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Evolution of Genetic Information without Error Replication

In Theoretical Information Studies. Singapur: pp. 295-319 (2020)

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  1. DNA Habitats and Their RNA Inhabitants.Guenther Witzany (ed.) - 2015
    Most molecular biological concepts derive from physical chemical assumptions about the genetic code that are basically more than 40 years old. Additionally, systems biology, another quantitative approach, investigates the sum of interrelations to obtain a more holistic picture of nucleotide sequence order. Recent empirical data on genetic code compositions and rearrangements by mobile genetic elements and non-coding RNAs, together with results of virus research and their role in evolution, does not really fit into these concepts and compel a re-examination. In (...)
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  • The Viral Origins of Telomeres and Telomerases and Their Important Role in Eukaryogenesis and Genome Maintenance.Guenther Witzany - 2008 - Biosemiotics 1 (2):191-206.
    Whereas telomeres protect terminal ends of linear chromosomes, telomerases identify natural chromosome ends, which differ from broken DNA and replicate telomeres. Although telomeres play a crucial role in the linear chromosome organization of eukaryotic cells, their molecular syntax most probably descended from an ancient retroviral competence. This indicates an early retroviral colonization of large double-stranded DNA viruses, which are putative ancestors of the eukaryotic nucleus. This contribution demonstrates an advantage of the biosemiotic approach towards our evolutionary understanding of telomeres, telomerases, (...)
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  • On the Origin of Telomeres: A Glimpse at the Pre‐Telomerase World.Jozef Nosek, Peter Kosa & Lubomir Tomaska - 2006 - Bioessays 28 (2):182-190.
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  • From Molecular Entities to Competent Agents: Viral Infection-Derived Consortia Act as Natural Genetic Engineers.Günther Witzany - 2012 - In Witzany (ed.), Viruses: Essential Agents of Life. Springer. pp. 407--419.
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  • Life is Physics and Chemistry and Communication.Gunther Witzany - 2015 - In Guenther Witzany (ed.), DNA Habitats and Their RNA Inhabitants. pp. 1-9.
    Manfred Eigen extended Erwin Schroedinger’s concept of “life is physics and chemistry” through the introduction of information theory and cybernetic systems theory into “life is physics and chemistry and information.” Based on this assumption, Eigen developed the concepts of quasispecies and hypercycles, which have been dominant in molecular biology and virology ever since. He insisted that the genetic code is not just used metaphorically: it represents a real natural language.However, the basics of scientific knowledge changed dramatically within the second half (...)
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  • The DNA Habitat and its RNA Inhabitants.Luis Villarreal & Guenther Witzany - 2013 - Genomics Insights 6:1-12.
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  • From the "'Logic of Molecular Syntax' to Molecular Pragmatism. Explanatory Deficits in Manfred Eigen's Concept of Language and Communication.Guenther Witzany - 1995 - Evolution and Cognition 2 (1):148-168.
    Manfred Eigen employs the terms language and communication to explain key recombination processes of DNA as well as to explain the self-organization of human language and communication: Life processes as well as language and communication processes are governed by the logic of a molecular syntax, which is the exact depiction of a principally formalizable reality. The author of the present contribution demonstrates that this view of Manfred Eigen’s cannot be sufficiently substantiated and that it must be supplemented by an approach (...)
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  • RNA as the Substrate for Epigenome-Environment Interactions.John S. Mattick - 2010 - Bioessays 32 (7):642-642.
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  • Soma to Germline Inheritance of Extrachromosomal Genetic Information Via a LINE-1 Reverse Transcriptase-Based Mechanism.Corrado Spadafora - 2016 - Bioessays 38 (8):726-733.
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  • Rethinking Quasispecies Theory: From Fittest Type to Cooperative Consortia.Luis Villarreal & Guenther Witzany - 2013 - World Journal of Biological Chemistry 4:79-90.
    Recent investigations surprisingly indicate that single RNA "stem-loops" operate solely by chemical laws that act without selective forces, and in contrast, self-ligated consortia of RNA stem-loops operate by biological selection. To understand consortial RNA selection, the concept of single quasi-species and its mutant spectra as drivers of RNA variation and evolution is rethought here. Instead, we evaluate the current RNA world scenario in which consortia of cooperating RNA stem-loops are the basic players. We thus redefine quasispecies as RNA quasispecies consortia (...)
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