Kants Metaphysische Anfangsgründe der Naturwissenschaft von 1786 stehen ihrem Anspruch nach zwischen einer transzendentalen Kritik der Vernunft - Kant bereitete zur selben Zeit die in wesentlichen Stücken umgearbeitete zweite Auflage der KrV vor - und der Physik als empirischer Wissenschaft. Die Notwendigkeit einer Reflexion über die Naturwissenschaft verhilft dieser Schrift heute wieder zu systematischer Relevanz, nachdem sie lange Zeit nur aus dem Blickwinkel ihrer Bedeutsamkeit für die empirische Naturwissenschaft betrachtet und infolgedessen allenfalls aus wissenschaftshistorischem Interesse rezipiert wurde.

In 1972, we proposed a theory of biological pattern formation in which concentration maxima of pattern forming substances are generated through local self- enhancement in conjunction with long range inhibition. Since then, much evidence in various developmental systems has confirmed the importance of autocatalytic feedback loops combined with inhibitory interaction. Examples are found in the formation of embryonal organizing regions, in segmentation, in the polarization of individual cells, and in gene activation. By computer simulations, we have shown that the theory (...) accounts for much of the regulatory phenomena observed, including signalling to regenerate removed parts. These self- regulatory features contribute to making development robust and error-tolerant. Furthermore, the resulting pattern is, to a large extent, independent of the details provided by initial conditions and inducing signals. (shrink)

What do biologists want? If, unlike their counterparts in physics, biologists are generally wary of a grand, overarching theory, at what kinds of explanation do biologists aim? A history of the diverse and changing nature of biological explanation in a particularly charged field, "Making Sense of Life" draws our attention to the temporal, disciplinary, and cultural components of what biologists mean, and what they understand, when they propose to explain life.