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  1. The historical foundations of the research-practice distinction in bioethics.Tom L. Beauchamp & Yashar Saghai - 2012 - Heoretical Medicine and Bioethics 33 (1):45-56.
    The distinction between clinical research and clinical practice directs how we partition medicine and biomedical science. Reasons for a sharp distinction date historically to the work of the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research, especially to its analysis of the “boundaries” between research and practice in the Belmont Report (1978). Belmont presents a segregation model of the research-practice distinction, according to which research and practice form conceptually exclusive sets of activities and interventions. This (...)
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  • Scientific research is a moral duty.J. Harris - 2005 - Journal of Medical Ethics 31 (4):242-248.
    Biomedical research is so important that there is a positive moral obligation to pursue it and to participate in itScience is under attack. In Europe, America, and Australasia in particular, scientists are objects of suspicion and are on the defensive.i“Frankenstein science”5–8 is a phrase never far from the lips of those who take exception to some aspect of science or indeed some supposed abuse by scientists. We should not, however, forget the powerful obligation there is to undertake, support, and participate (...)
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  • Unethical trials of interventions to reduce perinatal transmission of the human immunodeficiency virus in developing countries.Peter Lurie & Sidney M. Wolfe - 2011 - In Stephen Holland (ed.), Arguing About Bioethics. New York: Routledge. pp. 479.
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  • A Duty to Participate in Research: Does Social Context Matter?Inmaculada de Melo-Martín - 2008 - American Journal of Bioethics 8 (10):28-36.
    Because of the important benefits that biomedical research offers to humans, some have argued that people have a general moral obligation to participate in research. Although the defense of such a putative moral duty has raised controversy, few scholars, on either side of the debate, have attended to the social context in which research takes place and where such an obligation will be discharged. By reflecting on the social context in which a presumed duty to participate in research will obtain, (...)
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  • Placebo Orthodoxy in Clinical Research I: Empirical and Methodological Myths.Benjamin Freedman, Charles Weijer & Kathleen Cranley Glass - 1996 - Journal of Law, Medicine and Ethics 24 (3):243-251.
    The use of statistics in medical research has been compared to a religion: it has its high priests, supplicants, and orthodoxy. Although the comparison may be more unfair to religion than to research, a useful lesson can nonetheless be drawn: the practice of clinical research may benefit—as does the spirit—from critical self-examination. Arguably, no aspect of the conduct of clinical trials is currently more controversial—and thus in as dire need of critical examination—than the use of placebo controls. The ethical and (...)
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  • Clarifying the Concepts of Research Ethics.Robert J. Levine - 1979 - Hastings Center Report 9 (3):21-26.
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  • The Ethics of Using QI Methods to Improve Health Care Quality and Safety.Mary Ann Baily, Melissa Bottrell, Joanne Lynn & Bruce Jennings - 2006 - Hastings Center Report 36 (4):S1.
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  • Learning health systems, clinical equipoise and the ethics of response adaptive randomisation.Alex John London - 2018 - Journal of Medical Ethics 44 (6):409-415.
    To give substance to the rhetoric of ‘learning health systems’, a variety of novel trial designs are being explored to more seamlessly integrate research with medical practice, reduce study duration and reduce the number of participants allocated to ineffective interventions. Many of these designs rely on response adaptive randomisation. However, critics charge that RAR is unethical on the grounds that it violates the principle of equipoise. In this paper, I reconstruct critiques of RAR as holding that it is inconsistent with (...)
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  • Against the principle that the individual shall have priority over science.G. Helgesson & S. Eriksson - 2008 - Journal of Medical Ethics 34 (1):54-56.
    This paper highlights a feature common to many ethical guidelines—namely, the idea that the interests of the individual shall always prevail over the interests of science and society. The paper presents how some major ethical guidelines treat the balancing of research interests against those of research subjects and spells out the difficulties in interpreting the principle of the primacy of the individual in a way that can be action-guiding. It suggests various alternative interpretations of the primacy of the individual and (...)
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