An increasing number of European research projects return, or plan to return, individual genomic research results (IRR) to participants. While data access is a data subject’s right under the General Data Protection Regulation (GDPR), and many legal and ethical guidelines allow or require participants to receive personal data generated in research, the practice of returning results is not straightforward and raises several practical and ethical issues. Existing guidelines focusing on return of IRR are mostly project-specific, only discuss which results to (...) return, or were developed outside Europe. To address this gap, we analysed existing normative documents identified online using inductive content analysis. We used this analysis to develop a checklist of steps to assist European researchers considering whether to return IRR to participants. We then sought feedback on the checklist from an interdisciplinary panel of European experts (clinicians, clinical researchers, population-based researchers, biobank managers, ethicists, lawyers and policy makers) to refine the checklist. The checklist outlines seven major components researchers should consider when determining whether, and how, to return results to adult research participants: 1) Decide which results to return; 2) Develop a plan for return of results; 3) Obtain participant informed consent; 4) Collect and analyse data; 5) Confirm results; 6) Disclose research results; 7) Follow-up and monitor. Our checklist provides a clear outline of the steps European researchers can follow to develop ethical and sustainable result return pathways within their own research projects. Further legal analysis is required to ensure this checklist complies with relevant domestic laws. (shrink)

Karl Jaspers was the first major author who emphasized empathy as the proper method of the phenomenological approach to human psychopathology (“static understanding”). He divided mental symptoms into subjective and objective ones, stressing the crucial importance of the former. Subjective symptoms are mainly those expressing patients’ emotions as well as those experienced by them and verbally communicated during the diagnostic interview. Whereas the expressive symptoms can be grasped immediately by clinicians, the understanding of the experienced ones is mediated by patients’ (...) verbal communications as re-experienced or actualized in clinicians’ own consciousness. Thus, jaspersian empathic understanding is mediated by two distinct processes: the first is a direct and automatic one, whereas the second is an effortful process of “feeling oneself into other’s condition” or of “immersing oneself in other people’s self-description” which has to be learned by systematic and rigorous training. Both processes provide the core of what Jaspers called “static understanding”. This paper aims to show that Jaspers’ static understanding prefigures two main types of empathy emerging from contemporary scientific research in neuroscience and social psychology, namely “automatic emotional empathy” and “cognitive empathy”. (shrink)