The nature/nurture debate is not dead. Dichotomous views of development still underlie many fundamental debates in the biological and social sciences. Developmental systems theory offers a new conceptual framework with which to resolve such debates. DST views ontogeny as contingent cycles of interaction among a varied set of developmental resources, no one of which controls the process. These factors include DNA, cellular and organismic structure, and social and ecological interactions. DST has excited interest from a wide range of researchers, from (...) molecular biologists to anthropologists, because of its ability to integrate evolutionary theory and other disciplines without falling into traditional oppositions. The book provides historical background to DST, recent theoretical findings on the mechanisms of heredity, applications of the DST framework to behavioral development, implications of DST for the philosophy of biology, and critical reactions to DST. (shrink)

A historical and critical analysis of the concept of the gene that attempts to provide new perspectives and metaphors for the transformation of biology and its philosophy.

What do biologists want? If, unlike their counterparts in physics, biologists are generally wary of a grand, overarching theory, at what kinds of explanation do biologists aim? A history of the diverse and changing nature of biological explanation in a particularly charged field, "Making Sense of Life" draws our attention to the temporal, disciplinary, and cultural components of what biologists mean, and what they understand, when they propose to explain life.

Development and Evolution surveys and illuminates the key themes of rapidly changing fields and areas of controversy that the redefining the theory and philosophy of biology. It continues Stanley Salthe's investigation of evolutionary theory, begun in his influential book Evolving Hierarchical Systems, while negating the implicit philosophical mechanisms of much of that work. Here Salthe attempts to reinitiate a theory of biology from the perspective of development rather than from that of evolution, recognizing the applicability of general systems thinking to (...) biological and social phenomena and pointing towards a non-Darwinian and even a postmodern biology. (shrink)

Advances in molecular biological research in the latter half of the twentieth century have made the story of the gene vastly complicated: the more we learn about genes, the less sure we are of what a gene really is. Knowledge about the structure and functioning of genes abounds, but the gene has also become curiously intangible. This collection of essays renews the question: what are genes? Philosophers, historians and working scientists re-evaluate the question in this volume, treating the gene as (...) a focal point of interdisciplinary and international research. It will be of interest to professionals and students in the philosophy and history of science, genetics and molecular biology. (shrink)

Biosemiotics is the synthesis of biology and semiotics, and its main purpose is to show that semiosis is a fundamental component of life, i.e., that signs and meaning exist in all living systems. This idea started circulating in the 1960s and was proposed independently from enquires taking place at both ends of the Scala Naturae. At the molecular end it was expressed by Howard Pattee’s analysis of the genetic code, whereas at the human end it took the form of Thomas (...) Sebeok’s investigation into the biological roots of culture. Other proposals appeared in the years that followed and gave origin to different theoretical frameworks, or different schools, of biosemiotics. They are: (1) the physical biosemiotics of Howard Pattee and its extension in Darwinian biosemiotics by Howard Pattee and by Terrence Deacon, (2) the zoosemiotics proposed by Thomas Sebeok and its extension in sign biosemiotics developed by Thomas Sebeok and by Jesper Hoffmeyer, (3) the code biosemiotics of Marcello Barbieri and (4) the hermeneutic biosemiotics of Anton Markoš. The differences that exist between the schools are a consequence of their different models of semiosis, but that is only the tip of the iceberg. In reality they go much deeper and concern the very nature of the new discipline. Is biosemiotics only a new way of looking at the known facts of biology or does it predict new facts? Does biosemiotics consist of testable hypotheses? Does it add anything to the history of life and to our understanding of evolution? These are the major issues of the young discipline, and the purpose of the present paper is to illustrate them by describing the origin and the historical development of its main schools. (shrink)

The development of form in living organisms continues to challenge biological research. The concept of biological information encoded in the genetic program that controls development forms a major part of the semiotic metaphor in biology. Development is here seen in analogy to an execution of a program, written in a formal language in the computer. Other versions of the semiotic or "nature-as-language" metaphor use other formal or informal aspects of language to comprehend the specific structural relations in nature as explored (...) by molecular and evolutionary biology. This intuitively appealing complex of related ideas, which has a long history in the philosophy of nature and biology, is critically reviewed. The general nature of metaphor in science is considered, and different levels of metaphorical transfer of signification is distinguished. It is argued, that the metaphors may be of considerable value, not only heuristically, but in order to comprehend the irreducible nature of living organisms. In arguing for a semiotic perspective on living nature, it makes a marked difference whether the departure is made from the tradition of F. de Saussure´s structural linguistics or from the tradition of general semiotics of C. S. Peirce. An agenda is made for a Peircean perspective on the semiotics of nature. (shrink)

It is argued, that theory sf signs, especially in the tradition of the great philosopher Charles Sanders Peirce (1839–1914) can inspire the study of central problems in the philosophy of biology. Three such problems are considered: (1) The nature of biology as a science, where a semiotically informed pluralistic approach to the theory of science is introduced. (2) The peculiarity of the general object of biology, where a realistic interpretation of sign- and information-concepts is required to see sign-processes as immanent (...) in nature. (3) The possibility of an artificial construction of life, hereby discussed as a conceptual problem in the present form of the artificial life project and its implied definition of life. (shrink)

All sciences have epistemic assumptions, a language for expressing their theories or models, and symbols that reference observables that can be measured. In most sciences the language in which their models are expressed are not the focus of their attention, although the choice of language is often crucial for the model. On the contrary, biosemiotics, by definition, cannot escape focusing on the symbol–matter relationship. Symbol systems first controlled material construction at the origin of life. At this molecular level it is (...) only in the context of open-ended evolvability that symbol–matter systems and their functions can be objectively defined. Symbols are energy-degenerate structures not determined by laws that act locally as special boundary conditions or constraints on law-based energy-dependent matter in living systems. While this partial description holds for all symbol systems, cultural languages are much too complex to be adequately described only at the molecular level. Genetic language and cultural languages have common basic requirements, but there are many significant differences in their structures and functions. (shrink)

This book is a collection of papers which reflect the recent trends in the philosophy and history of molecular biology. It brings together historians, philosophers, and molecular biologists who reflect on the discipline's emergence in the 1950's, its explosive growth, and the directions in which it is going. Questions addressed include: (i) what are the limits of molecular biology? (ii) What is the relation of molecular biology to older subdisciplines of biology, especially biochemistry? (iii) Are there theories in molecular biology? (...) (iv) If so, how are these theories structured? (v) What role did information theory play in the rise of molecular biology? The book will open the way for many future researchers. (shrink)

In this paper we review and argue for the relevance of the concept of open-ended evolution in biological theory. Defining it as a process in which a set of chemical systems bring about an unlimited variety of equivalent systems that are not subject to any pre-determined upper bound of organizational complexity, we explain why only a special type of self-constructing, autonomous systems can actually implement it. We further argue that this capacity derives from the ‘dynamic decoupling’ (in its minimal or (...) most basic sense: the phenotype–genotype decoupling) by means of which a radically new way of material organization (minimal living organization) is achieved, allowing for the long-term sustenance of systems whose individual-metabolic and collective-historical pathways become thereafter deeply intertwined. (shrink)

ABSTRACT. This paper contemplates Organicism and its relation with molecular and evolutionary biology. We explore whether twentieth-first century biology is returning to positions held at the beginning of the twentieth century and then abandoned. The guiding line is a history of theoretical biology in which we distinguish three periods: 1. The 20s-30s, and the Theoretical Biology Club (Needham, Woodger, and Waddington, among others); 2. An intermediate period in the 60s-70s, in which, in spite of the eclosion of the molecular and (...) evolutionary biologies, there is some recovery of organicist positions, and 3. The present post-genomic situation, which is demanding a systemic approach. (shrink)

The general concept of information does not belong in the category of universal and inexorable physical laws but in the category of initial conditions and boundary conditions. Boundary conditions formed by local structures are often called constraints. Informational structures such as symbol vehicles are a special type of constraint. It should be clear that the concepts of initial conditions and constraints in physics make no sense outside the context of the law-based physical dynamics to which they apply. This is also (...) the case for the concept of information. -/- . (shrink)

This dissertation examines the functional roles symbols play in biological organisms, scientific models and adaptive learning devices, analyzing the process of how symbols acquire new functions. The semiotic categories of syntactics, semantics, and pragmatics are used to examine the functioning of symbols in organisms, models, and devices. The dissertation explores how we would go about designing self-organizing devices which adaptively construct their own relationships to the physical world . It bears on the frame/feature-generation problem in artificial intelligence, the problem of (...) machine creativity in philosophy, the measurement problem in physics, the problem of generating new observables in science, and the problem of emergent functions in evolutionary biology. Much of the perspective comes out of the work of theoretical biologists Howard Pattee and Robert Rosen. ;An analytical framework is developed for distinguishing between computation, measurement, control, and nonsymbolic functionalities. A taxonomy of adaptive cybernetic devices is proposed in which nonadaptive devices are distinguished from computationally adaptive ones and semantically adaptive ones . Evolutionary devices adaptively construct their own sensors and effectors contingent upon their performance, and are thus qualitatively different from devices now in use. Evolutionary devices are analogous to the biological evolution of new sense and effector organs. Relative capacities and limitations of the device types are outlined. ;Three contemporary conceptions of emergence are distinguished: computational emergence, thermodynamic emergence, and emergence-relative-to-a-model. Levels of adaptivity are connected to types of emergence. ;Throughout, purely computational, logic-driven strategies for generating new functions are criticized as being incapable of generating new primitives. It is argued that computers have completely nonemergent behavior because of their completely specified, digital, symbolic nature, while biological organisms are capable of emergent behavior because they also include analog, nonsymbolic processes. An evolutionary robotics research program is suggested as an alternative to purely computational approaches. (shrink)

In the first comprehensive biography of Erwin Schrödinger--a brilliant and charming Austrian, a great scientist, and a man with a passionate interest in people and ideas--the author draws upon recollections of Schrödinger's friends, family and colleagues, and on contemporary records, letters and diaries. Schrödinger led a very intense life, both in his research and in the personal realm. This book portrays his life against the backdrop of Europe at a time of change and unrest. His best known scientific work was (...) the discovery of wave mechanics, for which he was awarded the Nobel Prize in 1933. In Dublin, he wrote his most famous and influential book What is Life?, which attracted some of the brightest minds of his generation into molecular biology. This highly readable biography of a fascinating and complex man will appeal to anyone interested in the history of our times, and in the life and thought of one of the great men of twentieth-century science. (shrink)

Drawing on tools from rhetoric and poststructuralist theory, the author argues that the ascent of molecular biology, with its emphasis on molecules such as DNA rather than organisms, was enabled by crucial rhetorical “softwares.”.