A central problem facing a probabilistic approach to the problem of induction is the difficulty of sufficiently constraining prior probabilities so as to yield the conclusion that induction is cogent. The Principle of Indifference, according to which alternatives are equiprobable when one has no grounds for preferring one over another, represents one way of addressing this problem; however, the Principle faces the well-known problem that multiple interpretations of it are possible, leading to incompatible conclusions. I propose a partial solution to (...) the latter problem, drawing on the notion of explanatory priority. The resulting synthesis of Bayesian and inference-to-best-explanation approaches affords a principled defense of prior probability distributions that support induction. (shrink)