In several counties, Vitex negundo have been claimed to have anti-inflammatory, analgesic, and antioxidant activities. It's frequently used in folk medicine for the treatment of various pain disorders. The methanol extract of Vitex negundo leaves was studied for its biological effects. To investigate different biological exertions of the methanol extract of Vitex negundo, the leaf extracts were obtained with pure methanol. In-vitro anti-oxidant activity was resolved using a DPPH radical scavenging assay. A clot lysis test was used to assess the (...) thrombolytic activity. Antiproliferative effects of DMSO Vitex negundo in cell lines acquired from human cervix adenocarcinoma (HeLa cells). Using the brine shrimp lethality bioassay method, the plant extracts were evaluated for cytotoxic action. LC50 values were determined through probit analysis of mortality percentages. In hole cross-test and open-field test, neuropharmacological activities of mice were assessed in mice. The findings revealed that Vitex negundo leaf extract possessed antioxidant effects, streptokinase exposed significant clot lysis and human cervix adenocarcinoma cells demonstrated mild cervical antiproliferative activity. Significant neuropharmacological action (antidepressant and anxiolytic) and cytotoxic action were shown by the methanol extract of Vitex negundo leaves. (shrink)

Schiff base ligands and their metal complexes are considered promising leads in the development of new drugs. Due to their outstanding ability to form chelate complexes, they readily interact with transition metals that possess vacant orbitals. Several benefits are associated with transition metal complexes due to their favorable biocompatibility and low toxicity in biological systems. This study seeks to investigate the synthesis of a novel Schiff base derived from two starting materials: p-anisaldehyde and cefuroxime. The p-anisalce-furoxime complex was synthesized by (...) coordinating it with metal ions of Cu2+ and Fe2+, resulting in the formation of new metal complexes. The antibacterial properties of these compounds were examined against gram-positive and gram-negative bacterial strains. These synthesized compounds were characterized using infrared spectroscopy (IR), nuclear magnetic resonance (NMR) spectroscopy 1H NMR, 13C NMR and UV spectral data, along with melting point measurement, chemical testing, thin-layer chromatography (TLC) analysis, colour testing, and solubility assessments, etc. Molecular docking analysis was concluded by docking SB ligands with PBP2x of Streptococcus pneumoniae, revealing the binding affinity of the SB ligand. The pharmacokinetic parameters of the SB ligand were studied using online web tools such as Swiss absorption, distribution, metabolism, and excretion (ADME), pkCSM, and admetSAR. Thus, the synthesized Schiff base ligand and its metal complexes exhibit significant antibacterial activity and promising pharmacokinetic properties, making them strong candidates for further development as antibacterial agents. (shrink)

The bruxism is a medical sleep syndrome it is the remedial span for crushing the tines and gritting the jowl. Human rarely chore their tines and jowl, slightly than crushing their teeth lacking it producing any signals. The symptoms of bruxism are arduousness in the jowl joint, breakable teeth, headache, earache and difficulty in open in mouth etc. The causes of bruxism are snooze sickness, pressure and nervousness. The REM is a rapid eye movement it's a stages of sleep. The (...) EEG signal are used in the measurement of neuron, the alpha, beta, gamma, theta and delta wave are used in the prognostic of bruxism syndrome. It's used in MATLAB coding by the six steps in prognostic in bruxism. Md Belal Bin Heyat | Faijan Akhtar | Shadab Azad "Comparative Analysis of Original Wave & Filtered Wave of EEG signal Used in the Prognostic of Bruxism medical Sleep syndrome" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-1 | Issue-1 , December 2016,. (shrink)