The biological sciences have become increasingly reliant on so-called ‘model organisms’. I argue that in this domain, the concept of a descriptive model is essential for understanding scientific practice. Using a case study, I show how such a model was formulated in a preexplanatory context for subsequent use as a prototype from which explanations ultimately may be generated both within the immediate domain of the original model and in additional, related domains. To develop this concept of a descriptive model, I (...) focus on use of the nematode worm Caenorhabditis elegans and the wiring diagrams that were developed as models of its neural structure. In addition, implications of the concept of a descriptive model, particularly its relevance for the data-phenomena distinction as well as its relation to long-standing debates on realism, are briefly examined. (shrink)

This paper aims to identify the key characteristics of model organisms that make them a specific type of model within the contemporary life sciences: in particular, we argue that the term “model organism” does not apply to all organisms used for the purposes of experimental research. We explore the differences between experimental and model organisms in terms of their material and epistemic features, and argue that it is essential to distinguish between their representational scope and representational target. We also examine (...) the characteristics of the communities who use these two types of models, including their research goals, disciplinary affiliations, and preferred practices to show how these have contributed to the conceptualization of a model organism. We conclude that model organisms are a specific subgroup of organisms that have been standardized to fit an integrative and comparative mode of research, and that it must be clearly distinguished from the broader class of experimental organisms. In addition, we argue that model organisms are the key components of a unique and distinctively biological way of doing research using models.Keywords: Experimental organism; Genetics; Model organism; Modeling; Philosophy of biology; Representation. (shrink)

In America by the 1930s, albino rats had become a kind of generic standard in research on physiology and behavior that de-emphasized diversity across species. However, prior to about 1915, the early work of many of the pioneer rat researchers in America and in central Europe reflected a strong interest in species differences and a deep regard for diversity. These scientists sought broad, often medical, generality, but their quest for generality using a standard animal did not entail a de-emphasis of (...) organic diversity. They chose white rats as test animals for two primary reasons. First, rats develop very slowly. They therefore made features of physiological, neural and psychological development accessible to the experimental method at a time when its application to the phenomena of development remained controversial. Secondly, rats were thought to have unusually strong sex drives. For this reason they became central to the experimental study of sexuality and, in the work of the reproductive physiologist Eugen Steinach, sexual development. Connections among three research institutes that stressed experimental approaches to the study of brain and development demonstrate the importance of the rat's institutional role. As the emphasis on experimentation in the study of development grew, two of these institutes bred rats to provide uniform materials. Eventually, however, their reasons for selecting rats were lost; and the ready availability of a uniform test animal led to a shift in scientists' presumptions about diversity, as the standard rat became a tool for assuring generality. (shrink)

This essay argues that shifts in patronage for the postwar behavioral and social sciences were linked intimately to both intellectual and institutional changes. This broad argument comprises two subarguments: first, that there were in fact two distinct, successive patronage systems for postwar social science—not one, as is commonly assumed; and, second, that the first postwar patronage system played a major role in enabling a series of behavioral revolutions and interdisciplinary syntheses across the social sciences, while the second postwar patronage system (...) encouraged the development of specialized concepts, techniques, and technologies within the disciplines. The essay also suggests that the widespread concern among social scientists in the 1970s and 1980s that their fields were fragmenting was at least in part an unintended consequence of the rise of the second system. (shrink)

In summary, the creation and maintenance of the Wistar Rats as standardized animals can be attributed to the breeding work of Helen Dean King, coupled with the management and husbandry methods of Milton Greenman and Louise Duhring, and with supporting documentation provided by Henry Donaldson. The widespread use of the Wistar Rats, however, is a function of the ingenuity of Milton Greenman who saw in them a way for a small institution to provide service to science. Greenman's rhetoric, as captured (...) in his Director's Reports, prepared annually from 1905 until his death in 1937, shows that he was unusually sensitive to his times and to the economics of science and of society. In the era when biology was being defined, he recognized in the rat the potential to be a living analog to the pure chemicals that legitimated experimental science. From management literature he extracted the ideals of uniformity of product, standards of quality, and efficiency of production, applying them to scientific practice to generate an animal model that thrives as standard equipment in laboratories throughout the world today.I will close with a quote from Frederick W. Taylor that is a cogent statement of the contribution to science and scientific progress made by standardized tools and their creators. Equating the surgeon and the workman, Taylor wrote: [He is given] the finest implements, each one of which has been the subject of special study and development ... [and] the very best knowledge of his predecessors; and, provided with standard implements and methods which represent the best knowledge of the world up to date, he is able to use his own originality and ingenuity to make real additions to the world's knowledge, instead of reinventing things which are old.Standardized tools, whether surgeons' implements or laboratory-bred rats, are one of the vehicles for carrying scientific knowledge forward from generation to generation. In this sense, Greenman's Wistar Rats have done their job, in his words, of “providing service to science.”. (shrink)

Even during its heyday, American behaviourist psychology was repeatedly criticized for the lack of diversity in its experimental subjects, with its almost exclusive focus on rats and pigeons. This paper revisits this debate by examining the rise and fall of a once promising alternative laboratory animal and model of intelligence, the raccoon. During the first two decades of the twentieth century, psychological investigations of the raccoon existed on the borderlands between laboratory experimentation, natural history and pet-keeping. Moreover, its chief advocate, (...) Lawrence W. Cole, inhabited the institutional and geographic borderlands of the discipline. This liminality ultimately worked against the raccoon's selection as a standardized model during the behaviourist era. The question of raccoon intelligence was also a prominent topic in the contemporaneous debates over the place of sentiment in popular nature writing. Although Cole and others argued that the raccoon provided unique opportunities to study mental attributes such as curiosity and attention, others accused the animal's advocates of sentimentalism, anthropomorphism and nature faking. The paper examines the making and unmaking of this hybrid scientific culture as the lives of experimenters and animals became entangled. (shrink)

This essay describes the approach and early results of the collaborative Embryo Project and its on-line encyclopedia. The project is based on a relational database that allows federated searches and inclusion of multiple types of objects targeted for multiple user groups. The emphasis is on the history and varied contexts of developmental biology, focusing on people, places, institutions, techniques, literature, images, and other aspects of study of embryos. This essay introduces the ways of working as well as the long-term goals (...) of the project. We invite others to join the effort, both in this particular project and in joining together in digital collection, archiving, and knowledge generation at the borders of biology and history. (shrink)

The biological sciences have become increasingly reliant on so-called 'model organisms'. I argue that in this domain, the concept of a descriptive model is essential for understanding scientific practice. Using a case study, I show how such a model was formulated in a preexplanatory context for subsequent use as a prototype from which explanations ultimately may be generated both within the immediate domain of the original model and in additional, related domains. To develop this concept of a descriptive model, I (...) focus on use of the nematode worm Caenorhabditis elegans and the wiring diagrams that were developed as models of its neural structure. In addition, implications of the concept of a descriptive model, particularly its relevance for the data-phenomena distinction as well as its relation to long-standing debates on realism, are briefly examined. (shrink)

Many of the recent advances in the history of science have come from local microstudies, but with the unintended by‐product of a typically “postmodern” fragmentation of knowledge. The question for us post‐postmodernists is how to write a broader “general” history of science—a history for all of us specialists—without losing the advantages of case study. One way, this essay suggests, is to structure case studies around the activities or issues that are common to knowledge production generally: for example, issues of common (...) practices, role and identity, credibility and trust, fairness in participation and reward, and translocal circulation. Such studies would be particular and local yet transcend the singularities of period, place, and discipline. They would facilitate productive contest over the general meaning of science in its diversely varied forms. (shrink)

Robert Yerkes is a pivotal figure in American psychology and primatology in the first half of the twentieth century. As is well known, Yerkes first studied ape intelligence in 1915, on a visit to the private California laboratory of the psychiatrist Gilbert Hamilton, a former student. Less widely appreciated is how far the work done at the Hamilton lab, in its aims and ambitions as well as its techniques, served as a template for much of Yerkes’s research thereafter. This paper (...) uses the Hamilton–Yerkes relationship to re-examine Yerkes’s career and, more generally, that of American psychology in the early twentieth century. Three points especially are emphasized: first, the role of Freudian psychoanalysis as a spur to Hamilton’s experimental studies of ape intelligence; second, the importance of Hamilton’s laboratory, with its semi-wild population of monkeys and ape, as a model for Yerkes’s efforts to create a laboratory of his own; and third, the influence on Yerkes of Hamilton’s optimism about experimental psychological studies of nonhuman primates as a source of lessons beneficial to a troubled human world. (shrink)

Where is America in the republic of letters? This question has formed in my mind over the last four years as I have collaborated on a new project based at Stanford University called Mapping the Republic of Letters. The project aims to enrich our understanding of the intellectual networks of major and minor figures in the republic of letters, the international world of learning that spanned the centuries roughly from 1400 to 1800. By creating visual images based on large digitized (...) data sets, we hope to reveal the hidden structures and conditions that nourished the growth of the republic of letters in the early modern era and the causes of its transformation in the nineteenth century. This task has only recently become feasible with the digitization of the correspondences of major intellectuals such as Benjamin Franklin, John Locke, Athanasius Kircher, and Voltaire, and of libraries, cabinets of artifacts, and Grand Tour itineraries. (shrink)

Behavioral science research in American universities was promoted and influenced by philanthropic foundations. In the 1920s and 1930s, Rockefeller philanthropies in particular financed behavioral science research projects that promised to fulfill their mandates to `improve mankind', mandates that foundation officers transformed into an informal, loosely defined human engineering effort. Controlling behavior, especially sexual and social `dysfunction', was a major priority. The behavioral scientists at Yale University, led by president James R. Angell and `psychobiologist' Robert M. Yerkes, tapped into foundation largesse (...) by crafting research programs that promised to contribute to the `welfare of mankind' through the investigation and control of sexual and social behavior. Foundation officers supported Yerkes' primate research because they accepted his premise that analyzing chimpanzee sexual behavior would yield valuable insights into the evolutionary underpinnings of human development and would thus give investigators the necessary information to ameliorate dysfunction. Between 1925 and 1940, philanthropic foundations contributed approximately $7 million to support the Yale Institute of Human Relations and the affiliated Yerkes Laboratories of Primate Biology. Yet, disappointment with the results of the Yale appropriations ultimately contributed to foundation officers turning away from behavioral sciences and toward biological sciences as they continued their efforts to improve mankind through human engineering. This article examines the interaction between foundation officers and Yale behavioral scientists to illustrate how scientific entrepreneurs successfully crafted rationales about human sexuality to solicit funds, how philanthropic foundation officers became enmeshed in the behavioral science research projects that they funded, and how a cooperative human engineering effort at Yale developed in the 1920s and unraveled in the 1930s. (shrink)

William Kirby and William Spence’s Introduction to Entomology is generally recognized as one of the founding texts of entomological science in English. This essay examines the ideological allegiances of the coauthors of the Introduction. In particular, it analyzes the ideological implications of their divergent opinions on animal instinct. Different vocational pursuits shaped each man’s natural history. Spence, a political economist, pursued fact‐based science that was shorn of references to religion. Kirby, a Tory High Churchman, placed revelation at the very heart (...) of his natural history. His strong commitment to partisan sectarianism cautions against reference to a homogeneous “natural theology” that was an agent of mediation. Fissures in the “common intellectual context” reached beyond the clash between natural theologians and radical anatomists to render the intellectual edifice of natural theology structurally less sound for the future. (shrink)

Computational methods and perspectives can transform the history of science by enabling the pursuit of novel types of questions, dramatically expanding the scale of analysis , and offering novel forms of publication that greatly enhance access and transparency. This essay presents a brief summary of a computational research system for the history of science, discussing its implications for research, education, and publication practices and its connections to the open-access movement and similar transformations in the natural and social sciences that emphasize (...) big data. It also argues that computational approaches help to reconnect the history of science to individual scientific disciplines. (shrink)