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What Genes Can't Do

MIT Press (2003)

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  1. Is a Cognitive Revolution in Theoretical Biology Underway?Tiago Rama - 2024 - Foundations of Science 1:1-22.
    The foundations of biology have been a topic of debate for the past few decades. The traditional perspective of the Modern Synthesis, which portrays organisms as passive entities with limited role in evolutionary theory, is giving way to a new paradigm where organisms are recognized as active agents, actively shaping their own phenotypic traits for adaptive purposes. Within this context, this article raises the question of whether contemporary biological theory is undergoing a cognitive revolution. This inquiry can be approached in (...)
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  • Agential Teleosemantics.Tiago Rama - 2022 - Dissertation, Autonomous University of Barcelona
    The field of the philosophy of biology is flourishing in its aim to evaluate and rethink the view inherited from the previous century ---the Modern Synthesis. Different research areas and theories have come to the fore in the last decades in order to account for different biological phenomena that, in the first instance, fall beyond the explanatory scope of the Modern Synthesis. This thesis is anchored and motivated by this revolt in the philosophy of biology. -/- The central target in (...)
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  • What makes economics special: orientational paradigms.Paul Hoyningen-Huene & Harold Kincaid - 2023 - Journal of Economic Methodology (2):1-15.
    From the mid-1960s until the late 1980s, the well-known general philosophies of science of the time were applied to economics. The result was disappointing: none seemed to fit. This paper argues that this is due to a special feature of economics: it possesses ‘orientational paradigms’ in high number. Orientational paradigms are similar to Kuhn’s paradigms in that they are shared across scientific communities, but dissimilar to Kuhn’s paradigms in that they are not generally accepted as valid guidelines for further research. (...)
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  • The Origins of Species Concepts.John Simpson Wilkins - 2003 - Dissertation, University of Melbourne
    The longstanding species problem in biology has a history that suggests a solution, and that history is not the received history found in many texts written by biologists or philosophers. The notion of species as the division into subordinate groups of any generic predicate was the staple of logic from Aristotle through the middle ages until quite recently. However, the biological species concept during the same period was at first subtly and then overtly different. Unlike the logic sense, which relied (...)
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  • Mendel on Developmental Information.Yafeng Shan - 2021 - In Chris Meyns (ed.), Information and the History of Philosophy. Routledge. pp. 262-280.
    It has been widely received that one of Gregor Mendel’s most important contributions to the history of genetics is his novel work on developmental information (for example, the proposal of the famous Mendelian ratios like 1:2:1, 3:1, and 9:3:3:1). This view is well evidenced by the fact that much of early Mendelians’ work in the 1900s focuses on the retrodiction (viz. the re-analysis of the pre-exist data with Mendel’s approach). However, there is no consensus on what Mendel meant by development (...)
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  • Semiosis and Information: Meeting the Challenge of Information Science to Post-Reductionist Biosemiotics.Arran Gare - 2020 - Biosemiotics 13 (3):327-346.
    The concept of information and its relation to biosemiotics is a major area of contention among biosemioticians. Biosemioticians influenced by von Uexküll, Sebeok, Bateson and Peirce are critical of the way the concept as developed in information science has been applied to biology, while others believe that for biosemiotics to gain acceptance it will have to embrace information science and distance biosemiotics from Peirce’s philosophical work. Here I will defend the influence of Peirce on biosemiotics, arguing that information science and (...)
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  • How Biology Became Social and What It Means for Social Theory.Maurizio Meloni - 2014 - The Sociological Review 62:593-614.
    In this paper I first offer a systematic outline of a series of conceptual novelties in the life-sciences that have favoured, over the last three decades, the emergence of a more social view of biology. I focus in particular on three areas of investigation: (1) technical changes in evolutionary literature that have provoked a rethinking of the possibility of altruism, morality and prosocial behaviours in evolution; (2) changes in neuroscience, from an understanding of the brain as an isolated data processor (...)
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  • Thinking embodiment with genetics: epigenetics and postgenomic biology in embodied cognition and enactivism.Maurizio Meloni & Jack Reynolds - 2020 - Synthese 198 (11):10685-10708.
    The role of the body in cognition is acknowledged across a variety of disciplines, even if the precise nature and scope of that contribution remain contentious. As a result, most philosophers working on embodiment—e.g. those in embodied cognition, enactivism, and ‘4e’ cognition—interact with the life sciences as part of their interdisciplinary agenda. Despite this, a detailed engagement with emerging findings in epigenetics and post-genomic biology has been missing from proponents of this embodied turn. Surveying this research provides an opportunity to (...)
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  • Transhumanism, Moral Perfection, and Those 76 Trombones.Tom Koch - 2020 - Journal of Medicine and Philosophy 45 (2):179-192.
    Transhumanism advances an ideology promising a positive human advance through the application of new and as yet unrealized technologies. Underlying the whole is a libertarian ethos married to a very Christian eschatology promising a miraculous transformation that will answer human needs and redress human failings. In this paper, the supposedly scientific basis on which transhumanist promises are built is critiqued as futurist imaginings with little likelihood of actualization. Transhumanists themselves are likened to the affable con man Professor Harold Hill who, (...)
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  • Handbook of Evolutionary Thinking in the Sciences.Thomas Heams, Philippe Huneman, Guillaume Lecointre & Marc Silberstein (eds.) - 2014 - Springer.
    The Darwinian theory of evolution is itself evolving and this book presents the details of the core of modern Darwinism and its latest developmental directions. The authors present current scientific work addressing theoretical problems and challenges in four sections, beginning with the concepts of evolution theory, its processes of variation, heredity, selection, adaptation and function, and its patterns of character, species, descent and life. The second part of this book scrutinizes Darwinism in the philosophy of science and its usefulness in (...)
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  • Hybrid Deterministic Views About Genes in Biology Textbooks: A Key Problem in Genetics Teaching.Vanessa Carvalho dos Santos, Leyla Mariane Joaquim & Charbel Niño El-Hani - 2012 - Science & Education 21 (4):543-578.
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  • On the Biological Term “Gene” in the History of Science.Plischke Kurt & Labisch Alfons - 2017 - Endoxa 40:103.
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  • Essentialism, Vitalism, and the GMO Debate.Veronika Szántó - 2018 - Philosophy and Technology 31 (2):189-208.
    There has been a long-standing opposition to genetically modified organisms worldwide. Some studies have tried to identify the deep-lying philosophical, conceptual as well as psychological motivations for this opposition. Philosophical essentialism, psychological essentialism, and vitalism have been proposed as possible candidates. I approach the plausibility of the claim that these notions are related to GMO opposition from a historical perspective. Vitalism and philosophical essentialism have been associated with anti-GMO stance on account of their purported hostility to species and organismic mutability. (...)
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  • The issue of life: Aristotle in nursing perspective.Ingunn Elstad - 2009 - Nursing Philosophy 10 (4):275-286.
    This paper explores the issue of life and its relevance to nursing, through Aristotle's philosophy and an Aristotelian interpretation of Nightingale's Notes on Nursing. Life as process and becoming has ontological status in Aristotle's philosophy and this dynamism is particularly relevant for nursing. The paper presents aspects of Aristotle's philosophy of life: his account of life as inherent powers of the individual, his analysis of change and time, and his understanding of sickness and health as qualitative states of living beings. (...)
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  • Who is the mother? Negotiating identity in an Irish surrogacy case.Karin Christiansen - 2015 - Medicine, Health Care and Philosophy 18 (3):317-327.
    An Irish surrogacy case from 2013 illustrates how negotiations of the mother’s identity in a given national and legal context are drawing on novel scientific perspectives, at a time when the use of new biotechnological possibilities is becoming more widespread and commonplace. The Roman dictum, ‘Mater Semper Certa Est’ is contested by the finding of this Irish court, in which the judge made a declaration of parentage stating that the genetic parents of twins born using a surrogate were the parents. (...)
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  • The social brain meets the reactive genome: neuroscience, epigenetics and the new social biology.Maurizio Meloni - 2014 - Frontiers in Human Neuroscience 8.
    The rise of molecular epigenetics over the last few years promises to bring the discourse about the sociality and susceptibility to environmental influences of the brain to an entirely new level. Epigenetics deals with molecular mechanisms such as gene expression, which may embed in the organism “memories” of social experiences and environmental exposures. These changes in gene expression may be transmitted across generations without changes in the DNA sequence. Epigenetics is the most advanced example of the new postgenomic and context-dependent (...)
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  • The philosophical–anthropological foundations of Bennett and Hacker’s critique of neuroscience.Jasper van Buuren - 2015 - Continental Philosophy Review 49 (2):223-241.
    Bennett and Hacker criticize a number of neuroscientists and philosophers for attributing capacities which belong to the human being as a whole, like perceiving or deciding, to a “part” of the human being, viz. the brain. They call this type of mistake the “mereological fallacy”. Interestingly, the authors say that these capacities cannot be ascribed to the mind either. They reject not only materialistic monism but also Cartesian dualism, arguing that many predicates describing human life do not refer to physical (...)
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  • Objects and processes: two notions for understanding biological information.Agustín Mercado-Reyes, Pablo Padilla Longoria & Alfonso Arroyo-Santos - forthcoming - Journal of Theoretical Biology.
    In spite of being ubiquitous in life sciences, the concept of information is harshly criticized. Uses of the concept other than those derived from Shannon's theory are denounced as pernicious metaphors. We perform a computational experiment to explore whether Shannon's information is adequate to describe the uses of said concept in commonplace scientific practice. Our results show that semantic sequences do not have unique complexity values different from the value of meaningless sequences. This result suggests that quantitative theoretical frameworks do (...)
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  • (1 other version)Scientific Pluralism.Stephen H. Kellert, Helen E. Longino & C. Kenneth Waters (eds.) - 1956 - Univ of Minnesota Press.
    Scientific pluralism is an issue at the forefront of philosophy of science. This landmark work addresses the question, Can pluralism be advanced as a general, philosophical interpretation of science?
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  • International Handbook of Research in History, Philosophy and Science Teaching.Michael R. Matthews (ed.) - 2014 - Springer.
    This inaugural handbook documents the distinctive research field that utilizes history and philosophy in investigation of theoretical, curricular and pedagogical issues in the teaching of science and mathematics. It is contributed to by 130 researchers from 30 countries; it provides a logically structured, fully referenced guide to the ways in which science and mathematics education is, informed by the history and philosophy of these disciplines, as well as by the philosophy of education more generally. The first handbook to cover the (...)
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  • The Return of the Organism as a Fundamental Explanatory Concept in Biology.Daniel J. Nicholson - 2014 - Philosophy Compass 9 (5):347-359.
    Although it may seem like a truism to assert that biology is the science that studies organisms, during the second half of the twentieth century the organism category disappeared from biological theory. Over the past decade, however, biology has begun to witness the return of the organism as a fundamental explanatory concept. There are three major causes: (a) the realization that the Modern Synthesis does not provide a fully satisfactory understanding of evolution; (b) the growing awareness of the limits of (...)
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  • The somatic mutation theory of cancer: growing problems with the paradigm?Ana M. Soto & Carlos Sonnenschein - 2004 - Bioessays 26 (10):1097-1107.
    The somatic mutation theory has been the prevailing paradigm in cancer research for the last 50 years. Its premises are: (1) cancer is derived from a single somatic cell that has accumulated multiple DNA mutations, (2) the default state of cell proliferation in metazoa is quiescence, and (3) cancer is a disease of cell proliferation caused by mutations in genes that control proliferation and the cell cycle. From this compelling simplicity, an increasingly complicated picture has emerged as more than 100 (...)
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  • Proteins, the chaperone function and heredity.Valeria Mosini - 2013 - Biology and Philosophy 28 (1):53-74.
    In this paper I use a case study—the discovery of the chaperon function exerted by proteins in the various steps of the hereditary process—to re-discuss the question whether the nucleic acids are the sole repositories of relevant information as assumed in the information theory of heredity. The evidence I here present of a crucial role for molecular chaperones in the folding of nascent proteins, as well as in DNA duplication, RNA folding and gene control, suggests that the family of proteins (...)
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  • (1 other version)Understanding Contemporary Genomics.John Dupré - 2004 - Perspectives on Science 12 (3):320-338.
    Recent molecular biology has seen the development of genomics as a successor to traditional genetics. This paper offers an overview of the structure, epistemology, and history of contemporary genomics. A particular focus is on the question to what extent the genome contains, or is composed of, anything that corresponds to traditional conceptions of genes. It is concluded that the only interpretation of genes that has much contemporary scientific relevance is what is described as the "developmental defect" gene concept. However, developmental (...)
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  • (1 other version)Biological Atomism and Cell Theory.Daniel J. Nicholson - 2010 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 41 (3):202-211.
    Biological atomism postulates that all life is composed of elementary and indivisible vital units. The activity of a living organism is thus conceived as the result of the activities and interactions of its elementary constituents, each of which individually already exhibits all the attributes proper to life. This paper surveys some of the key episodes in the history of biological atomism, and situates cell theory within this tradition. The atomistic foundations of cell theory are subsequently dissected and discussed, together with (...)
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  • Ins and outs of systems biology vis-à-vis molecular biology: Continuation or clear cut?Philippe De Backer, Danny De Waele & Linda Van Speybroeck - 2009 - Acta Biotheoretica 58 (1):15-49.
    The comprehension of living organisms in all their complexity poses a major challenge to the biological sciences. Recently, systems biology has been proposed as a new candidate in the development of such a comprehension. The main objective of this paper is to address what systems biology is and how it is practised. To this end, the basic tools of a systems biological approach are explored and illustrated. In addition, it is questioned whether systems biology ‘revolutionizes’ molecular biology and ‘transcends’ its (...)
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  • Scientific Reasoning Is Material Inference: Combining Confirmation, Discovery, and Explanation.Ingo Brigandt - 2010 - International Studies in the Philosophy of Science 24 (1):31-43.
    Whereas an inference (deductive as well as inductive) is usually viewed as being valid in virtue of its argument form, the present paper argues that scientific reasoning is material inference, i.e., justified in virtue of its content. A material inference is licensed by the empirical content embodied in the concepts contained in the premises and conclusion. Understanding scientific reasoning as material inference has the advantage of combining different aspects of scientific reasoning, such as confirmation, discovery, and explanation. This approach explains (...)
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  • The Epistemic Goal of a Concept: Accounting for the Rationality of Semantic Change and Variation.Ingo Brigandt - 2010 - Synthese 177 (1):19-40.
    The discussion presents a framework of concepts that is intended to account for the rationality of semantic change and variation, suggesting that each scientific concept consists of three components of content: 1) reference, 2) inferential role, and 3) the epistemic goal pursued with the concept’s use. I argue that in the course of history a concept can change in any of these components, and that change in the concept’s inferential role and reference can be accounted for as being rational relative (...)
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  • What does it mean to be 75% pumpkin? The units of comparative genomics.Monika Piotrowska - 2009 - Philosophy of Science 76 (5):838-850.
    Comparative genomicists seem to be convinced that the unit of measurement employed in their studies is a gene that drives the function of cells and ultimately organisms. As a result, they have come to some substantive conclusions about how similar humans are to other organisms based on the percentage of genetic makeup they share. I argue that the actual unit of measurement employed in the studies corresponds to a structural rather than a functional gene concept, thus rendering many of the (...)
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  • The levels of selection debate: Philosophical issues.Samir Okasha - 2006 - Philosophy Compass 1 (1):74–85.
    For a number of years, the debate in evolutionary biology over the ’levels of selection’ has attracted intense interest from philosophers of science. The main question concerns the level of the biological hierarchy at which natural selection occurs. Does selection act on organisms, genes, groups, colonies, demes, species, or some combination of these? According to traditional Darwinian theory the answer is the organism -- it is the differential survival and reproduction of individual organisms that drives the evolutionary process. But there (...)
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  • The question of questions: What is a Gene? Comments on Rolston and Griffths & Stotz. [REVIEW]Lenny Moss - 2006 - Theoretical Medicine and Bioethics 27 (6):523-534.
    If the question ``What is a gene?'' proves to be worth asking it must be able to elicit an answer which both recognizes and address the reasons why the concept of the gene ever seemed to be something worth getting excited about in the first place as well analyzing and evaluating the latest develops in the molecular biology of DNA. Each of the preceding papers fails to do one of these and sufferrs the consequences. Where Rolston responds to the apparent (...)
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  • Taking development seriously: Who, what, when, where, why, how? [REVIEW]Alan C. Love - 2006 - Biology and Philosophy 21 (4):575-589.
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  • Molecular genetics.Ken Waters - 2008 - Stanford Encyclopedia of Philosophy.
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  • Rational animals: What the bravest lion won't risk.Ronald de Sousa - 2004 - Croatian Journal of Philosophy 4 (12):365-386.
    I begin with a rather unpromising dispute that Nozick once had with Ian Hacking in the pages of the London Review of Books, in which both vied with one another in their enthusiasm to repudiate the thesis that some human people or peoples are closer than others to animality. I shall attempt to show that one can build, on the basis of Nozick’s discussion of rationality, a defense of the view that the capacity tor language places human rationality out of (...)
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  • Life’s organization between matter and form: Neo-Aristotelian approaches and biosemiotics.Çağlar Karaca - 2021 - History and Philosophy of the Life Sciences 43 (2):1-40.
    In this paper, I discuss the neo-Aristotelian approaches, which usually reinterpret Aristotle’s ideas on form and/or borrow the notion of formal cause without engaging with the broader implications of Aristotle’s metaphysics. In opposition to these approaches, I claim that biosemiotics can propose an alternative view on life’s form. Specifically, I examine the proposals to replace the formal cause with gene-centrism, functionalism, and structuralism. After critically addressing these approaches, I discuss the problems of reconciling Aristotelianism with the modern view of life’s (...)
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  • (1 other version)Genetics without genes? The centrality of genetic markers in livestock genetics and genomics.James W. E. Lowe & Ann Bruce - 2019 - History and Philosophy of the Life Sciences 41 (4):1-29.
    In this paper, rather than focusing on genes as an organising concept around which historical considerations of theory and practice in genetics are elucidated, we place genetic markers at the heart of our analysis. This reflects their central role in the subject of our account, livestock genetics concerning the domesticated pig, Sus scrofa. We define a genetic marker as a element existing in different forms in the genome, that can be identified and mapped using a variety of quantitative, classical and (...)
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  • Properties of Life: Toward a Coherent Understanding of the Organism.Bernd Rosslenbroich - 2016 - Acta Biotheoretica 64 (3):277-307.
    The question of specific properties of life compared to nonliving things accompanied biology throughout its history. At times this question generated major controversies with largely diverging opinions. Basically, mechanistic thinkers, who tried to understand organismic functions in terms of nonliving machines, were opposed by those who tried to describe specific properties or even special forces being active within living entities. As this question included the human body, these controversies always have been of special relevance to our self-image and also touched (...)
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  • Philosophy of Molecular Biology.Ingo Brigandt - 2018 - eLS: Encyclopedia of Life Sciences.
    Ongoing empirical discoveries in molecular biology have generated novel conceptual challenges and perspectives. Philosophers of biology have reacted to these trends when investigating the practice of molecular biology and contributed to scientific debates on methodological and conceptual matters. This article reviews some major philosophical issues in molecular biology. First, philosophical accounts of mechanistic explanation yield a notion of explanation in the context of molecular biology that does not have to rely on laws of nature and comports well with molecular discovery. (...)
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  • Exploring Relationships Among Belief in Genetic Determinism, Genetics Knowledge, and Social Factors.Niklas Gericke, Rebecca Carver, Jérémy Castéra, Neima Alice Menezes Evangelista, Claire Coiffard Marre & Charbel N. El-Hani - 2017 - Science & Education 26 (10):1223-1259.
    Genetic determinism can be described as the attribution of the formation of traits to genes, where genes are ascribed more causal power than what scientific consensus suggests. Belief in genetic determinism is an educational problem because it contradicts scientific knowledge, and is a societal problem because it has the potential to foster intolerant attitudes such as racism and prejudice against sexual orientation. In this article, we begin by investigating the very nature of belief in genetic determinism. Then, we investigate whether (...)
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  • What kinds of kind are the senses?Brian L. Keeley - unknown
    In Western common sense, one speaks of there being five human senses, a claim apparently challenged by the biological and psychological sciences. Part of this challenge comes in the form of claiming the existence of additional senses. Part of the challenge comes from positing multiple senses where common sense only speaks of one, such as with the fractionation of “touch” into pressure and temperature senses. One conceptual difficulty in thinking about the number and division of senses is that it's not (...)
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  • The Heuristic of Form: Mitochondrial Morphology and the Explanation of Oxidative Phosphorylation.Karl S. Matlin - 2016 - Journal of the History of Biology 49 (1):37-94.
    In the 1950s and 1960s, the search for the mechanism of oxidative phosphorylation by biochemists paralleled the description of mitochondrial form by George Palade and Fritiof Sjöstrand using electron microscopy. This paper explores the extent to which biochemists studying oxidative phosphorylation took mitochondrial form into account in the formulation of hypotheses, design of experiments, and interpretation of results. By examining experimental approaches employed by the biochemists studying oxidative phosphorylation, and their interactions with Palade, I suggest that use of mitochondrial form (...)
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  • (1 other version)ESRC Centre for Genomics in Society University of Exeter.John Dupré - 2004 - Perspectives on Science 12 (3):320-338.
    . Recent molecular biology has seen the development of genomics as a successor to traditional genetics. This paper offers an overview of the structure, epistemology, and history of contemporary genomics. A particular focus is on the question to what extent the genome contains, or is composed of anything that corresponds to traditional conceptions of genes. It is concluded that the only interpretation of genes that has much contemporary scientific relevance is what is described as the “developmental defect” gene concept. However, (...)
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  • Where Does Pattee’s “How Does a Molecule Become a Message?” Belong in the History of Biosemiotics?Jon Umerez - 2009 - Biosemiotics 2 (3):269-290.
    Recalling the title of Yoxen’s classical paper on the influence of Schrödinger’s book, I analyze the role that the work of H. Pattee might have played, if any, in the development of Biosemiotics. I take his 1969 paper “How does a molecule become a message?” (Developmental Biology Supplement) as a first target due to several circumstances that make it especially salient. On the one hand, even if Pattee has obviously developed further his ideas on later papers, the significance of this (...)
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  • Environmental Ethics.Roberta L. Millstein - 2013 - In Kostas Kampourakis (ed.), The Philosophy of Biology: a Companion for Educators. Dordrecht: Springer.
    A number of areas of biology raise questions about what is of value in the natural environment and how we ought to behave towards it: conservation biology, environmental science, and ecology, to name a few. Based on my experience teaching students from these and similar majors, I argue that the field of environmental ethics has much to teach these students. They come to me with pent-up questions and a feeling that more is needed to fully engage in their subjects, and (...)
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  • Genetic Representation Explains the Cluster of Innateness‐Related Properties.Nicholas Shea - 2012 - Mind and Language 27 (4):466-493.
    The concept of innateness is used to make inferences between various better-understood properties, like developmental canalization, evolutionary adaptation, heritability, species-typicality, and so on (‘innateness-related properties’). This article uses a recently-developed account of the representational content carried by inheritance systems like the genome to explain why innateness-related properties cluster together, especially in non-human organisms. Although inferences between innateness-related properties are deductively invalid, and lead to false conclusions in many actual cases, where some aspect of a phenotypic trait develops in reliance on (...)
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  • Gene.Paul E. Griffiths & Karola Stotz - 2007 - In David L. Hull & Michael Ruse (eds.), The Cambridge Companion to the Philosophy of Biology. New York: Cambridge University Press.
    The historian Raphael Falk has described the gene as a ‘concept in tension’ (Falk 2000) – an idea pulled this way and that by the differing demands of different kinds of biological work. Several authors have suggested that in the light of contemporary molecular biology ‘gene’ is no more than a handy term which acquires a specific meaning only in a specific scientific context in which it occurs. Hence the best way to answer the question ‘what is a gene’, and (...)
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  • The past illuminates the present.Bruce H. Weber - 2006 - Biology and Philosophy 21 (2):287-298.
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  • Representation in the genome and in other inheritance systems.Nicholas Shea - 2007 - Biology and Philosophy 22 (3):313-331.
    There is ongoing controversy as to whether the genome is a representing system. Although it is widely recognised that DNA carries information, both correlating with and coding for various outcomes, neither of these implies that the genome has semantic properties like correctness or satisfaction conditions, In the Scope of Logic, Methodology, and the Philosophy of Sciences, Vol. II. Kluwer, Dordrecht, pp. 387–400). Here a modified version of teleosemantics is applied to the genome to show that it does indeed have semantic (...)
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  • When Traditional Essentialism Fails: Biological Natural Kinds.Robert A. Wilson, Matthew J. Barker & Ingo Brigandt - 2007 - Philosophical Topics 35 (1-2):189-215.
    Essentialism is widely regarded as a mistaken view of biological kinds, such as species. After recounting why (sections 2-3), we provide a brief survey of the chief responses to the “death of essentialism” in the philosophy of biology (section 4). We then develop one of these responses, the claim that biological kinds are homeostatic property clusters (sections 5-6) illustrating this view with several novel examples (section 7). Although this view was first expressed 20 years ago, and has received recent discussion (...)
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  • Genes in the postgenomic era.Paul E. Griffiths & Karola Stotz - 2006 - Theoretical Medicine and Bioethics 27 (6):499-521.
    We outline three very different concepts of the gene—instrumental, nominal, and postgenomic. The instrumental gene has a critical role in the construction and interpretation of experiments in which the relationship between genotype and phenotype is explored via hybridization between organisms or directly between nucleic acid molecules. It also plays an important theoretical role in the foundations of disciplines such as quantitative genetics and population genetics. The nominal gene is a critical practical tool, allowing stable communication between bioscientists in a wide (...)
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