In feminist and cultural studies, there is a growing body of work concerned with how people’s lives are subjected to multiple, intersecting axes of differentiation and power. There is growing concern that we seem unable to address more than one difference at a time, thus failing to interrogate enactments of class, race, ethnicity, gender, and sexuality in science, technology, and medicine. This article aims to contribute to the effort to conceptualize the making of and interactions between differences. It explores how (...) differences such as disability, gender, and class are made and unmade in sociotechnical practices. It shows that interactions between enactments of differences are complex, contradictory, unpredictable, and surprising and defy simple conclusions about effects and politics. These patterns of interference need to be investigated in situated practices, and we have to examine carefully how processes of differentiation interact to support and reinforce but also to challenge and undermine each other. (shrink)