Hans Krebs' discovery, in 1932, of the urea cycle was a major event in biochemistry. This article describes a program, KEKADA, which models the heuristics Hans Krebs used in this discovery. KEKADA reacts to surprises, formulates explanations, and carries out experiments in the same manner as the evidence in the form of laboratory notebooks and interviews indicates Hans Krebs did. Furthermore, we answer a number of questions about the nature of the heuristics used by Krebs, in particular: How domain‐specific are (...) the heuristics? To what extent are they idiosyncratic to Krebs? To what extent do they represent general strategies of problem‐solving search?The relative generality of KEKADA allows us to view the control structure of KEKADA and its domain‐independent heuristics as a model of scientific experimentation that should apply over a broad domain. (shrink)

New computer systems of discovery create a research program for logic and philosophy of science. These systems consist of inference rules and control knowledge that guide the discovery process. Their paths of discovery are influenced by the available data and the discovery steps coincide with the justification of results. The discovery process can be described in terms of fundamental concepts of artificial intelligence such as heuristic search, and can also be interpreted in terms of logic. The traditional distinction that places (...) studies of scientific discovery outside the philosophy of science, in psychology, sociology, or history, is no longer valid in view of the existence of computer systems of discovery. It becomes both reasonable and attractive to study the schemes of discovery in the same way as the criteria of justification were studied: empirically as facts, and logically as norms. (shrink)

It is often claimed that there can be no such thing as a logic of scientific discovery, but only a logic of verification. By 'logic of discovery' is usually meant a normative theory of discovery processes. The claim that such a normative theory is impossible is shown to be incorrect; and two examples are provided of domains where formal processes of varying efficacy for discovering lawfulness can be constructed and compared. The analysis shows how one can treat operationally and formally (...) phenomena that have usually been dismissed with fuzzy labels like 'intuition' and 'creativity'. (shrink)

This article reviews the transition between post-Fregean anti-naturalistic epistemology and contemporary naturalistic epistemologies. It traces the revival of naturalism to Quine’s critique of the "a priori", and Kuhn’s defense of historicism, and use the arguments of Quine and Kuhn to identify a position, "traditional naturalism", that combines naturalistic themes with the claim that epistemology is a normative enterprise. Pleas for more radical versions of naturalism are articulated, and briefly confronted.

This paper analyzes and evaluates quine's influential thesis that epistemology should become a chapter of empirical psychology. quine's main point, it is argued, is that normativity must be banished from epistemology and, more generally, philosophy. i claim that without a normative concept of justification, we lose the very concept of knowledge, and that belief ascription itself becomes impossible without a normative concept of rationality. further, the supervenience of concepts of epistemic appraisal shows that normative epistemology is indeed possible.

Fourteen subjects were tape‐recorded while they undertook to find a law to summarize numerical data they were given. The source of the data was not identified, nor were the variables labeled semantically. Unknown to the subjects, the data were measurements of the distances of the planets from the sun and the periods of their revolutions about it—equivalent to the data used by Johannes Kepler to discover his third law of planetary motion.Four of the 14 subjects discovered the same law as (...) Kepler did (the period varies as the 3/2 power of the distance), and a fifth came very close to the answer. The subiects' protocols provide a detailed picture of the problem‐solving searches they engaged in, which were mainly, but not exclusively, in the space of possible functions for fitting the data, and provide explanations as to why some succeeded and the others failed.The search heuristics used by the subjects are similar to those embodied in the BACON program, computer simulation of certain scientific discovery processes. The experiment demonstrates the feasibility of examining some of the processes of scientific discovery by recreating, in the laboratory, discovery situations of substantial historical relevance. It demonstrates also, that under conditions rather similar to those of the original discoverer, a law can be rediscovered by persons of ordinary intelligence (i.e., the intelligence needed for academic success in a good university). The data for the successful subjects reveal no “creative” processes in this kind of a discovery situation different from those that are regularly observed in all kinds of problem‐solving settings. (shrink)