A historical and critical analysis of the concept of the gene that attempts to provide new perspectives and metaphors for the transformation of biology and its philosophy.

Summary In 1979, Robert C. Olby published an article titled ?Mendel no Mendelian??, in which he questioned commonly held views that Gregor Mendel (1822?1884) laid the foundations for modern genetics. According to Olby, and other historians of science who have since followed him, Mendel worked within the tradition of so-called hybridists, who were interested in the evolutionary role of hybrids rather than in laws of inheritance. We propose instead to view the hybridist tradition as an experimental programme characterized by a (...) dynamic development that inadvertently led to a focus on the inheritance of individual traits. Through a careful analysis of publications on hybridization by Carl Linnaeus (1707?1778), Joseph Gottlieb Koelreuter (1733?1806), Carl Friedrich Gärtner (1772?1850), and finally Mendel himself, we will show that this development consisted in repeated reclassifications of hybrids to accommodate anomalies, which in the end allowed Mendel to draw analogies between whole organisms, individual traits, and ?elements? contained in reproductive cells. Mendel's achievement was a product of normal science, and yet a revolutionary step forward. This also explains why, in 1900, when the report he gave on his experiments was ?rediscovered?, Mendel could be read as a ?Mendelian? (shrink)

This paper presents and discusses a series of hybridization experiments carried out by Nils Herman Nilsson-Ehle between 1900 and 1907 at a plant breeding station in Svalöf, Sweden. Since the late 1880s, the Svalöf station had been renowned for its ‘scientific’ breeding methods, which basically consisted of an elaborate system of record-keeping through which the offspring of individual plants were traced over generations while being meticulously described. This record system corresponded to a certain breeding technique and certain theoretical convictions . (...) Inspired by Tschermack’s translation of Mendel’s Pisum-paper, Nilsson-Ehle began his experiments in 1900 and published a first, major synthesis of his findings in 1908. If one compares these experiments as documented in the breeding records, with their representations in print, one encounters discrepancies in terms of procedure and presentation of data. This can be explained by the fact that Nilsson-Ehle was obliged to follow the recording and breeding procedures institutionalised at Svalöf, and these procedures, grounded in a taxonomic discourse, left little room for Mendelian hybridisation experiments. The twists and turns that this story takes are analysed in terms of Bachelardian philosophy of science, where the ‘epistemological obstacle’ functions as a central, analytic category. In contrast to Bachelard, however, I will characterise these obstacles as being of an institutional, rather than mental, nature. Thus characterized, moreover, they turn out to have been prerequisites as much as barriers to scientific progress. (shrink)

This book offers an integrated historical and philosophical examination of the origin of genetics. The author contends that an integrated HPS analysis helps us to have a better understanding of the history of genetics, and sheds light on some general issues in the philosophy of science. This book consists of three parts. It begins with historical problems, revisiting the significance of the work of Mendel, de Vries, and Weldon. Then it turns to integrated HPS problems, developing an exemplar-based analysis of (...) the development and the progress in early genetics. Finally, it discusses philosophical problems: conceptual change, evidence, and theory choice. Part I lays out a new historiography, serving as a basis for the discussions in part II and part III. Part II introduces a new integrated HPS method to analyse and interpret the historiography in Part I and to re-examine the philosophical issues in Part III. Part III develops new philosophical accounts which will in turn make a better sense of the history of scientific practice more generally. This book provides a practical defence of integrated HPS: the best way to defend integrated HPS is to do it. (shrink)

Alexander Bird indicates that the significance of Thomas Kuhn in the history of philosophy of science is somehow paradoxical. On the one hand, Kuhn was one of the most influential and important philosophers of science in the second half of the twentieth century. On the other hand, nowadays there is little distinctively Kuhn’s legacy in the sense that most of Kuhn’s work has no longer any philosophical significance. Bird argues that the explanation of the paradox of Kuhn’s legacy is that (...) Kuhn took a direction opposite to that of the mainstream of the philosophy of science in his later academic career. This paper aims to provide a new way to understand and develop Kuhn’s legacy by revisiting the development of Kuhn’s philosophy of science in 1970s and proposing a new account of exemplar. Firstly, I propose my diagnosis of Kuhn’s “wrong turning” by identifying Kuhn’s two novel contributions: the introduction of paradigm and the proposal of the incommensurability thesis. Secondly, I argue that Kuhn made a conceptual/terminological turn from paradigm to theory, which undermined Kuhn’s novel contributions. Thirdly, I propose a new articulation of exemplar and propose an exemplar-based approach to analysing the history of science. Finally, I show how the exemplar-based approach can be applied to analyse the history of science by my case study of the early development of genetics. (shrink)

Mendel's work in hybridization is ipso facto a study in inheritance. He is explicit in his interest to formulate universal generalizations, and at least in the case of the independent segregation of traits, he formulated his conclusions in the form of a law. Mendel did not discern, however, the inheritance of traits from that of the potential for traits. Choosing to study discrete non-overlapping traits, this did not hamper his efforts.

This paper aims to illustrate the influence of Franz Unger’s (1800–1870) and Carl Wilhelm Nägeli’s (1817–1891) anatomical and developmental works on Gregor Mendel’s (1822–1884) use of numerical ratios in biological inquiry. All hypotheses concerning Mendel’s sources of inspiration have hitherto overlooked the cytological teaching of Unger, his professor of botany. In the 1830s and 1840s, he was a pioneer of cell theory. His publications, including his university textbooks, are characterised by a particulate and quantifying approach towards vital phenomena. Special attention (...) will be paid to Unger’s and Nägeli’s ‘law of plant growth’, which shows some striking basic correspondences with Mendel’s approach. This demonstrates, firstly, that mathematical thinking was not alien to mid-nineteenth century botany, and secondly, that Mendel’s conceptions were influenced by an even greater variety of ideas circulating around 1850. (shrink)