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  1. Challenge studies of human volunteers: ethical issues.T. Hope - 2004 - Journal of Medical Ethics 30 (1):110-116.
    There is a long history of medical research that involves intentionally infecting healthy people in order to study diseases and their treatments. Such research—what might be called “human challenge studies”—are an important strand of much current research—for example, in the development of vaccinations. The many international and national guidelines about the proper conduct of medical research do not specifically address human challenge studies. In this paper we review the guidelines on the risk of harm that healthy volunteers may be exposed (...)
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  • Abortion policies at the bedside: incorporating an ethical framework in the analysis and development of abortion legislation.Alicia E. Hersey, Jai-Me Potter-Rutledge & Benjamin P. Brown - 2024 - Journal of Medical Ethics 50 (1):2-5.
    About 6% of women in the world live in countries that ban all abortions, and 34% in countries that only allow abortion to preserve maternal life or health. In the USA, over the last decades—even before Dobbs v. Jackson Women’s Health Organization overturned the federal right to abortion—various states have sought to restrict abortion access. Often times, this legislation has been advanced based on legislators’ personal moral values. At the bedside, in contrast, provision of abortion care should adhere to the (...)
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  • SARS-CoV-2 challenge studies: ethics and risk minimisation.Susan Bull, Euzebiusz Jamrozik, Ariella Binik & Michael J. Parker - 2021 - Journal of Medical Ethics 47 (12):e79-e79.
    COVID-19 poses an exceptional threat to global public health and well-being. Recognition of the need to develop effective vaccines at unprecedented speed has led to calls to accelerate research pathways ethically, including by conducting challenge studies ) with SARS-CoV-2. Such research is controversial, with concerns being raised about the social, legal, ethical and clinical implications of infecting healthy volunteers with SARS-CoV-2 for research purposes. Systematic risk evaluations are critical to inform assessments of the ethics of any proposed SARS-CoV-2 CHIs. Such (...)
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  • In critique of moral resilience: UK healthcare professionals’ experiences working with asylum applicants housed in contingency accommodation during the COVID-19 pandemic.Louise Tomkow, Gabrielle Prager, Kitty Worthing & Rebecca Farrington - 2024 - Journal of Medical Ethics 50 (1):33-38.
    This research explores the experiences of UK NHS healthcare professionals working with asylum applicants housed in contingency accommodation during the COVID-19 pandemic. Using a critical understanding of the concept of moral resilience as a theoretical framework, we explore how the difficult circumstances in which they worked were navigated, and the extent to which moral suffering led to moral transformation. Ten staff from a general practice participated in semistructured interviews. Encountering the harms endured by people seeking asylum prior to arrival in (...)
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  • Rationing, racism and justice: advancing the debate around ‘colourblind’ COVID-19 ventilator allocation.Harald Schmidt, Dorothy E. Roberts & Nwamaka D. Eneanya - 2022 - Journal of Medical Ethics 48 (2):126-130.
    Withholding or withdrawing life-saving ventilators can become necessary when resources are insufficient. In the USA, such rationing has unique social justice dimensions. Structural elements of dominant allocation frameworks simultaneously advantage white communities, and disadvantage Black communities—who already experience a disproportionate burden of COVID-19-related job losses, hospitalisations and mortality. Using the example of New Jersey’s Crisis Standard of Care policy, we describe how dominant rationing guidance compounds for many Black patients prior unfair structural disadvantage, chiefly due to the way creatinine and (...)
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