In the 1940s and 1950s, nuclear magnetic resonance , one of the most important analytical techniques in chemistry, grew to maturity in the intermediate research field of chemical physics. Chemists and physicists adapted the new technology to the experimental culture of molecular spectroscopy which was based on a pragmatic experimental style. In molecular spectroscopy, the purpose of experiments was the establishment of methods that suited both the physicists' quest for precision and theoretical model building and the chemists' longing for empirical (...) data and understanding of structural formulae and reaction courses. In this process, an experimental style emerged that can be characterized as reliance on self‐built instrumentation, theoretical foundation in quantum mechanics, and proof of utility in the solution of structural and dynamical questions. This article focuses on the early development of NMR at Harvard University, with particular emphasis on the contributions of the first chemist working in the field of NMR, Herbert S. Gutowsky. (shrink)

From the 1950s to 1970s, physical techniques replaced many classical methods in the chemical and biological sciences. In this development, a novel type of method‐oriented scientists emerged, relying on cooperation with instrument manufacturers and forging close links with science‐funding agencies. Their main engagement was the development of methods and the improvement of instruments, responding to the needs of the chemical and biomedical communities. In the United States, an important institutional locus of such method‐oriented scientists were instrument centers, providing service to (...) regional and national groups of scientific users. This article analyzes the knowledge transfer involved in investigating the Biotechnology Resources Program of the National Institutes of Health, and presenting the example of one of these centers, the Stanford Magnetic Resonance Laboratory. (shrink)