This ambitious book by one of the most original and provocative thinkers in science studies offers a sophisticated new understanding of the nature of scientific, mathematical, and engineering practice and the production of scientific knowledge. Andrew Pickering offers a new approach to the unpredictable nature of change in science, taking into account the extraordinary number of factors—social, technological, conceptual, and natural—that interact to affect the creation of scientific knowledge. In his view, machines, instruments, facts, theories, conceptual and mathematical structures, disciplined (...) practices, and human beings are in constantly shifting relationships with one another—"mangled" together in unforeseeable ways that are shaped by the contingencies of culture, time, and place. Situating material as well as human agency in their larger cultural context, Pickering uses case studies to show how this picture of the open, changeable nature of science advances a richer understanding of scientific work both past and present. Pickering examines in detail the building of the bubble chamber in particle physics, the search for the quark, the construction of the quarternion system in mathematics, and the introduction of computer-controlled machine tools in industry. He uses these examples to address the most basic elements of scientific practice—the development of experimental apparatus, the production of facts, the development of theory, and the interrelation of machines and social organization. (shrink)

The ArgumentIn the first part of this paper, issues concerning an “epistemology of time” are raised. The Derridean theme of the historial movement of a trace is connected to Prigogine's notion of an operator-time. It is suggested that both conceptions can be used to characterize the dynamics of experimental systems in contemporary science. It is argued that such systems have, to speak with Hacking, “a life of their own” and that this is precisely the reason for their inherent unpredictability.In the (...) second part, a case from the history of virology and cytomorphology is presented. The movement of a particular experimental system is followed in its peculiar tension between deferring and becoming different—i.e., between the persistence of a problem and the vagaries of its successive transformations. They are rendered possible by novel technical implementations, but they are not determined in any meaningful sense on a mere technological level.In conclusion, a point is made for a deconstructive approach to the history of science. (shrink)

The past twenty years have been an incredibly productive period in science studies. Still, because recent work in science studies puts a spotlight on agency and enabling situa tions, many practitioners in the field ignore, underplay, or dismiss the possibility that historically established, structurally stable attributes of the world may systemically shape practice at the laboratory level. This article questions this general position. Draw ing on data from a participant observation study of a university biology laboratory, it describes five features (...) of the institutional landscape that shape this laboratory's practice. (shrink)

The authors study how an aerosol technology research group constructed a research agenda for itself and how its activity was changed in the process. The group's research agenda was heterogeneous, comprising several research areas in which the knowledge of aerosols was applied in different industrial contexts. The authors analyze the development of one of these areas, the research on the production of ultrafine particles from 1992 to 1997, employing the concept of mediated activity that has been developed in the cultural-historical (...) theory of activity. In the analysis, the activity is seen as the coevolution of the subject, the means, and the research object and the networks of collaboration with other activities. The applications developed in the collaborative networks significantly influence the identity and learning of the researchers, the construction of tools and instruments, and the selection of the phenomena to be studied. (shrink)

A recurrent theme in ethnomethodological research is that of instructed actions. Contrary to the classic traditions in the social and cognitive sciences, which attribute logical priority or causal primacy to instructions, rules, and structures of action, ethnomethodologists investigate the situated production of actions which enable such formulations to stand as adequate accounts. Consequently, a recitation of formal structures can not count as an adequate sociological description, when no account is given of the local production ofwhat those structures describe. The natural (...) sciences can be described as a domain of practical action in whichthe use of methods enables the intersubjective reproduction of naturalistic observations and experiments. As numerous sociological studies of laboratory practices have shown, the achievement of intersubjective order cannot be reduced to formal methods; instead, it arises from the work of custom-fitting relevant methods to the local circumstances of the research. In this paper we discuss a possible extension of this idea to cover two intertwined aspects of molecular biology: (1) the work of following instructions on how to perform routine laboratory procedures, and (2) the relationship between cellular orders and the encoded instructions contained in the DNA molecule. We suggest that a classic conception of scientific action is implied by the way formal instructions are treated as a primary basis, both for molecular biologists' actions and the cellular functions they study, and we envision an ethnomethodological alternative to those conceptions of social and biological order. (shrink)

In 1991, the myotonic dystrophy gene was cloned by researchers from Cardiff, London, and elsewhere overseas. This article examines the relationships between the different research groups. It shows that the scientific collaboration on the myotonic dystrophy research was not a constant, stable feature of scientific progress but a process whereby the relationships among the scientists altered over time according to the stage of the research. This process was mediated by vested interests, by personalities, by the power differentials of the groups, (...) by the resources of the groups, by subcollaborations, and by interactions with those outside the main research network. The collaboration can be seen as a continuum, ranging from full cooperation with all parties to selected revelations to specific parties to intense competition. These cooperative and competitive relationships are seen primarily from the perspective of one research group, with whom intensive field research was conducted. (shrink)

The living world is one of complexity, the result of innumerable interactions among organisms, cells, molecules. In analyzing a problem, the biologist is constrained to focus on a fragment of reality, on a piece of the universe which he arbitrarily isolates to define certain of its parameters.In biology, any study thus begins with the choice of a “system.” On this choice depend the experimenter's freedom to maneuver, the nature of the questions he is free to ask, and even, often, the (...) type of answer he can obtain. (shrink)