice simultaneously moves these animal forms towards the intimate geographies of corporeal equivalence with humans and the expansive geographies of translational research. These multiple trajectories are achieved by the way humanized mice function as both uncertain ‘epistemic things’ and as expansive ‘collaborative things’, articulating mouse genetics with other research, notably stem cell science. In the context of post-genomics, their indeterminacy is critical to their collaborative value; their expansive potential follows as much from their biological openness as from specific expectations. Yet, these new research organisms have both accumulative and disruptive capacities, for there are patterns of interference between these trajectories, remaking boundaries between experimental practices and clinical contexts. (shrink)

Clever Hans, the famous horse who was believed to be able to count, is generally cited as the paradigm of the influence of the observer. Psychologist Rosenthal has illustrated this phenomenon with his well-known experiment about ‘bright’ and ‘dull’ maze rats. Hans, however, achieved something much more interesting. Hecould not only read human minds through their bodies: he could also influence his questioners to produce gestures he could read as cues for finding the answer. Hans could make human bodies be (...) moved and be affected, and move and affect other beings and perform things without their owners’ knowledge. The question of ‘influence’ when we read this case becomes therefore far more complicated and interesting. It involves the question of the way bodies can attune, affect and transformeach other. We may follow carefully how scientists of ethological practices create access to the creatures they study, how they are moved by their subjects of interest, and how they give them a chance to be interesting andto articulate other responses. Doing so, we notice that the signs that define subject and object, what talks and what is talked about, subjectivity and objectivity, are redistributed in a new manner. These practices offer a new and pragmatic definition of the body, close to James’s theory of emotions: to have a body is to learn how to feel. (shrink)

Since the early 1980s, actor-network theory has contested the status of “context” as an explanatory resource. Expressions and concepts such as “transformations of social worlds,” “enactments,” and “ontological politics” provide resources for grasping the ways in which agents actively transform the world and add something new. This has been of immense importance and serves as a warning against reducing events and actors to a given context. But a side effect of this forward looking move is that not enough attention is (...) given to that which enables issues and situations to emerge in the first place. Moreover, the focus on that which is constantly being enacted seems to have privileged the contemporary as the object of study and ethnography as the method of inquiry. History and the study of texts—from the past—seem, increasingly, to get lost in Science and Technology Studies. The aim of this article is instead to use actor-network theory resources as a historicizing method. The article explores the tense concern for the animal in political debates at the turn of the twentieth century. The article argues that contexts should not be seen as something external, but rather integral to the relevant text and situation, thus the very issue at stake. (shrink)

The biomedical industry relies on the skills of animal technologists to put laboratory animal welfare into practice. This is the first study to explore how this is achieved in relation to their participation in implementing refinement and reduction, two of the three key guiding ethical principles––the “3Rs”––of what is deemed to be humane animal experimentation. The interpretative approach contributes to emerging work within the social sciences and humanities exploring care and ethics in practice. Based on qualitative analysis of participant observation (...) within animal research facilities in UK universities, in-depth interviews with ATs, facility managers, and other stakeholders, and analysis of regulatory guidelines, we draw a contrast between the minimum required of ATs by law and how their care work not only meets but often exceeds these requirements. We outline how ATs constitute a key source of innovation and insight into the refinement of animal care and the reduction of animal use, hitherto not formally acknowledged. Exploring AT care work as an example of ethics in practice makes an original contribution to broader debates within health care and animal welfare about how technology, regulation, and behavior can foster and sustain a “culture of care”. (shrink)