Interdisciplinary research has been a popular idea with many people in the last 20 years. Academic administrators have admonished their faculty to become more interdisciplinary. Students often request the chance to pursue an interdisciplinary degree. While the issue of managing interdisciplinary projects has received a fair amount of attention by those interested in science management, interdisciplinary research has received little attention from historians, philosophers or sociologists of science or from scientists themselves. Yet, there l;lre a number of cases within the (...) life sciences where researchers have been actively engaged in endeavors that take them across disciplinary boundaries. These are ripe for investigation by those interested in the process of science. To provide an in-depth study of some historical or contemporary cases of cross disciplinary research activity in the life sciences, a conference was held at Georgia State University in May, 1984. This conference was supported by the National Endowment for the Humanities (U. S. A. ) through their research conference program. Over a three-day period historians, philosophers, and researchers who were actively engaged in various of the life sciences discussed specific examples of interdisciplinary research and tried to analyze what was needed for successful crossing of disciplinary boundaries. After the conference, each of the participants revised their original presentations, partly in light of the discussion at the conference. The papers in this volume are the fruits of that endeavor. (shrink)

This work discusses whether Kuhn's The Structure of Scientific Revolutions was revolutionary. Steve Fuller argues that Kuhn held a profoundly conservative view of science and how one ought to study its history.

Mitchell's formulation of the chemiosmotic theory of oxidative phosphorylation in 1961 lacked any experimental support for its three central postulates. The path by which Mitchell reached this theory is explored. A major factor was the role of Mitchell's philosophical system conceived in his student days at Cambridge. This system appears to have become a tacit influence on his work in the sense that Polanyi understood all knowledge to be generated by an interaction between tacit and explicit knowing. Early in his (...) life Mitchell had evolved a simple philosophy based on fluctoids, fluctids and statids which was developed in a thesis submitted for the Ph.D. at the University of Cambridge, England. This aspect of his work was rejected by the examiners and became a tacit element in his intellectual development. It is argued from his various publications that this philosophy can be traced as an underlying theme behind much of Mitchell's theoretical writing in the 50's leading, through his notion of vectorial metabolism, to the formulation and amplification of the chemiosmotic theory in the sixties. This philosophy formed the basis for Mitchell of his understanding of biological systems and gave him his unique approach to cell biology. (shrink)

In the 1950s–60s biochemists searched intensively for a series of high-energy molecules in the cell. Although we now believe that these molecules do not exist, biochemists claimed to have isolated or identified them on at least sixteen occasions. The episode parallels the familiar eighteenth-century case of phlogiston, in illustrating how error is not simply the loss of facts but, instead, must be actively constructed. In addition, the debates surrounding each case demonstrate how revolutionary-scale disagreement is sometimes resolved by differentiating or (...) partitioning empirical domains, rather than by replacement of one theory by another. (shrink)