This paper surveys a decade of philosophical discussion of laboratory science, and concludes with a bibliography. Among its topics are: (1) The historical emergence of distinct styles of experimental reasoning and practice; the relation of this to constructionalist theses. (2) The extension of Duhem's thesis to instruments and apparatus; not only are theory and observation malleable resources, but also the materiel with which one works. (3) The demarcation of science not by method or content, but by product; the creation of (...) phenomena. (4) The disunity of science; science conceived of as a motley of autonomous activities, not as hierarchy. (5) The need to rethink the idea of experiment as intervention; to replace the model of experimenter as master of nature by that of investigator as collaborator. (shrink)

This paper is devoted to an examination of the discovery, characterization, and analysis of the functions of microRNAs, which also serves as a vehicle for demonstrating the importance of exploratory experimentation in current (post-genomic) molecular biology. The material on microRNAs is important in its own right: it provides important insight into the extreme complexity of regulatory networks involving components made of DNA, RNA, and protein. These networks play a central role in regulating development of multicellular organisms and illustrate the importance (...) of epigenetic as well as genetic systems in evolution and development. The examination of these matters yields principled arguments for the historicity of the functions of key biological molecules and for the indispensability of exploratory experimentation in contemporary molecular biology as well as some insight into the complex interplay between exploratory experimentation and hypothesis-driven science. This latter result is not only important for philosophy of science, but also of practical importance for the evaluation of grant proposals, although the elaboration of this latter claim must be left for another occasion. (shrink)