In this case study from litigation, we show how ghostwriting of clinical trial results can contribute to the manipulation of data to favor the study medication. Study 329 for paroxetine pediatric use was negative for efficacy and positive for harm. Yet the ghostwritten publication from this study concluded that paroxetine provided evidence of efficacy and safety and continues to be influential. Despite the role of named authors in revisions of the manuscript, the sponsor company remained in control of the message.

There are these two absolutely basic problems: to learn about the universe and ourselves as a part of the universe, and to learn how to create a civilized world. Essentially, we have solved the first problem. We solved it when we created modern science. That is not to say that we know everything that is to be known, but we created a method for improving our knowledge about the world. But we haven't solved the second problem. And to solve the (...) first problem without solving the second problem is very, very dangerous. The crisis is this: the crisis of having science without civlization. (shrink)